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A lanthanide–carbon triple bond stabilized within a fullerene cage

The synthesis and isolation of compounds featuring lanthanide–carbon triple bonds remain challenging. Now a cluster featuring a cerium–carbon triple bond has been stabilized inside a C₈₀ fullerene cage. The solid-state structure of the compound reveals a cerium–carbon bond distance of 1.969(7) Å.

Hongjie Jiang
Jing Zhao
Ning Chen
Research19 Jun 2025
Nature Chemistry

Volume: 17, P: 1364-1370
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

Xiao-kun Zhang
Birgit Hoffmann
Magnus Pfahl
Research30 Jan 1992
Nature

Volume: 355, P: 441-446
In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor

Shao-hong Li
Shao-xi Cai
Xiao-kun Li
Research01 Jun 2006
Acta Pharmacologica Sinica

Volume: 27, P: 754-759
Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood

Xiao-kun Zeng
You-fei Guan
Xian Wang
Research01 Jan 2005
Acta Pharmacologica Sinica

Volume: 26, P: 85-91
Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in intestinal epithelial cells, which can be suppressed by ligand K-80003.

Xiaohong Ye
Hua Wu
Xiao-kun Zhang
ResearchOpen Access01 Apr 2019
Nature Communications

Volume: 10, P: 1-15
Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post-translational levels which is relevant to colon cancer stemness, metastasis and resistance to oxaliplatin.

Boning Niu
Jie Liu
Hu Zhou
ResearchOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-17
Development and validation of a novel nomogram to predict worsening of gastroesophageal reflux symptoms after laparoscopic sleeve gastrectomy using Lasso-logistic regression

Lei Jin
Xiao-Kun Huang
Yao-Juan Wu
ResearchOpen Access25 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways

Dong-xue Wang
Wen-ting Huang
Li Lin
ResearchOpen Access28 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1834-1851
¹²⁴I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies

Xiao-kun Ma
Te-li Liu
Zhi Yang
Research25 Sept 2023
Acta Pharmacologica Sinica

Volume: 45, P: 436-448
Induction of retinoic acid receptor-β suppresses cyclooxygenase-2 expression in esophageal cancer cells

Ming Li
Shumei Song
Xiao-Chun Xu
Research24 Jan 2002
Oncogene

Volume: 21, P: 411-418
FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

De-pu Zhou
Lian-cheng Deng
Jin-San Zhang
ResearchOpen Access24 May 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2004-2018
circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis

Shuo Tan
Ye Kang
Xuan Zhu
ResearchOpen Access10 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-15
bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway

Zhou-Guang Wang
Yue Wang
Jian Xiao
ResearchOpen Access19 Mar 2015
Scientific Reports

Volume: 5, P: 1-12
Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

Rui Li
Duo-hui Li
Jian Xiao
ReviewsOpen Access02 Mar 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1289-1300
Targeting NAD+: is it a common strategy to delay heart aging?

Yang Yuan
Bing Liang
Dong-Ming Xing
ReviewsOpen Access26 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-14

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A lanthanide–carbon triple bond stabilized within a fullerene cage

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic fibroblast growth factor

Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Development and validation of a novel nomogram to predict worsening of gastroesophageal reflux symptoms after laparoscopic sleeve gastrectomy using Lasso-logistic regression

FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways

¹²⁴I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies

Induction of retinoic acid receptor-β suppresses cyclooxygenase-2 expression in esophageal cancer cells

FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis

bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration

Targeting NAD+: is it a common strategy to delay heart aging?

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