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Showing 1–50 of 93 results

Advanced filters: Author: Xiao-yu Ma Clear advanced filters

Genome-resolved metagenomics reveals microbiome diversity across 48 tick species

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

Li-Feng Du
Wenyu Shi
Wu-Chun Cao
ResearchOpen Access23 Sept 2025
Nature Microbiology

Volume: 10, P: 2631-2645
Enantioselective reductive cross-couplings to forge C(sp²)–C(sp³) bonds by merging electrochemistry with nickel catalysis

Reductive cross-coupling of aryl chlorides or electron-rich aryl bromides with benzyl chlorides remains a significant challenge, presumably due to the lower reactivity of aryl chlorides or electron-rich aryl bromides with the nickel catalyst compared with aryl iodides. Here, the authors present Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity, without resorting to heterogeneous metal reductants or sacrificial anodes.

Yun-Zhao Wang
Bing Sun
Tian-Sheng Mei
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-8
LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis

Inhibition of immunocyte infiltration and activation has been suggested to ameliorate hepatic inflammation and fibrosis in nonalcoholic steatohepatitis. Here, the authors show PirB/LILRB2 regulates the migration of macrophages during NASH by binding with ANGPTL8, which is involved in the regulation of NASH development.

Dan-Pei Li
Li Huang
Xue-Feng Yu
ResearchOpen Access22 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Enrichment of two important metabolites d-galacturonic acid and d-glucuronic acid inhibits MdHb1-mediated fruit softening in apple

This study elucidates that d-galacturonic acid and d-glucuronic acid regulate apple fruit softening by repressing MdHb1 expression through the MdMYB2/MdNAC14/MdNTL9-MdHb1 regulatory module, offering new insights into postharvest fruit quality control.

Yu-Wen Zhao
Ting-Ting Zhao
Da-Gang Hu
Research17 Apr 2025
Nature Plants

Volume: 11, P: 891-908
Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers

The early pathophysiology of Parkinson’s disease is not well understood. Here the authors perform large-scale proteomic analyses of incident Parkinson’s disease to reveal pathophysiological insights and potential biomarkers, providing targets for early disease detection and guiding targeted therapeutic strategies.

Yi-Han Gan
Ling-Zhi Ma
Jin-Tai Yu
Research20 Feb 2025
Nature Aging

Volume: 5, P: 642-657
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment

Analysis of tumor samples from patients with nasopharyngeal carcinoma shows that gemcitabine plus cisplatin chemotherapy activates a unique population of innate-like B cells, which enhance the cytotoxic CD8⁺ T cell response and are associated with better clinical outcomes.

Jiawei Lv
Yuan Wei
Jun Ma
Research06 Jun 2023
Nature Medicine

Volume: 29, P: 1424-1436
Bacteria are important dimethylsulfoniopropionate producers in marine aphotic and high-pressure environments

Dimethylsulfoniopropionate (DMSP) is an osmolyte produced by marine microbes that plays an important role in nutrient cycling and atmospheric chemistry. Here the authors go to the Mariana Trench—the deepest point in the ocean—and find bacteria are key DMSP producers, and that DMSP has a role in protection against high pressure.

Yanfen Zheng
Jinyan Wang
Xiao-Hua Zhang
ResearchOpen Access16 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Neuropeptide Initiated Mast Cell Activation by Transcutaneous Electrical Acupoint Stimulation of Acupoint LI4 in Rats

Li-Zhen Chen
Yu Kan
Xiang-Hong Jing
ResearchOpen Access17 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1

Shi et al. show that following adrenergic signalling, PKA phosphorylates AIDA, which in turn interacts with and promotes oxidation of UCP1 to regulate UCP1-dependent adaptive thermogenesis.

Meng Shi
Xiao-Yu Huang
Sheng-Cai Lin
Research04 Mar 2021
Nature Cell Biology

Volume: 23, P: 268-277
PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 establishment.

Tie-Gang Meng
Qian Zhou
Qing-Yuan Sun
ResearchOpen Access11 Dec 2020
Nature Communications

Volume: 11, P: 1-12
Evidence for time-reversal symmetry-breaking kagome superconductivity

The authors use scanning tunnelling microscopy and muon spin resonance to demonstrate time-reversal symmetry-breaking superconductivity in Cs(V, Ta)₃Sb₅. The Cooper pairing in this state exhibits magnetism and is modulated by it.

