Marchetti et al. show that antibodies against Plasmalemma Vesicle Associated Protein (PV1) can be used to efficiently target drugs to lungs and kidneys. In a bleomycin induced lung fibrosis model, mice treated with anti-PV1 antibodies linked to an anti-fibrotic drug exhibited reduced collagen deposition and fibrosis progression compared to control antibodies.
- Gabriela M. Marchetti
- Timothy J. Burwell
- Ruchi Gupta
