G-quadruplex (G4) structures are found in eukaryotic cell replication origins, but their role remains unclear. Here, the authors show that G4 in the cytomegalovirus replication origin is critical in recruiting viral replication factors and that G4-binding ligands inhibit viral factors’ G4 binding.
- Daegyu Park
- Woo-Chang Chung
- Jin-Hyun Ahn