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Layered Ni-rich oxide cathodes are susceptible to challenges with surface reconstruction and strain propagation, limiting their cyclability. The authors propose a solution involving oriented attachment-driven reactions, utilizing Wadsley–Roth nanocrystals and layered oxide to induce an epitaxial entropy-assisted coating, effectively addressing these issues.

Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants inZMIZ1 and near NGFconferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Symmetry plays a crucial role in defining the band topology. Here, the authors experimentally demonstrate that spacetime inversion symmetry can lead to Stiefel-Whitney topological charges and protect hinge states in an acoustic nodal-line semimetal.

Ryugu is more primitive than carbonaceous chondrites, according to elevated noble gas concentrations. Elevated Xe and its isotopic composition further provide constraints on fractionation of the solar composition to form the early planetary components.

This work presents a computational framework, COMMOT, to spatially infer cell–cell communication from transcriptomics data based on a variant of optimal transport (OT).

A 10-Earth-mass planet is detected in the habitable zone of the solar-type star Kepler-725 using the transit timing variation technique. This study proposes a complementary pathway to probe low-mass exoplanets (including Earth-like planets) in the habitable zones of Sun-like stars.

Designing electrode architectures for Li-ion batteries that can be reversibly accessible for ion storage can be challenging. Using operando techniques the mechanistic origin of lithiation-induced phase transformations in a V₂O₅ model cathode is now clarified.

In situ synchrotron X-ray tools are used to perform microstrain screening during solid-state synthesis of battery materials, leading to fewer structural defects and improved performance.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Relating the degree of network crosslinking as a descriptor to the desalination performance of crosslinked polymer membranes remains challenging. Here, the authors introduce a parameter based on distinct amide bonds per unit mass of polyamide, to unravel the relationship between the crosslinked networks of polyamide membranes and their desalination performance.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Recently, superconductivity near 80 K was observed in La3Ni2O7 under high pressure, but the mechanism is debated. Here the authors report angle-resolved photoemission spectroscopy measurements under ambient pressure, revealing flat bands with strong electronic correlations that could be linked to superconductivity.

Analysis of interactions between the wheels of the Zhurong rover and the terrain along the rover’s traverse reveals soils with high bearing strength and cohesion.

Whistler-mode chorus waves have been observed in the tail region of the terrestrial magnetosphere, where the magnetic field is not dipolar so that chorus waves were not expected, and their generation mechanisms have been tested with state-of-the-art observations.

It remains a challenge to find the structure and the distribution of the constituents of nucleons. Here the authors use a scattering method to get information about the gluons and quarks inside a proton and separate the contribution of Bethe-Heitler from the deeply virtual Compton scattering process.

Solvent-mediated interaction networks control a wide range of protein functions, but their design has been neglected owing to a lack of accurate computational tools. Now it is shown that allosteric signalling membrane proteins can be engineered through such networks, revealing a broader space of designable protein interactions and functions.

Non-Hermiticity is usually considered detrimental to quasiparticle physics. Here, the authors show that such an assumption of Hermiticity can be lifted in the context of a lattice model containing two non-Hermitian Dirac cones, with one hosting amplifying Dirac quasiparticles and the other hosting decaying ones.

SEAM is a platform for the analysis of high-resolution secondary ion mass spectrometry imaging that allows spatially resolved nuclear metabolomic profiling at the single-cell level.

Origami-based soft robotic manipulators offer compactness, cost-effectiveness, and scalability, but challenges related to stiffness, precision, and dexterity remain. To address these issues, the authors introduce the Micro-X4, a 4-degree-of-freedom origami micromanipulator that is capable of achieving three-dimensional translational motion, along with rotation around the central axis of the moving platform.

How a Mott insulating state evolves into a conducting or superconducting state is a central issue in doping a Mott insulator and important to understand the physics in high temperature cuprate superconductors. Here, the authors visualize the electronic structure evolution of a Mott insulator within the full Mott gap region and address the fundamental issues.

