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Showing 1–50 of 65 results

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Time for lipid cell biology

It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders studying lipid cell biology from different perspectives to share what questions they are most interested in and what tools they believe the field is currently lacking.

Xiao-Wei Chen
Anthony S. Don
Yilong Zou
Reviews05 Feb 2025
Nature Cell Biology

Volume: 27, P: 169-174
Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan
Run-Cong Nie
Feng Wang
Amendments and Corrections08 Jan 2024
Nature Medicine

Volume: 30, P: 605
Anti-Markovnikov hydro- and deuterochlorination of unsaturated hydrocarbons using iron photocatalysis

Methods for the anti-Markovnikov-selective hydrochlorination of unsaturated C–C bonds are limited by the need for stoichiometric reagents, highly oxidizing photocatalysts and multiple synthetic steps. Now the combination of ligand-to-metal charge transfer and hydrogen atom transfer reactivity enables the anti-Markovnikov-selective hydro- and deuterochlorination of unsaturated hydrocarbons using iron photocatalysis.

Kang-Jie Bian
David Nemoto Jr
Julian G. West
Research02 Jan 2025
Nature Synthesis

Volume: 4, P: 314-326
Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

In the phase 2 trial NEOSUMMIT-01, perioperative treatment of patients with locally advanced gastric or gastro-esophageal junction adenocarcinoma with anti-PD-1 and SOX/XELOX versus SOX/XELOX alone improved pathological complete response or near-complete response rate.

Shu-Qiang Yuan
Run-Cong Nie
Feng Wang
Research02 Jan 2024
Nature Medicine

Volume: 30, P: 552-559
Mesenchymal stem cell-derived exosomes improve vascular remodeling by inhibiting EGFR/ErbB2 heterodimerization in hypoxic pulmonary hypertension

Yao-Xin Chen
Zhi-Hua Deng
Jin-Xian Qian
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Effects of orexins on myoelectric activity of sphincter of Oddi in fasted rabbits

Song-tao Li
Xiao-wei Chen
Zhi-an Hu
Research01 Feb 2006
Acta Pharmacologica Sinica

Volume: 27, P: 212-216
The association between the recurrence of atrial fibrillation and the shape of left atrial lateral ridge

Yu-Han Sun
Xin Tian
Cai-Ying Li
ResearchOpen Access03 Dec 2024
Scientific Reports

Volume: 14, P: 1-8
Manganese regulation of COPII condensation controls circulating lipid homeostasis

Wang et al. report that the secretory coat protein complex COPII undergoes liquid–liquid phase separation that is tuned by manganese in the cytosol, to impact lipoprotein secretion.

Xiao Wang
Runze Huang
Xiao-Wei Chen
Research26 Oct 2023
Nature Cell Biology

Volume: 25, P: 1650-1663
ID1 expressing macrophages support cancer cell stemness and limit CD8⁺ T cell infiltration in colorectal cancer

Inhibitor of differentiation 1 (ID1) has been described as a cancer-promoting factor and also involved in the formation of an immunosuppressive tumor microenvironment. Here the authors report that ID1-expressing tumor associated macrophages favor colorectal cancer progression by promoting cancer cell stemness and CD8⁺ T cell exclusion.

Shuang Shang
Chen Yang
Fang Hua
ResearchOpen Access23 Nov 2023
Nature Communications

Volume: 14, P: 1-19
Twins methods quantitatively explore the genetic impact on children and adolescents brain gray matter volume

Xiao-Lu Chen
Xiao-Wei Zhang
Tao Li
ResearchOpen Access13 Jul 2017
Scientific Reports

Volume: 7, P: 1-5
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

Zhu Chen, Sai-Juan Chen and colleagues report exome sequencing of acute monocytic leukemia, a subtype of acute myeloid leukemia. They identified somatic mutations of DNMT3A, which encodes a DNA methyltransferase, in 20% of cases.

Xiao-Jing Yan
Jie Xu
Sai-Juan Chen
Research13 Mar 2011
Nature Genetics

Volume: 43, P: 309-315
The foam cell-derived exosomal miRNA Novel-3 drives neuroinflammation and ferroptosis during ischemic stroke

Qin, Dong, Tang, Chu et al. profile exosomal miRNAs from patients with stroke who have atherosclerosis, identifying selective upregulation of Novel-3 in the plasma. Using a mouse model of cerebral ischemia, they demonstrate the foam cell origin of Novel-3 and explore its neuroinflammatory role.

Chuan Qin
Ming-Hao Dong
Dai-Shi Tian
Research28 Oct 2024
Nature Aging

Volume: 4, P: 1845-1861
Involvement of REST corepressor 3 in prognosis of human hepatitis B

Ji-hua Xue
Min Zheng
Feng Chen
Research18 Jul 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1019-1024
Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project

Biobanks of genetic data have been primarily in European populations, which gives us an incomplete understanding of complex traits across populations. Here, the authors initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole genome sequences and 5,841 high-density genotypes from China, characterizing large-scale genomic variation in Chinese populations.

