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Showing 101–150 of 773 results
Advanced filters: Author: X. Y. Wei Clear advanced filters
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Ring currents have been observed in the magnetospheres of Earth, Jupiter, and Saturn. Here, the authors show observational evidence of Mercury’s ring current that is bifurcated because of the dayside off-equatorial magnetic minima.

    • J.-T. Zhao
    • Q.-G. Zong
    • Y. Wei
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10
  • Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

    • Vinayak Bhandari
    • Constance H. Li
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • While diamond is the strongest natural material, it fails to reach its theoretical elasticity limits and is brittle. Here, the authors show that thin <100>-orientated diamond nanoneedles can reach diamond’s theoretical strength and elasticity limits in tension.

    • Anmin Nie
    • Yeqiang Bu
    • Wei Yang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7
  • Single-atom catalysts demonstrate enhanced catalytic properties, but most systems only explore combinations of a few different metals. Here, a library of 37 different elements is investigated, and it is shown that loading 12 metallic atoms in one system presents improved electrochemical activity.

    • Lili Han
    • Hao Cheng
    • Huolin L. Xin
    Research
    Nature Materials
    Volume: 21, P: 681-688
  • Recent studies reported evidence of a new phase in the kagome metal CsV3Sb5 between the charge density wave and superconducting transitions. Here the authors reveal symmetry properties of this phase in CsV3Sb5 thin flakes probed by in-plane magnetotransport, suggesting a 3D orbital current order.

    • Xinjian Wei
    • Congkuan Tian
    • Jian-Hao Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8
  • A low-potential dual-side hydrogen production system is more efficient than water splitting but suffers from stability issues. Here, the authors report a self-reactivating PdCu catalyst that operates stably for 120 h, offering an alternative solution for energy-efficient hydrogen production.

    • Ming Yang
    • Yimin Jiang
    • Yuqin Zou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • The interaction between antiferromagnetic magnons and electrons sits at the heart of many strongly correlated systems, however, investigation has been hampered by a lack of clear-cut examples. Here, Yu et al directly observe a kink in the dispersion, a result of renormalization due to the electron-antiferromagnetic magnon interaction.

    • T. L. Yu
    • M. Xu
    • D. L. Feng
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8
  • A miniaturized and low-power-consumption system is designed to allow the accurate sensing and wireless transmission of internal temperature and strain signals inside lithium-ion batteries with negligible influence on their performance, improving their safety.

    • Jinbao Fan
    • Chenchen Liu
    • Daining Fang
    Research
    Nature
    Volume: 641, P: 639-645
  • Zhang, Mille-Fragoso and colleagues developed a synthetic receptor platform named LIDAR (Ligand-Induced Dimerization-Activating RNA editing), which enables ligand-responsive gene regulation without the need of DNA promoters and is, thus, compatible with mRNA delivery.

    • Xiaowei Zhang
    • Luis S. Mille-Fragoso
    • Xiaojing J. Gao
    Research
    Nature Chemical Biology
    Volume: 21, P: 1250-1261
  • Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both brain region and transcriptomic profile.

    • Hanchuan Peng
    • Peng Xie
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 598, P: 174-181
  • A South China Sea expedition in 2021 identified a 3.5-km-deep site close to the Equator for a next-generation neutrino telescope: TRIDENT. A large array of advanced detectors will be arrayed on the seabed to probe fundamental physics and explore the extreme Universe.

    • Z. P. Ye
    • F. Hu
    • G. J. Zhuang
    ResearchOpen Access
    Nature Astronomy
    Volume: 7, P: 1497-1505
  • Mapping of the mouse cerebellar cortex using 3D reconstruction from electron microscopy, as well as numerical simulation of neuronal activity, shows non-random redundancy of connectivity that may favour resilient learning over encoding capacity.

    • Tri M. Nguyen
    • Logan A. Thomas
    • Wei-Chung Allen Lee
    Research
    Nature
    Volume: 613, P: 543-549
  • The role Tibetan Plateau uplift played in Asian inland aridification remains unclear due to a paucity of accurately dated records. Here, the authors present a continuous aeolian sequence for the period >51–39 Ma, analysis of which indicates that aridification was driven by global climatic forcing rather than uplift.

    • J. X. Li
    • L. P. Yue
    • Q. S. Liu
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

    • M. Ablikim
    • M. N. Achasov
    • J. H. Zou
    ResearchOpen Access
    Nature
    Volume: 606, P: 64-69
  • Developing planar phononic circuits analogous to photonic circuits are of interest to provide scalable advantages and complex manipulation of phonons. Here, the authors realize a phononic integrated circuit with a Gallium Nitride-on-sapphire platform, which provides strong confinement and control of phonons.

    • Wei Fu
    • Zhen Shen
    • Hong X. Tang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7
  • Results from the first experimental campaign of the Wendelstein 7-X stellarator demonstrate that its magnetic-field design grants good control of parasitic plasma currents, leading to long energy confinement times.

    • A. Dinklage
    • C. D. Beidler
    • M. Zuin
    Research
    Nature Physics
    Volume: 14, P: 855-860
  • Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.

    • Xue Wang
    • Haibo Xu
    • Helen He Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.

