Nature Search

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity

SARS-CoV-2 variants of concern continue to emerge, reducing vaccine efficacy and limiting therapeutic options. Here, Chen and colleagues describe the identification and design of shark nanobodies with pansarbecovirus activity.

Wei-Hung Chen
Agnes Hajduczki
M. Gordon Joyce
ResearchOpen Access03 Feb 2023
Nature Communications

Volume: 14, P: 1-18
Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

An adjuvanted SARS-CoV-2 spike-ferritin nanoparticle vaccine can elicit antibodies with relatively broad sarbecovirus activity in non-human primates. Here, the authors isolate and structurally characterize several monoclonal antibodies providing insights into the targeted epitopes and broad reactivity.

Rajeshwer S. Sankhala
Kerri G. Lal
M. Gordon Joyce
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Membrane ruffling is a mechanosensor of extracellular fluid viscosity

Living cells change their behaviour in response to the viscosity of the medium surrounding them. An in vitro study shows that cells spread wider and move faster in a highly viscous medium, provided they have an actively ruffling lamellipodium.

Matthew Pittman
Ernest Iu
Yun Chen
Research25 Jul 2022
Nature Physics

Volume: 18, P: 1112-1121
Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na⁺/K⁺-ATPase

Ronald JY Chen
Tse-yu Chung
Jason TC Tzen
Research04 Jun 2010
Acta Pharmacologica Sinica

Volume: 31, P: 696-702
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

Krebs and colleagues identify multiple mAbs that recognize either the RBD or the NTD of SARS-CoV-2 spike protein that have potent cross-neutralizing activities against variants of concern. Combinatorial mAb cocktails have complementary effects on viral neutralization and Fc effector functions and can protect against SARS-CoV-2 escape mutants.

Vincent Dussupt
Rajeshwer S. Sankhala
Shelly J. Krebs
ResearchOpen Access29 Oct 2021
Nature Immunology

Volume: 22, P: 1503-1514
Operando time-resolved X-ray absorption spectroscopy reveals the chemical nature enabling highly selective CO₂ reduction

A systematic time-resolved study can provide key insights on selective carbon dioxide electro-reduction. Here, the authors report operando seconds-resolved X-ray absorption spectroscopy to uncover the chemical state evolution of working catalysts in a carbon dioxide electroreduction process.

Sheng-Chih Lin
Chun-Chih Chang
Hao Ming Chen
ResearchOpen Access14 Jul 2020
Nature Communications

Volume: 11, P: 1-12
Verifying the accuracy of self-reported smoking behavior in female volunteer soldiers

Wei-Hung Chan
Ching-Huang Lai
Yu-Lung Chiu
ResearchOpen Access01 Mar 2023
Scientific Reports

Volume: 13, P: 1-6
Investigating the rate of skeletal muscle atrophy in men and women in the intensive care unit: a prospective observational study

Ruo-Yan Wu
Wei-Hung Sung
Huan-Jui Yeh
ResearchOpen Access05 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
Leptin promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-27b in human chondrosarcoma cells

Wei-Hung Yang
An-Chen Chang
Chih-Hsin Tang
ResearchOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Structure of a Highly Active Cephalopod S-crystallin Mutant: New Molecular Evidence for Evolution from an Active Enzyme into Lens-Refractive Protein

Wei-Hung Tan
Shu-Chun Cheng
Chi-Yuan Chou
ResearchOpen Access08 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
Two-dimensional metal–organic framework for post-synthetic immobilization of graphene quantum dots for photoluminescent sensing

Graphene quantum dots have versatile properties, but their luminescence can be quenched when the dots aggregate. Here, the authors immobilize graphene quantum dots on 2D MOF sheets and demonstrate their photoluminescence in suspension and as a dry powder, and show their application in copper ion sensing.

You-Liang Chen
Darwin Kurniawan
Chung-Wei Kung
ResearchOpen Access11 May 2024
Communications Chemistry

Volume: 7, P: 1-7
Development and validation of a web-based prediction tool on minor physical anomalies for schizophrenia

Xin-Yu Wang
Jin-Jia Lin
Sheng-Hsiang Lin
ResearchOpen Access24 Feb 2022
Schizophrenia

Volume: 8, P: 1-7
SARS-CoV-2 spike-ferritin-nanoparticle adjuvanted with ALFQ induces long-lived plasma cells and cross-neutralizing antibodies

Shikha Shrivastava
Joshua M. Carmen
Mangala Rao
ResearchOpen Access18 Mar 2023
npj Vaccines

Volume: 8, P: 1-17
Association of retinopathy severity with cardiovascular and renal outcomes in patients with type 1 diabetes: a multi-state modeling analysis

Wei-Ming Wang
Huang-Tz Ou
Wei-Hung Lin
ResearchOpen Access09 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

Joshua M. Carmen
Shikha Shrivastava
Mangala Rao
ResearchOpen Access13 Dec 2021
npj Vaccines

Volume: 6, P: 1-18
Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis

Huey-En Tzeng
Syuan-Ling Lin
Chih-Hsin Tang
ResearchOpen Access23 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-12
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Kathryn McGuckin Wuertz
Erica K. Barkei
Kayvon Modjarrad
ResearchOpen Access28 Oct 2021
npj Vaccines

Volume: 6, P: 1-11
Active ingredients in Chinese medicines promoting blood circulation as Na⁺/K⁺-ATPase inhibitors

Ronald JY Chen
Tzyy-rong Jinn
Jason TC Tzen
Reviews04 Feb 2011
Acta Pharmacologica Sinica

Volume: 32, P: 141-151
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening

This study describes the characterization of a human endometrial epithelial cell line, hEM3. hEM3 is not transformed, can grow organoids, and does not harbor pathogenic mutations in genes involving DNA mismatch repair (MMR). hEM3 with ARID1A knockout has been generated for drug screening in an ARID1A-deficient and MMR-proficient context. In conclusion, hEM3 can be a model for studying endometrial pathogenesis.

Youngran Park
Jin-Gyoung Jung
Tian-Li Wang
Research10 Aug 2021
Laboratory Investigation

Volume: 101, P: 1505-1512

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