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Zhang, Mille-Fragoso and colleagues developed a synthetic receptor platform named LIDAR (Ligand-Induced Dimerization-Activating RNA editing), which enables ligand-responsive gene regulation without the need of DNA promoters and is, thus, compatible with mRNA delivery.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

The two dimensional magnetoplasmon edge state has been observed for a long time, but its nature is yet to be uncovered. Here, Jin et al. report that such a state is actually topological protected, analogous to the chiral Majorana edge state in a p-wave topological superconductor.

Metabolic liver disease is highly prevalent in subjects with obesity and involves inflammation, insulin resistance, and fibrosis, leading to cirrhosis. Here, the authors show the IFNγ-IL12 axis in regulating intercellular crosstalk in the liver and playing a major role in the pathogenesis of metabolic liver disease.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Disruption of different components of molecular circadian clocks has varying effects on health and lifespan of model organisms. Here the authors show that loss of period extends life in drosophila melanogaster.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Many X-ray imaging techniques require transmission geometries, which place severe restrictions on the samples being imaged. Here, a reflection geometry lensless X-ray imaging method is demonstrated. This technique may allow single-shot imaging of surfaces and films such as organic photovoltaic materials and field-effect transistor devices, or Bragg planes in a single crystal.

The first operation of the European X-ray free-electron laser facility accelerator based on superconducting technology is reported. The maximum electron energy is 17.5 GeV. A laser average power of 6 W is achieved at a photon energy of 9.3 keV.

The STAR collaboration reports a measurement of the mass difference and binding energy of the hypertriton and its antiparticle. This work constrains the hyperon–nucleon interaction and allows us to test the CPT theorem in a nucleus with strangeness.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

It is common to engineer membrane proteins for cryo-EM analysis. Here, the authors report a cryo-EM structure of an engineered, functional VMAT2 with a non-canonical fold. Caution is advised when interpreting engineered membrane protein structures.

The dynamics of liquid water is rich due to its complex, highly disordered hydrogen-bond network, which hasn’t been fully understood. Perakis et al. measure water dynamics at sub-100 fs and show that it cannot be described by simple thermal motion due to the build-up of tetrahedral structures upon supercooling.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

The elimination of specific contaminants from high concentrations of competitors poses a significant challenge. Here the authors find that modifying the local environment of the direct contact site alters the interaction of a pyridinium-based anion nanotrap with pertechnetate.

The authors present a soft metalens (SML) with tungsten-gel composite for ultra-broadband transcranial focus, significantly enhancing intracranial sound pressure and spatial resolution. This breakthrough advances underwater sonar, medical ultrasound imaging, and non-invasive detection for energy transmission.

The collective-flow-assisted nuclear shape-imaging method images the nuclear global shape by colliding them at ultrarelativistic speeds and analysing the collective response of outgoing debris.

The authors here report a binder-free electrode based on tin nanoarrays deposited on copper substrate. It is found that the locally formed electrochemically inactive tin-copper alloys work as a glue that bridges tin and copper to survive harsh cycling conditions in sodium ion batteries.

Cancers dependent on hedgehog pathway signaling are susceptible to the BET bromodomain inhibitor JQ1.

Here, the authors report photon-energy-dependent terahertz emission and ultrafast photocurrents from the Weyl semimetal, TaAs. The polarization control of the emission is achieved by excitation of the photocurrents whose direction and magnitude depend on the polarization of the femtosecond optical pulses.

Here the authors present a wet-interfacial Joule heating approach for synthesizing nanomaterials in a sub-second, programmable, and energy/reactant-saving manner, based on the synergy between Joule-heating-based high temperature and evaporation-caused concentration.

Lithium cobalt oxides are used as a cathode material in batteries for mobile devices, but their high theoretical capacity has not yet been realized. Here, the authors present a doping method to enhance diffusion of Li ions as well as to stabilize structures during cycling, leading to impressive electrochemical performance.

A repeated on–off high-temperature shockwave is shown to be a generalizable way of efficiently synthesizing and stabilizing single atoms at high temperatures.

A comparison of electron scattering from the mirror nuclei hydrogen-3 and helium-3 reveals that proton–proton pairs have a much larger contribution to short-range correlations in helium-3 than in heavier nuclei, implying an unexpected nuclear structure.

Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.

The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.

The nature of correlated insulator states commonly observed in moiré superlattices are still under investigation. Here, the authors use pump-probe spectroscopy to study the dynamics of correlated insulator states in a WSe₂/WS₂ moiré heterostructure at two different fillings, elucidating distinct time-domain signatures associated with these states.

Sodium-sulfur batteries show potential as attractive alternatives to Li-ion batteries due to their high energy density but practicality is hampered by sodium polysulfide issues. Here, the authors introduce an intercalation-type catalyst MoTe2 to improve the redox kinetics in Na-S batteries.

Nano-bio interfaces enable communication between synthetic materials and biological systems at the nanoscale, with their functionality shaped by material properties, surface chemistry and topography. This Review discusses the key considerations and methods for engineering nano-bio interfaces for bioelectrical signal detection and biochemical signal transduction.

Contact parameterises two-body correlations at short distances in dilute systems like ultracold atomic gases. Using a fundamental thermodynamic relation, Chen et al.study the contact near a continuous classical or quantum phase transition and find that it displays a number of critical behaviours.

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G₁₁ and G_o, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.

SET domain–containing 2 (SETD2) is reported as an immunosuppressor in clear cell renal cell carcinoma (ccRCC). Here the authors show that SETD2 loss enhances de novo sphingomyelin biosynthesis during the transition from polycystic kidney disease to ccRCC.

Zinc batteries are receiving growing attention due to their sustainability merits not shared by lithium-ion technologies. Here the aqueous electrolyte design features unique solvation structures that render Zn–air pouch cell excellent cycling stability in a wide temperature range from −60 to 80 °C.

An antimatter hypernucleus formed by an anti-lambda hadron, an antiproton and two antineutrons was observed through its two-body decay after production in ultrarelativistic heavy-ion collisions.

China’s dramatic demographic shift toward population aging raises challenges at the individual, familial and societal levels. Fang et al. review these challenges and emerging policies designed to promote healthy longevity in China.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

Kagome superconductors host a panoply of condensed matter phenomena, some of which are mediated by band topology. Here, authors use ARPES and DFT to identify type-II and type-III Dirac nodal lines, flat bands and topological surface states in the kagome metal CsTi₃Bi₅.

Measurement of low-affinity protein–protein interactions is challenging; surface plasmon resonance requires high concentrations of reagents. Here the authors combine magneto-nanosensors with microfluidic chips and protein-conjugated magnetic nanoparticles to discover a low-affinity interaction between T-cell inhibitory receptors PD-L1 and PD-L2.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

A terahertz-driven photogun with field gradients of 3 GV m⁻¹ is demonstrated by using a few microjoules of single-cycle terahertz radiation. The emitted electrons are accelerated up to 14 keV and can be focused down to 90 μm. The electron bunch is further compressed to 167 fs.

Genome-wide association analysis of gout and urate identifies 148 new loci, implicating biological pathways and prioritizing candidate genes involved in inflammatory processes.

Antibody and antibody-avidity assays relying on near-infrared-fluorescence amplification by nanostructured plasmonic gold substrates accurately quantify antibodies to SARS-CoV-2 and to common viruses in human serum and saliva.

A low cost MRI scanner may have the potential to meet clinical needs at point of care or in low and middle income countries. Here the authors describe a low cost 0.055 Tesla MRI scanner that operates using a standard AC power outlet, and demonstrate its preliminary feasibility in diagnosing brain tumor and stroke.

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype with limited effective therapeutic options. Here, the authors identify the RNA-binding protein ELAVL3 as a driver of differentiation into NEPC via a positive feedback loop with MYCN and demonstrate the use of the repurposed drug pyrvinium pamoate to target this axis using preclinical models of NEPC.

An experimental investigation of the dynamics of the spin ½ Floquet XXZ model finds bound states as predicted, and also robustness to noise and non-integrability when theoretical descriptions start to fail.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

Highly stretchable organic electrochemical transistors with stable charge transport under severe tensional strains are demonstrated using a honeycomb semiconducting polymer morphology, thereby enabling controllable signal output for diverse stretchable bioelectronic applications.