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Tumor pericytes are located surrounding blood vessels, and can regulate tumor vascular structure. Here, the authors discover that a subpopulation of NKX2-3 high tumor pericytes modulates vasodilation and hemodynamics to promote metastasis.

The clinical outcomes of esophageal squamous cell carcinoma (ESCC) remain poor, and thus it remains critical to find prognostic molecular markers. Here, the authors identify prognostic ESCC subtypes based on bulk and single-cell RNA-seq combined with histology AI in samples from patients with more than four years of follow-up, and find markers associated with immune evasion.

An asymmetric self-assembled monolayer improves the efficiency of perovskite/silicon tandem solar cells compared with symmetric self-assembled monolayers, resulting in a certified power conversion efficiency of up to 34.58%.

Technical advancements have significantly improved early diagnosis of cervical cancer, but accurate diagnosis is still difficult due to various practical factors. Here, the authors develop an artificial intelligence assistive diagnostic solution to improve cervical liquid-based thin-layer cell smear diagnosis according to clinical TBS criteria in a large multicenter study.

Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive disease. Here, the authors identify recurrent somatic mutations of GNAQ in NKTCL, and model how this mutation contributes to NKTCL pathogenesis.

Many thrombolytic agents depend on plasminogen, leading to D-dimer accumulation. Here, Tang et al. report a plasminogen-independent thrombolytic enzyme that degrades blood clots and D-dimer without plasminogen.

This Review examines membrane and electrochemical technologies for direct lithium extraction, focusing on separation mechanisms, performance trade-offs and the influence of brine composition. It offers a blueprint for treatment train integration and highlights key opportunities and challenges to advance direct lithium extraction toward practical and scalable industrial adoption.

Grain boundaries in graphene degrade its properties, and large single-crystal graphene is desirable for electronic applications of graphene. Gaoet al. develop a method to produce millimetre-sized hexagonal single-crystal graphene grains, and films composed of the grains, on platinum by chemical vapour deposition.

Determining glioma types directly from whole-slide images (WSIs) would be of great diagnostic utility. Here, the authors develop a deep learning model to identify diffuse glioma types from WSIs according to the 2021 WHO classification across multiple cohorts and with interpretable features.

Ultraclean and damage-free transfer of graphene over large areas is crucial for the future development of flexible electronics and optoelectronics. Using a rosin-assisted method, the authors transfer graphene with an ultraclean surface and uniform small sheet resistance—a 4-inch monolithic organic light-emitting diode is demonstrated.

In this study, Wang et al. show that the glycolytic metabolite phosphoenolpyruvate, produced by enolase 2, contributes to colorectal cancer malignancy and resistance to antiangiogenic therapy by inhibiting endogenous histone deacetylase 1 and favouring β-catenin signalling.

The water electrolytic oxidation of graphite is a low-cost sustainable synthesis method for the large-scale production of graphene oxide (GO), but it is usually limited by non-uniform oxidation. Here, the authors report a liquid membrane electrolysis method enabling the high-yield synthesis of uniform monolayer GO at industrial scales.

Semiconducting materials are potential SERS substrates as alternatives to noble metals, but often suffer from poor stabilities and sensitivities. Here, the authors use molybdenum dioxide as a SERS material, showing high enhancement factors and stability to oxidation even at high temperatures.

Ambient-stable solution-processed conductive materials with a low work function are essential to facilitate electron injection. Here, the authors design and synthesise polymer electrolyte with work function down to 2.2 eV for applications in high-performance light-emitting diodes and solar cells.

2D semiconductors with high thermal conductivity are essential for next-generation electronics. Here, the authors report a high thermal conductivity of ~173 W·m^–1 ·K^–1 for monolayer MoSi₂N₄, surpassing the known 2D semiconductors and silicon.

Investigation of the electronic structure in few-layer phosphorene reveals optical transitions relevant for technologically important electronic and optoelectronic applications.

High performance proton conductor is highly desired for energy application. Here authors report an increase in the number of active protons in solid acid at the monolayer limit, enabling membranes with proton conductivity 5 times higher than that of Nafion.

Direct seawater electrolysis is promising for sustainable hydrogen production but suffers severe side reactions and corrosion. Here, the authors report a corrosion-resistant electrocatalyst with in situ-formed chloride-ion-repelling cation layer for efficient and long-lasting seawater oxidation.

The authors developed a deep learning model predictive of 1p/19q status from preoperative imaging in 555 lower-grade gliomas (LGG), and achieved an area under the curve (AUC) of 0.983 in the testing dataset. They reveal that developing deep learning imaging signatures could be a noninvasive tool for predicting molecular markers in LGG.

The 2D carbon allotrope graphdiyne possesses a direct band gap, high charge carrier mobility, and uniformly distributed pores. Here, the authors report the surfactant-free growth of graphdiyne hollow microspheres and investigate the origin of their SERS activity.

The discovery of a new two-dimensional van der Waals layered MoSi₂N₄ material inspires many attentions. Here, the authors report intercalation strategies to explore a much wider range of MA₂Z₄ family and predict amount of materials accessible to experimental verifications with emergent topological, magnetic or Ising superconductivity properties.

This study presents constraints on seismic anisotropy properties in western-central Tibet, revealing pronounced north-directed basal shearing beneath the rifts in the southern plateau that sheds light on the cause of syncontractional extension there.

WS₂ is a promising material for application in next-generation electronics, yet current methods of fabrication can only yield micrometre-sized domains. Here, via ambient-pressure CVD, the authors report the growth of high-quality, uniform monolayer WS₂single crystals of the order of millimetres.

Water electrolysis is a promising hydrogen production technique but is restricted from large-scale application due to poor performance and high cost. Here, the authors report a mechanically stable monolith electrocatalyst that achieves superior hydrogen evolution at large current densities.

Here, the authors exploit a photo-induced barrier-lowering mechanism in MoS₂/ α-MoO_3-x heterojunctions to realize two-dimensional phototransistors with enhanced performance and fast response at low bias voltage.

Graphene oxide membranes show great potential for water filtering, but improving their performance and stability remains difficult. Here, the authors use theanine amino acid and tannic acid to reduce and cross-link graphene oxide membranes with remarkably high permeability and stability in aqueous solution.

Molybdenum nitride is promising for catalysis, energy storage and Raman scattering, but it is synthesized under harsh conditions. Here the authors synthesize highly crystalline molybdenum nitride nanosheets using a relatively mild, non-aqueous solvothermal approach that can be extended to other nitrides.

Nano-crystallization is essential to tune different properties of materials. Here, the authors report a synthesis strategy that involves quenching of a hot metal foil for few seconds in liquid carbon source to form graphene films of 3.6 nm grain size, showing mechanical strength of 101 GPa and semiconducting behaviour.

METTL3, the enzyme responsible for m⁶A modification, influences translation by interacting with eIF3h to mediate looping between the regions near the stop codon and 5′ cap of mRNA.

This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.