Hanbin Deng
Guowei Liu
Jia-Xin Yin
Research28 Aug 2024
Nature Materials

Volume: 23, P: 1639-1644
Lipidomic profiling of human bile distinguishes cholangiocarcinoma from benign bile duct diseases with high specificity and sensitivity: a prospective descriptive study

Fu-Sheng Liu
Ying-Yi Liu
Yu-Feng Yuan
ResearchOpen Access02 Sept 2025
British Journal of Cancer

P: 1-18
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease

An-qi Dong
Ya-ping Yang
Chun-feng Liu
ResearchOpen Access27 Jul 2022
Acta Pharmacologica Sinica

Volume: 44, P: 32-43
N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance

Ming-Jian Ma
Yin-Hao Shi
Xiao-Yu Yin
ResearchOpen Access24 Jun 2024
Oncogene

Volume: 43, P: 2405-2420
Probing electrolyte effects on cation-enhanced CO₂ reduction on copper in acidic media

CO₂ electroreduction is promoted by alkali cations in the electrolyte, but the precise mechanism by which this occurs is not clear. Now in situ infrared spectroscopy and ab initio molecular dynamics are combined to elucidate the specific role of alkali cations and their trends.

Zhi-Ming Zhang
Tao Wang
Shi-Gang Sun
Research24 Jun 2024
Nature Catalysis

Volume: 7, P: 807-817
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling

Xiao-yu Shi
Yi-xi He
Zheng-hao Li
ResearchOpen Access26 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1610-1623
Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice

Tian Zhang
Preethy Prasad
Xiao Yu Wu
ResearchOpen Access20 Feb 2017
Acta Pharmacologica Sinica

Volume: 38, P: 835-847
Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3K/AKT pathway

Ying-luo Liu
Xiao-yu Zhou
Li-jiang Xuan
Research13 Feb 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1010-1018
Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells

Jing Liu
Qing-li Wu
Jian-ping Zuo
Research01 Feb 2005
Acta Pharmacologica Sinica

Volume: 26, P: 223-227
Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models

Xiao-Yu Zhu
Dian-Wu Guo
Ping Li
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulating ferroptosis-associated phospholipid remodeling in tumor-repopulating cells that are resistant to chemotherapy and radiotherapy.

Zhe Li
Zhi-min Xu
Zhuo-wei Liu
ResearchOpen Access08 May 2024
Nature Chemical Biology

Volume: 20, P: 1341-1352
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits

A genome-wide association study of cerebral ventricle phenotypes finds 62 unique loci and reveals a genetic overlap between ventricular and neuropsychiatric traits.

Yi-Jun Ge
Bang-Sheng Wu
Jin-Tai Yu
Research19 Oct 2023
Nature Human Behaviour

Volume: 8, P: 164-180
Self-assembled soft alloy with Frank–Kasper phases beyond metals

Soft building blocks tend to be near spherical, limiting their packing structures to those found in metallic systems. Here the authors report the spontaneous generation of highly deformed mesoatoms using molecular pentagons and observe Frank–Kasper phases not found in metal alloys.

Xian-You Liu
Xiao-Yun Yan
Stephen Z. D. Cheng
Research31 Jan 2024
Nature Materials

Volume: 23, P: 570-576
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ubc9.

Xue-li Bian
Hang-zi Chen
Qiao Wu
ResearchOpen Access27 Feb 2017
Nature Communications

Volume: 8, P: 1-14
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

Emerging SARS-CoV-2 variants raise concerns on immune evasion. Here, the authors evaluate the neutralization efficiency of COVID-19 mRNA vaccinee sera against representative viruses of 13 WHO-designated SARS-CoV-2 variants of concern/interest.

Li Wang
Markus H. Kainulainen
Bin Zhou
ResearchOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1-10
Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder

Zhong-lin Huang
Rui Liu
Guan-hua Du
Research16 Dec 2013
Acta Pharmacologica Sinica

Volume: 35, P: 24-32
Aging affects artemisinin synthesis in Artemisia annua

Jiao Li
Xiao-Hui Chu
Zong-Xia Yu
ResearchOpen Access28 May 2021
Scientific Reports

Volume: 11, P: 1-9
Transcriptional activation of insulin-like growth factor binding protein 6 by 17β-estradiol in SaOS-2 cells

Yu-yan Zhao
Lei Guo
Xiao-yu Gao
ResearchOpen Access31 Jul 2009
Experimental & Molecular Medicine

Volume: 41, P: 478-486
FGF-7 Dictates Osteocyte Cell Processes Through Beta-Catenin Transduction

Xiao-Yu Liu
Xin Li
Ling Ye
ResearchOpen Access04 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
CD147-high extracellular vesicles promote gastric cancer metastasis via VEGF/AKT/eNOS and AKT/mTOR pathways