A multi-omic atlas of breast cancers, integrating single-cell RNA sequencing, spatial transcriptomics and immunophenotyping, identifies nine ecotypes associated with cellular heterogeneity and prognosis.

In this work, the authors demonstrate that LLPS of the quaternary USH2 protein complex initiates the formation of stereociliary ankle link condensates, providing insights into the pathogenesis of deafness.

Low effective doping of boron limits the performance of solar cells based on hydrogenated amorphous silicon. Liu et al. show that light induces the diffusion of hydrogen atoms, which activates boron doping, enabling a power conversion efficiency of over 25%.

The efficacy of cancer immunotherapy relies on the sufficient functional immune cells recruited. Here this group designs an abemaciclib-loaded supramolecular peptide hydrogel achieving sustained release after intratumoral injection to effectively induce cancer cell death and increase IL-2 secretion, thereby exerting immunotherapy for triple-negative breast cancer.

A low cost MRI scanner may have the potential to meet clinical needs at point of care or in low and middle income countries. Here the authors describe a low cost 0.055 Tesla MRI scanner that operates using a standard AC power outlet, and demonstrate its preliminary feasibility in diagnosing brain tumor and stroke.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G₁₁ and G_o, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Layered oxide heterostructures are widely studied because of the new quantum states that can arise at the interface between the oxide materials used. Here, the authors are able to link the rotation of crystallographic oxygen octahedra at the interface to a modified ferromagnetic state in such heterostructures.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Single-atom metal catalysts offer maximized material efficiency, but there is large room to improve the intrinsic activity per metal atom for many reactions. Here, the authors demonstrate that the solution for CO oxidation is to tackle the issue of lacking neighboring Pt atoms in the single-atom Pt1/CeO2 system.

Hybrid perovskites are highly promising for photovoltaic applications, but they are prone to decomposition. Here, the authors probe the stability of CH₃NH₃PbI₃ films in a transmission electron microscope, defining the threshold conditions to avoid damage under the electron beam, and describing a decomposition pathway.

Oxygen redox instability at high voltages hinders the application of high-energy battery cathodes. Here the authors report that elimination of domain boundaries in single-crystal cathodes improves the redox stability and consequently the electrochemical performance in extended high-voltage cycling.

Recently, clathrate superhydride superconductors have garnered significant attention. Here the authors measure the electron-phonon coupling strength and superconducting gap of an ultrahigh pressure superconductor LaH_10±δ by ultrafast spectroscopy, revealing a strong coupling nature of the superconductivity.

A sequencing chemistry that separates nucleotide identification from nucleotide incorporation achieves high accuracy.

Valley dependent spin polarization called spin-valley locking appears in absence of magnetism but it is limited to rare examples of transition metal dichalcogenides. Here, the authors report evidence of spin-valley locking and stacked quantum Hall effect in a bulk Dirac semimetal BaMnSb₂.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

Quantum phase transition occurs in many-body systems with abrupt changes in the ground state around zero temperature. Here the authors report signatures of quantum phase transition in single trapped ion that can be described using quantum Rabi model.

Sustainable management of soil organic carbon (SOC) in farmland is critical for mitigating climate change and improving soil health. Degradable film mulching is a promising alternative to plastic film mulching, sequestering SOC and reducing C loss in dryland agroecosystems under climate change.

Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

Using remote sensing, this study establishes the nitrogen budget for 5,768 lakes. Results show that reducing watershed nitrogen input improves water quality nonlinearly, emphasizing targeted watershed management to meet the SDG of global clean water.

Tao et al. reported a series of cryo-EM structures of α-synuclein fibrils in complex with amyloid dyes and imaging tracers, and identified druggable pockets in the fibrils of multiple system atrophy.

Layered oxide cathode materials for sodium-ion batteries often experience irreversible phase transitions and structural instability. Now researchers have developed a P2-type oxide containing earth-abundant elements, featuring an intergrowth phase structure that enables long-cycle, high-energy sodium-ion batteries.

Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis.