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Scientific Reports (16)
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Showing 1–50 of 60 results

Advanced filters: Author: Xiaohan He Clear advanced filters

Optimized in vivo base editing restores auditory function in a DFNA15 mouse model

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

Man Wang
Ziyu Zhang
Renjie Chai
ResearchOpen Access18 Sept 2025
Nature Communications

Volume: 16, P: 1-15
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Low-noise frequency synthesis and terahertz wireless communication driven by compact turnkey Kerr combs

High frequency microwave is crucial for communication and radar applications. The authors develop a compact Kerr comb for photonic THz generation with near quantum limited noise performance, enabling record-breaking 240 Gbps wireless communication.

Kunpeng Jia
Yuancheng Cai
Zhenda Xie
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-11
The Ailao Shan/Red River metamorphic belt: Tertiary left-lateral shear between Indochina and South China

P. Tapponnier
R. Lacassin
Zhong Jiayou
Research01 Feb 1990
Nature

Volume: 343, P: 431-437
Sex differences in systolic blood pressure response to exercise testing: a real-world clinical analysis

Shengming Li
Tianjing Zhang
Xiaohan Fan
Research30 Jun 2025
Journal of Human Hypertension

Volume: 39, P: 559-565
Author Correction: LINE-1 transcription activates long-range gene expression

Xiufeng Li
Luyao Bie
Nian Liu
Amendments and Corrections09 Jul 2024
Nature Genetics

Volume: 56, P: 1762
Examining the role of compression in influencing AI-generated image authenticity

Xiaohan Fang
Peilin Chen
Shiqi Wang
ResearchOpen Access09 Apr 2025
Scientific Reports

Volume: 15, P: 1-19
A neural network for long-term super-resolution imaging of live cells with reliable confidence quantification

A neural network model improves time-lapse super-resolution imaging of live cells.

Chang Qiao
Shuran Liu
Qionghai Dai
ResearchOpen Access29 Jan 2025
Nature Biotechnology

P: 1-10
Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants

Convergence of heavy or light chains in antibodies recognising pathogens could drive mutations in these pathogens. Here the authors examine antibodies against SARS-CoV-2 and find that a conserved VL6-57 light chain recognising a conserved motif in the spike protein is associated with virus mutations and could drive changes in SARS-CoV-2 omicron variants.

Qihong Yan
Xijie Gao
Xiaoli Xiong
ResearchOpen Access31 Aug 2024
Nature Communications

Volume: 15, P: 1-17
Induction and characterization of oral submucous fibrosis model with different pathological stages in rats and mice

Jianfei Tang
Zekun Zhou
Ousheng Liu
ResearchOpen Access24 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
LINE-1 transcription activates long-range gene expression

A CRISPR–Cas9 screen identifies genes that modulate long interspersed nuclear element-1 (LINE-1) expression in human cells. LINE-1 5′ UTRs have enhancer features and can activate long-range gene expression, including during zygotic genome activation.

Xiufeng Li
Luyao Bie
Nian Liu
Research07 Jun 2024
Nature Genetics

Volume: 56, P: 1494-1502
A pangenome reference of 36 Chinese populations

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Yang Gao
Xiaofei Yang
Shuhua Xu
ResearchOpen Access14 Jun 2023
Nature

Volume: 619, P: 112-121
Hierarchical fluctuation shapes a dynamic flow linked to states of consciousness

The neuroanatomical basis of consciousness is not fully understood. Here the authors show that a global state of consciousness might not depend on a specific brain region or location in Euclidean space; rather, it is linked to a low-dimensional dynamic pattern in topological space, as shown through the analysis of different experimental paradigms, imaging techniques, and species.

Ang Li
Haiyang Liu
Bing Liu
ResearchOpen Access05 Jun 2023
Nature Communications

Volume: 14, P: 1-20
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

The chromatin accessibility landscape and gene regulatory network of pancreatic cancer has not been fully characterised. Here, the authors perform multi-omics analysis of 84 pancreatic cancer organoid lines and reveal gene regulatory networks and distinct molecular subtypes.

Xiaohan Shi
Yunguang Li
Dong Gao
ResearchOpen Access21 Apr 2022
Nature Communications

Volume: 13, P: 1-16
Author Correction: Inducible overexpression of Ideal Plant Architecture1 improves both yield and disease resistance in rice

Mingming Liu
Zhenying Shi
Dong-Lei Yang
Amendments and Corrections16 May 2019
Nature Plants

Volume: 5, P: 902
Multifunctional human visual pathway-replicated hardware based on 2D materials

Realizing complex functions in artificial visual systems is challenging. Here, the authors report a human visual pathway-replicated hardware with a split floating gate crossbar arrays and related peripheral circuits, achieving colour-blindness processing, shape recognition, and self-driven motion tracking.