Chen-li Zhang
Chan-yuan Zhao
Min Li
ResearchOpen Access20 Jun 2025
Oncogenesis

Volume: 14, P: 1-13
Butyrate improves abnormal sleep architecture in a Parkinson’s disease mouse model via BDNF/TrkB signaling

Wen-Xiang Duan
Wei-Ye Xie
Chun-Feng Liu
ResearchOpen Access19 Jun 2025
npj Parkinson's Disease

Volume: 11, P: 1-17
A novel cysteine desulfurase influencing organosulfur compounds in Lentinula edodes

Ying Liu
Xiao-Yu Lei
Wen Huang
ResearchOpen Access09 Jun 2015
Scientific Reports

Volume: 5, P: 1-9
Unveiling how intramolecular stacking modes of covalently linked dimers dictate photoswitching properties

Covalently bridged π-stacked dimers are excellent molecular platforms for understanding the relationship between stacking orientation and properties. Here, the authors synthesize a pair of π-stacked dimers that are aligned either cofacially or crosswise, allowing them to compare how the intramolecular stacking mode affects each dimer’s photoswitching properties.

Ru-Qiang Lu
Xiao-Yun Yan
Xiao-Yu Cao
ResearchOpen Access02 Dec 2019
Nature Communications

Volume: 10, P: 1-8
(5R)-5-hydroxytriptolide inhibits IFN-γ-related signaling

Ru Zhou
Jun-xia Wang
Jian-ping Zuo
Research01 Dec 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1616-1621
Dense dislocations enable high-performance PbSe thermoelectric at low-medium temperatures

Thermoelectric material is capable of realizing direct conversion between heat and electricity. Here, the authors obtain high thermoelectric performance in PbSe at low-medium temperatures by importing dense dislocations.

Liqing Xu
Yu Xiao
Li-Dong Zhao
ResearchOpen Access28 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Author Correction: Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

Peng-yu Duan
Yuan Ma
Gang Wang
Amendments and CorrectionsOpen Access09 Jun 2025
Experimental & Molecular Medicine

Volume: 57, P: 1341-1342
IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways

Le Han
Xian-zheng Zhang
Wei Wei
Research14 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 800-812
Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro

Guo-dong Yao
Jing Yang
Takashi Ikejima
Research26 Jun 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1401-1411
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression

Xiao-yu He
Meng-meng Zhu
Yuan-li Chen
Research22 Aug 2022
Acta Pharmacologica Sinica

Volume: 44, P: 635-646
Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia

Mao-feng Zhang
Xiao-yu Luo
Yan Zhang
Research09 Mar 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2735-2748
Active sites in the right places

Bifunctional catalysts containing metal and acid sites are used industrially in alkane hydroconversion. Now, the nanoscale spatial separation of the two active sites is shown to promote hydroisomerization and inspires design principles for this type of catalyst.

Si-Ming Wu
Jiří Čejka
Xiao-Yu Yang
News & Views22 Sept 2022
Nature Synthesis

Volume: 1, P: 757-758
Peroxiredoxin I and II as novel therapeutic molecular targets in cervical cancer treatment through regulation of endoplasmic reticulum stress induced by bleomycin

Hu-Nan Sun
Da-Yu Ma
Taeho Kwon
ResearchOpen Access31 May 2024
Cell Death Discovery

Volume: 10, P: 1-11
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice

Meng-yun Xu
Jing-jing Xu
Suo-wen Xu
Research17 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2277-2289
Calycosin synergizes with methotrexate in the treatment of Sjögren’s disease by targeting BATF in T follicular helper cells

Su-lan Yu
Mei-ling Wu
Xiang Lin
Research03 Apr 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1990-2005
Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli

Plasmid-encoded tet(X) genes from Escherichia coli in China confer high-level tigecycline resistance.

Jian Sun
Chong Chen
Ya-Hong Liu
Research24 Jun 2019
Nature Microbiology

Volume: 4, P: 1457-1464
Microemulsion-based drug delivery system identifies pepper alkaloids as anti-obesity compounds

Tian-kai Meng
Ruo-lei Han
Han-song Deng
Research20 Mar 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2310-2322
A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo

Wen-liang Zhou
Jin-ming Wu
Jian-ping Zuo
Research01 Nov 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1352-1358
Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis

Yu-zhen Zhang
Run-wei Ma
Li-ming Cheng
ResearchOpen Access22 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition

Yan-min Zhao
Qian Zhou
He Huang
Research01 Apr 2008
Acta Pharmacologica Sinica

Volume: 29, P: 481-488
Ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells

Jian-yun Wang
Xiao-xing Yin
Bei Zhang
Research01 Sept 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1222-1230

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