Pei-Kuan Cong
Wei-Yang Bai
Hou-Feng Zheng
ResearchOpen Access26 May 2022
Nature Communications

Volume: 13, P: 1-15
Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)

Ectopic lipid accumulation and inflammation are the essential signs of NASH. Here, the authors show that hepatic WTAP is a key integrative repressor of ectopic lipid accumulation and inflammation during NASH progression, and hepatic deletion of Wtap promotes both of them, leading to NASH

Xinzhi Li
Kaixin Ding
Zheng Chen
ResearchOpen Access04 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Blood cell-produced amyloid-β induces cerebral Alzheimer-type pathologies and behavioral deficits

Hao-Lun Sun
Si-Han Chen
Yan-Jiang Wang
Research17 Jul 2020
Molecular Psychiatry

Volume: 26, P: 5568-5577
Photochemical diazidation of alkenes enabled by ligand-to-metal charge transfer and radical ligand transfer

The difunctionalization of alkenes allows for efficient construction of molecular complexity. Combining Ligand-to-Metal Charge transfer (LMCT) and Radical Ligand Transfer (RLT), the authors show a photochemical diazidation using iron salts, allowing rapid preparation of vicinal diamines and other privileged synthetic motifs.

Kang-Jie Bian
Shih-Chieh Kao
Julian G. West
ResearchOpen Access23 Dec 2022
Nature Communications

Volume: 13, P: 1-10
Preparation of Aluminum Nanomesh Thin Films from an Anodic Aluminum Oxide Template as Transparent Conductive Electrodes

Yiwen Li
Yulong Chen
Rui Chen
ResearchOpen Access02 Feb 2016
Scientific Reports

Volume: 6, P: 1-7
Reconstructed covalent organic frameworks

A protocol in which monomers are pre-organized using a reversible and removable urea linkage enables the production of covalent organic frameworks with higher crystallinity and porosity than those produced using standard approaches with randomly aligned monomers.

Weiwei Zhang
Linjiang Chen
Andrew I. Cooper
ResearchOpen Access06 Apr 2022
Nature

Volume: 604, P: 72-79
MiR-221/222 promote epithelial-mesenchymal transition by targeting Notch3 in breast cancer cell lines

Yuan-Ke Liang
Hao-Yu Lin
Guo-Jun Zhang
ResearchOpen Access06 Aug 2018
npj Breast Cancer

Volume: 4, P: 1-9
Quantum transport in fractal networks

Quantum transport in fractal networks is experimentally investigated by performing continuous-time quantum walks in fractal photonic lattices. Contrarily to classical fractals, anomalous transport governed solely by the fractal dimension is observed.

Xiao-Yun Xu
Xiao-Wei Wang
Xian-Min Jin
Research19 Jul 2021
Nature Photonics

Volume: 15, P: 703-710
TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation

c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a member of the pseudokinase family, tribbles homologue 3 (TRIB3), interacts with c-MYC to suppress c-MYC ubiquitination and degradation, leading to increased proliferation and self-renewal of lymphoma cells.

Ke Li
Feng Wang
Zhuo-wei Hu
ResearchOpen Access09 Dec 2020
Nature Communications

Volume: 11, P: 1-20
ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration

Xiao-Wei Liu
Hao-Wei Xu
Shan-Jin Wang
ResearchOpen Access04 Jun 2025
Cell Death Discovery

Volume: 11, P: 1-21
Pharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS

Le-Le Yang
Na Xiao
Lian-Wen Qi
ResearchOpen Access24 Oct 2016
Scientific Reports

Volume: 6, P: 1-9
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription

Cancer stem cells contribute to breast cancer metastasis and recurrence. Here the authors show that TRIB3 enhances breast cancer stemness through interaction with AKT to promote FOXO1 stability, which then increases SOX2 activity.

Jin-mei Yu
Wei Sun
Zhuo-Wei Hu
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-16
Sulfasalazine prevents apoptosis in spermatogenic cells after experimental testicular torsion/detorsion

Yu-gang Zhao
Xin-min Zheng
Zhi-yun Yu
Research01 May 2006
Acta Pharmacologica Sinica

Volume: 27, P: 603-608
Identification of novel therapeutic targets for cognitive performance and associations with brain health

Lu-Yang Zhang
Yu-Xin Liu
Dai-Shi Tian
ResearchOpen Access25 Jun 2025
Translational Psychiatry

Volume: 15, P: 1-11
Stable acyclic aliphatic solid enols: synthesis, characterization, X-ray structure analysis and calculations

Yu-Qiang Zhou
Nai-Xing Wang
Zhi-Xiang Wang
ResearchOpen Access14 Jan 2013
Scientific Reports

Volume: 3, P: 1-6
All Solution-processed Stable White Quantum Dot Light-emitting Diodes with Hybrid ZnO@TiO₂ as Blue Emitters

Jing Chen
Dewei Zhao
Xiao Wei Sun
ResearchOpen Access13 Feb 2014
Scientific Reports

Volume: 4, P: 1-6
Perioperative tislelizumab plus chemotherapy for locally advanced gastroesophageal junction adenocarcinoma (NEOSUMMIT-03): a prospective, nonrandomized, open-label, phase 2 trial

Run-Cong Nie
Shu-Qiang Yuan
Ying-Bo Chen
ResearchOpen Access05 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-9
Exocyst function regulated by effector phosphorylation

How do exocytic vesicles disengage from the exocyst complex? Phosphorylation of the RalA GTPase effector Sec5, rather than RalA inactivation per se, is now shown to mediate dissociation of the Sec5–RalA complex.

Xiao-Wei Chen
Dara Leto
Alan R. Saltiel
Research24 Apr 2011
Nature Cell Biology

Volume: 13, P: 580-588
Overexpression MsJAR1 gene increased lateral branches and plant height in alfalfa (Medicago sativa L.)

Rui Dai
Qi Chen
Zhi-qiang Zhang
ResearchOpen Access15 May 2025
Scientific Reports

Volume: 15, P: 1-14
Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis

Xiao-Wei Zhu
Yong Wang
Hou-Feng Zheng
ResearchOpen Access19 Aug 2016
Scientific Reports

Volume: 6, P: 1-13
The requirement of the mitochondrial protein NDUFS8 for angiogenesis

Qian-wei Xiong
Kun Jiang
Xu Cao
ResearchOpen Access09 Apr 2024
Cell Death & Disease

Volume: 15, P: 1-13
Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial

Jun-Wei Wu
Chen-Fei Zhou
Jun Zhang
ResearchOpen Access09 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-11
Adherence to the Mediterranean diet is associated with a higher BMD in middle-aged and elderly Chinese

Geng-dong Chen
Xiao-wei Dong
Yu-ming Chen
ResearchOpen Access09 May 2016
Scientific Reports

Volume: 6, P: 1-8
First-principles calculations of high-pressure physical properties anisotropy for magnesite

Zi-Jiang Liu
Xiao-Wei Sun
Neng-Zhi Jin
ResearchOpen Access07 Mar 2022
Scientific Reports

Volume: 12, P: 1-13
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia

Yu-jun Chen
Yu Zhao
Cheng-ying Xie
ResearchOpen Access30 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1390-1403
Real-time holographic camera for obtaining real 3D scene hologram

A real-time holographic camera for acquiring high-fidelity holograms of real 3D scenes based on a elastic membrane liquid camera and a focal stack network is proposed.

Zhao-Song Li
Chao Liu
Qiong-Hua Wang
ResearchOpen Access08 Feb 2025
Light: Science & Applications

Volume: 14, P: 1-11
Sustainable development between sports facilities and ecological environment based on the dual carbon background

Lin-Hong Zheng
Shu-Ting Guo
Nor Eeza Zainal Abidin
ResearchOpen Access30 Sept 2024
Scientific Reports

Volume: 14, P: 1-17
Discovery of new genetic loci for male sexual orientation in Han population

Shao-Hua Hu
Hai-mei Li
Yi Xu
ResearchOpen Access31 Oct 2021
Cell Discovery

Volume: 7, P: 1-14
Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca²⁺/CAMK II/ERK/NF-κB signaling pathway

Xiao-wei Ding
Xia Sun
Jia-wei Chen
Research24 Jun 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1303-1313
Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort

Guo-Tian Ruan
Hai-Lun Xie
Han-Ping Shi
ResearchOpen Access15 Mar 2023
Scientific Reports

Volume: 13, P: 1-13
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma

Zhong-jie Li
Hui-qi Dai
Guo-dong Lu
Research22 Jul 2020
Acta Pharmacologica Sinica

Volume: 42, P: 301-310
Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos

Dao-Rong Hou
Yong Jin
Rong-Feng Li
ResearchOpen Access13 May 2016
Scientific Reports

Volume: 6, P: 1-13
A first-in-class HBO1 inhibitor WM-3835 inhibits castration-resistant prostate cancer cell growth in vitro and in vivo

Yuan-yuan Mi
Yu Ji
Li-jie Zhu
ResearchOpen Access28 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-11
The importance of resource awareness in artificial intelligence for healthcare

Sustainability awareness is lacking in the development of AI systems and algorithms for healthcare. The authors discuss resource sustainability issues in energy, storage and domain knowledge, and present potential solutions.

Zhenge Jia
Jianxu Chen
Yiyu Shi
Reviews12 Jun 2023
Nature Machine Intelligence

Volume: 5, P: 687-698
Notch3 inhibits epithelial–mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression

Hao-Yu Lin
Yuan-Ke Liang
Guo-Jun Zhang
ResearchOpen Access13 Aug 2018
Oncogenesis

Volume: 7, P: 1-15
Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

Jun Wang
Bin-Lu Sun
Yan-Jiang Wang
ResearchOpen Access13 Jul 2020
Translational Psychiatry

Volume: 10, P: 1-12
Evaluation of dose-volume histogram prediction for organ-at risk and planning target volume based on machine learning

Sheng xiu Jiao
Ming li Wang
Xiao-wei Liu
ResearchOpen Access04 Feb 2021
Scientific Reports

Volume: 11, P: 1-9

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