Zhuiri Peng
Lei Tong
Lei Ye
ResearchOpen Access05 Oct 2024
Nature Communications

Volume: 15, P: 1-9
Electrocatalytic water oxidation with manganese phosphates

Understanding water oxidation on Mn-based catalysts remains a long-standing challenge. Here, the authors use homologous KMnPO₄ and KMnPO₄•H₂O as model catalyst to show that Mn(V)=O is responsible for O−O bond formation and its concentration determines the intrinsic activity.

Shujiao Yang
Kaihang Yue
Wei Zhang
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-13
DDR1 promotes metastasis of cervical cancer and downstream phosphorylation signal via binding GRB2

Jin Zhang
Aynuer Maimaiti
Xiaohan Chang
ResearchOpen Access20 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-12
Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis

Yueyi Yang
Xuchen Hu
Zhengwei Huang
ResearchOpen Access26 May 2025
International Journal of Oral Science

Volume: 17, P: 1-12
Minimizing heat generation in quantum dot light-emitting diodes by increasing quasi-Fermi-level splitting

Quantum dot LED brightness can be enhanced at low driving voltage using a monolayer of large quantum dots to reduce the packing number in the emitting layer and minimize heat generation.

Yan Gao
Bo Li
Zuliang Du
Research20 Jul 2023
Nature Nanotechnology

Volume: 18, P: 1168-1174
Real-world study of first-line immunotherapy combined with chemoradiotherapy in esophageal squamous cell carcinoma

Xiaohan Zhao
Chengang Weng
Wenbin Shen
ResearchOpen Access04 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Evidence of a coupled electron-phonon liquid in NbGe₂

It was predicted that in the regime of strong electron-phonon interactions, electrons and phonons can form a coupled non-equilibrium state, characterized by the conservation of the total momentum and by hydrodynamic transport. Here, the authors report experimental evidence for such a coupled electron-phonon liquid in NbGe₂.

Hung-Yu Yang
Xiaohan Yao
Fazel Tafti
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-7
ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin

EGFR is a well-known oncogene; however, the mechanisms regulating its expression are still unclear. Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex.

Lifang Li
Xinhua Liu
Luyang Sun
ResearchOpen Access25 Sept 2017
Nature Communications

Volume: 8, P: 1-17
Inducible overexpression of Ideal Plant Architecture1 improves both yield and disease resistance in rice

Breeding crops with both high yield and disease resistance remains challenging. A study has now identified microRNA-156–Ideal Plant Architecture1 (IPA1) as a regulator of the crosstalk between growth and defence in rice and overcame the trade-off by pathogen-induced expression of IPA1.

Mingming Liu
Zhenying Shi
Dong-Lei Yang
Research18 Mar 2019
Nature Plants

Volume: 5, P: 389-400
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.

William Villiers
Audrey Kelly
Cameron S. Osborne
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-17
Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress

Despite common use as a diabetes mellitus supplement, chromium(III)’s pharmacological effects remain unknown. We identified the Cr(III)-proteome in cells with a metalloproteomic approach and uncovered ATP synthase as a vital target to relieve hyperglycaemia stress.

Haibo Wang
Ligang Hu
Hongzhe Sun
ResearchOpen Access28 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells

Danping Sun
Xiaohan Cui
Wenbin Yu
ResearchOpen Access26 Mar 2025
Cell Death & Disease

Volume: 16, P: 1-17
Multi-omics analysis of two rat models reveals potential role of vesicle transport and autophagy in right ventricular remodeling

Yuhan Qin
Jing Zhang
Xiaoxiao Guo
ResearchOpen Access18 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
The secreted protease ADAMTS18 is a novel activator of latent TGF-β to exacerbate renal fibrosis

Analysis of chronic kidney disease transcriptomics data and an experiment focused on a male mouse model of kidney fibrosis shed light on the role of ADAMS18 in TGF-β-induced fibrosis

Min Wang
Fangmin Xu
Wei Zhang
ResearchOpen Access07 Jun 2025
Communications Biology

Volume: 8, P: 1-20
Montmorillonite immobilized Fe/Ni bimetallic prepared by dry in-situ hydrogen reduction for the degradation of 4-Chlorophenlo

Shuo-Shuo Zhang
Ning Yang
Jinhua Zhan
ResearchOpen Access16 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
The pineapple genome and the evolution of CAM photosynthesis

Ray Ming, Robert Paull, Qingyi Yu and colleagues report the genome sequences of two cultivated pineapple varieties and one wild pineapple relative. Their analysis supports the use of the pineapple as a reference genome for monocot comparative genomics and provides insight into the evolution of crassulacean acid metabolism photosynthesis.