    • Jin-Yu Yang
    • Xiang-Yu Deng
    • Song Gao
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

    • Tuomas O. Kilpeläinen
    • Amy R. Bentley
    • Ruth J. F. Loos
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Multi-modal analysis is used to generate a 3D atlas of the upper limb area of the mouse primary motor cortex, providing a framework for future studies of motor control circuitry.

    • Rodrigo Muñoz-Castañeda
    • Brian Zingg
    • Hong-Wei Dong
    ResearchOpen Access
    Nature
    Volume: 598, P: 159-166
  • The process of protein crystallization is poorly understood and difficult to program through the primary sequence. Here the authors develop a computational approach to designing three-dimensional protein crystals with prespecified lattice architectures with high accuracy.

    • Zhe Li
    • Shunzhi Wang
    • David Baker
    Research
    Nature Materials
    Volume: 22, P: 1556-1563
  • Metal- and N-coordinated carbon materials are promising electrocatalysts, but improved activity and stability are desirable for fuel cell applications. Chang et al. address this by introducing F atoms into Pd/N–C catalysts, modifying the environment around the Pd and enhancing performance for ethanol oxidation and oxygen reduction.

    • Jinfa Chang
    • Guanzhi Wang
    • Yang Yang
    Research
    Nature Energy
    Volume: 6, P: 1144-1153
  • Well-defined single-atom alloy (SAA) nanocrystals possess isolated atom centres and tunable electronic properties but are challenging to synthesize. Here, a direct solution-phase synthesis of Cu/CuAu core/shell nanocubes with tunable SAA layers is reported. The Cu/CuAu nanomaterial is highly active for the electrocatalytic conversion of nitrate into ammonia.

    • Qiang Gao
    • Bingqing Yao
    • Huiyuan Zhu
    Research
    Nature Synthesis
    Volume: 2, P: 624-634
  • Hydrogen-doping driven metal to ferroelectric phase transition in a complex oxide NdNiO3 is demonstrated. Transient negative differential capacitance and implementation of polarization decay into neural network for learning are then presented.

    • Yifan Yuan
    • Michele Kotiuga
    • Shriram Ramanathan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11
  • Effectively delivering medications to the renal tubule to delay or halt chronic kidney disease progression remains a significant unmet clinical challenge. Here, authors introduce an innovative strategy for renal tubule targeting using biomimetic high-density lipoprotein (bHDL) nanoparticles.

    • Shanshan He
    • Xiaoyang Li
    • Ling Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Edge-localized plasma modes in a tokamak can damage its innermost wall. Simulations now show that fast ions can modify the spatio-temporal structure of these modes. These effects need to be considered in the optimization of control techniques.

    • J. Dominguez-Palacios
    • S. Futatani
    • M. Zuin
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 43-51
  • Understanding and exploiting the redox properties of uranium is of great importance but stabilizing both low and high valent uranium ions in a preserved ligand environment remains challenging. Here, the authors report the synthesis and characterisation of a series of uranium(II–VI) complexes supported by a tripodal tris(amido)arene ligand.

    • Chong Deng
    • Jiefeng Liang
    • Wenliang Huang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-7
  • STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

    • Xihao Li
    • Zilin Li
    • Xihong Lin
    Research
    Nature Genetics
    Volume: 52, P: 969-983
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330
  • CO2 electroreduction is a promising process for the production of high-value chemicals, but achieving high selectivities for specific products is challenging. Now, a Faradaic efficiency of 87% for acetate is achieved on a Cu/CuOx catalyst under 58 atm CO2(g), where high and low concentrations of dissolved CO2(aq) and proton donor HCO3 are shown to promote acetate formation, respectively.

    • Jiachen Li
    • Yun Kuang
    • Hongjie Dai
    Research
    Nature Catalysis
    Volume: 6, P: 1151-1163
  • Chronic wounds significantly diminish quality of life. Here, the authors developed a wearable LED device and sprayable fibrin gel for safe home use. The LED device and fibrin gel effectively eradicated microbes and improved wound healing, as validated in infected diabetic wounds in mice and minipigs

    • Ming Li
    • Chenxi Wang
    • Min Lu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Here, a draft sequence of the giant panda genome is assembled using next-generation sequencing technology alone. Genome analysis reveals a low divergence rate in comparison with dog and human genomes and insights into panda-specific traits; for example, the giant panda's bamboo diet may be more dependent on its gut microbiome than its own genetic composition.

    • Ruiqiang Li
    • Wei Fan
    • Jun Wang
    ResearchOpen Access
    Nature
    Volume: 463, P: 311-317
  • An anomalous exothermal calorimetric peak far below crystallization temperatures in prototypical Pd-Ni-P glasses has been recognized for four decades. Here authors use neutron and high-energy X-ray diffraction to find evidence for a polyamorphous phase transition where medium-range order undergoes large changes while short-range order changes little.

    • S. Lan
    • Y. Ren
    • X. -L. Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8
  • Prostate cancers (PCa) are characterized by an immunosuppressive tumor microenvironment. Here the authors identify a subset of iron-loaded cancer-associated fibroblasts secreting myeloid cell-associated proteins and driving immunosuppression in PCa.

    • Kai Zhang
    • Kaiyuan Liu
    • Helen He Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19