Ray Ming
Robert VanBuren
Qingyi Yu
ResearchOpen Access02 Nov 2015
Nature Genetics

Volume: 47, P: 1435-1442
PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells

Hong Zhu
Wenjuan Jiang
Cheng Huang
ResearchOpen Access12 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-13
Single-molecule long-read sequencing facilitates shrimp transcriptome research

Digang Zeng
Xiuli Chen
Xiaohan Chen
ResearchOpen Access16 Nov 2018
Scientific Reports

Volume: 8, P: 1-9
METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma

Xiaohan Jin
Yongrui Lv
Muyan Cai
ResearchOpen Access29 Oct 2024
Cell Death & Differentiation

Volume: 32, P: 466-479
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release

Chanjun Sun
Kaishang Zhang
Zhihai Qin
ResearchOpen Access29 Mar 2023
Oncogenesis

Volume: 12, P: 1-16
Excitation–transcription coupling, neuronal gene expression and synaptic plasticity

Synaptic or neuronal activity can trigger transcriptional changes in the nucleus that are important for learning and memory. Tsien, Ma and co-workers here provide a comprehensive review of the complex signalling pathways involved in this excitation–transcription coupling.

Huan Ma
Houda G. Khaled
Richard W. Tsien
Reviews29 Sept 2023
Nature Reviews Neuroscience

Volume: 24, P: 672-692
Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination

Xiangfei Sun
Qiang Zhang
Kuntang Shen
ResearchOpen Access18 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-15
Platelet-derived exosomes regulate endothelial cell inflammation and M1 macrophage polarization in coronary artery thrombosis via modulating miR-34a-5p expression

Kangkang Wei
Lintong Yu
Xiaojuan Ma
ResearchOpen Access29 Jul 2024
Scientific Reports

Volume: 14, P: 1-15
Reduction of renal interstitial fibrosis by targeting Tie2 in vascular endothelial cells

Lu Jiang
Xiaohan Hu
Xiaozhong Li
ResearchOpen Access27 Nov 2023
Pediatric Research

Volume: 95, P: 959-965
Synthesis vs. salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondii

A genetic and lipidomic investigation reveals that depletion of ECT in Toxoplasma gondii disrupts ester-phosphatidylethanolamine (PtdEtn) synthesis and results in parasite death. Notably, T. gondii salvages ether-PtdEtn from its host cells.

Bingjian Ren
Xiaohan Liang
Nishith Gupta
ResearchOpen Access22 Mar 2023
Communications Biology

Volume: 6, P: 1-14
RETRACTED ARTICLE: Chondro-protective effects of polydatin in osteoarthritis through its effect on restoring dysregulated autophagy via modulating MAPK, and PI3K/Akt signaling pathways

Zhengyuan Wu
Zhiwei Luan
Jun Yao
ResearchOpen Access25 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Small extracellular vesicles containing miR-30a-3p attenuate the migration and invasion of hepatocellular carcinoma by targeting SNAP23 gene

Chengdong Liu
Xiaohan Zhou
Li Liu
Research27 Oct 2020
Oncogene

Volume: 40, P: 233-245
Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma

Yanling Lin
Xiaohan Zhou
Longmei Cai
ResearchOpen Access06 Apr 2021
Oncogene

Volume: 40, P: 3101-3117
Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling

Xiaohan Hu
Li Li
Yunyun Xu
ResearchOpen Access06 Feb 2023
Cell Death Discovery

Volume: 9, P: 1-13
POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6

Wenshuo Yang
Xiaohan Cui
Wenbin Yu
ResearchOpen Access07 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-15
Autophagy activation contributes to lipid accumulation in tubular epithelial cells during kidney fibrosis

Qi Yan
Yuan Song
Huiming Wang
ResearchOpen Access27 Jun 2018
Cell Death Discovery

Volume: 4, P: 1-14
NEU4 inhibits motility of HCC cells by cleaving sialic acids on CD44

Xiaoqing Zhang
Peng Dou
Yu Li
Research19 Jul 2021
Oncogene

Volume: 40, P: 5427-5440
Modification of distinct ion channels differentially modulates Ca²⁺ dynamics in primary cultured rat ventricular cardiomyocytes

Xichun Li
Liping Shen
Zhengyu Cao
ResearchOpen Access19 Jan 2017
Scientific Reports

Volume: 7, P: 1-14
Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis

Lin He
Xinhua Liu
Yongfeng Shang
Research22 Aug 2018
Cell Research

Volume: 28, P: 934-951
FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system

Yangyang Zhu
Hao Zhang
Longping Wen
Research14 Sept 2022
Cell Death & Differentiation

Volume: 30, P: 168-183

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