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Showing 1–50 of 66 results

Advanced filters: Author: Xiaohua Lei Clear advanced filters

Preoperative neutrophil percentage-to-albumin ratio as a postoperative AKI predictor in non-cardiac surgery: a retrospective cohort secondary analysis

Lei Lei
Yuling Liang
Xiaohua Wang
ResearchOpen Access31 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly

In this study, the authors perform an interactome study of Zika virus (ZIKV) 5’UTR stem-loop B region and identify two host factors, interleukin enhancer binding factor 3 (ILF3) and DEAH-box helicase 9 (DHX9), that positively regulate antiviral RNAi to inhibit virus replication and ZIKV-induced microcephaly in vivo.

Zhiwei Lei
Yu Gu
Xin Chen
ResearchOpen Access26 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Portal hypertension contributes to ascites formation via the Piezo1−nuclear factor kappa-B−aquaporin1 pathway in liver cirrhosis

Ning Wei
Li Du
Yuhu Song
ResearchOpen Access01 Oct 2025
Experimental & Molecular Medicine

P: 1-12
Symmetric inheritance of parental histones contributes to safeguarding the fate of mouse embryonic stem cells during differentiation

Mcm2 mutation or Pole3 deletion in mouse embryonic stem cells leads to asymmetric parental histone distribution and impaired neural differentiation. Mutation of the Mcm2 histone-binding domain causes defects in pre-implantation development and embryonic lethality.

Qing Wen
Jiaqi Zhou
Haiyun Gan
Research04 Sept 2023
Nature Genetics

Volume: 55, P: 1555-1566
Author Correction: Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Defang Li
Jin Liu
Ge Zhang
Amendments and CorrectionsOpen Access19 Jun 2025
Nature Communications

Volume: 16, P: 1-3
Publisher Correction: Complementary Alu sequences mediate enhancer–promoter selectivity

Liang Liang
Changchang Cao
Yuanchao Xue
Amendments and Corrections31 Jul 2023
Nature

Volume: 620, P: E26
Cloning of the wheat leaf rust resistance gene Lr47 introgressed from Aegilops speltoides

Leaf rust is one of the most severe foliar diseases of wheat. Here, the authors report the cloning of Lr47, a broadly effective leaf rust resistance gene introgressed into wheat from Aegilops speltoides, and show it encodes a coiled-coil nucleotide-binding leucine-rich repeat protein.

Hongna Li
Lei Hua
Shisheng Chen
ResearchOpen Access28 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Direct visualization of the Jahn–Teller effect coupled to Na ordering in Na_5/8MnO₂

The Jahn–Teller distortion is an electronic effect that is known to couple charge, orbital and magnetic ordering phenomena in many complex solids. Using a combination of scattering and microscopy approaches, it is now shown that cooperative Jahn–Teller distortions in Na_5/8MnO₂ are coupled to an unusual ordering of Na vacancies.

Xin Li
Xiaohua Ma
Gerbrand Ceder
Research18 May 2014
Nature Materials

Volume: 13, P: 586-592
Histone deacetylase inhibitor attenuates experimental fungal keratitis in mice

Xiaohua Li
Min Yuan
Shikun He
ResearchOpen Access08 Jul 2019
Scientific Reports

Volume: 9, P: 1-10
Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates

No male contraceptive pills are currently available. Here, the authors use triptonide, a compound derived from a Chinese plant, to deform sperm so that they cannot move properly, thereby causing reversible infertility in male mice and monkeys.

Zongliang Chang
Weibing Qin
Wei Yan
ResearchOpen Access23 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis

Xue Zhang, Jing Yu Liu and colleagues report SLC20A2 mutations in familial idiopathic basal ganglia calcification (IBGC, also known as Fahr disease). These mutations impair the function of the type III phosphate transporter encoded by SLA20A2 and may disturb phosphate homeostasis in the body.

Cheng Wang
Yulei Li
Jing-Yu Liu
Research12 Feb 2012
Nature Genetics

Volume: 44, P: 254-256
Complementary Alu sequences mediate enhancer–promoter selectivity

Using RNA in situ conformation sequencing technology, the role of Alu elements in mediating the interaction between enhancers and promoters is shown.

Liang Liang
Changchang Cao
Yuanchao Xue
Research12 Jul 2023
Nature

Volume: 619, P: 868-875
RIC-seq for global in situ profiling of RNA–RNA spatial interactions

RNA in situ conformation sequencing (RIC-seq) enables the generation of three-dimensional interaction maps of RNA in cells, which sheds light on the interactions and regulatory functions of RNA.

Zhaokui Cai
Changchang Cao
Yuanchao Xue
Research06 May 2020
Nature

Volume: 582, P: 432-437
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Jingyun Yang
Wei Wang
Xiawei Wei
Research29 Jul 2020
Nature

Volume: 586, P: 572-577
Manipulating microRNA miR408 enhances both biomass yield and saccharification efficiency in poplar

Modifying plant lignin pathway to enhance saccharification efficiency is often associated with growth penalty. Here, the authors show that overexpression of Pag-miR408 in poplar leads to enhanced saccharification efficiency and growth in both laboratory and field conditions, and laccase genes are the targets of Pag-miR408.

Yayu Guo
Shufang Wang
Jinxing Lin
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-15
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

Biochemical and structural studies of the interactions between antibodies and spike proteins from SARS-CoV-2 Omicron subvariants indicate how these variants have evolved to escape antibody-mediated neutralization.

Yunlong Cao
Ayijiang Yisimayi
Xiaoliang Sunney Xie
ResearchOpen Access17 Jun 2022
Nature

Volume: 608, P: 593-602
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

Cai He
Jingyun Yang
Xiawei Wei
ResearchOpen Access17 Sept 2022
Nature Communications

Volume: 13, P: 1-14
Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Li Jiang
Zijing Du
Yijun Hu
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-7
Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults

Li Jiang
Zijing Du
Yijun Hu
ResearchOpen Access27 Feb 2024
Scientific Reports

Volume: 14, P: 1-7
Neutron transport calculation for the BEAVRS core based on the LSTM neural network

Changan Ren
Li He
Tao Yu
ResearchOpen Access06 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

Xiaohua Lei
Qiang Liu
Xundi Xu
ResearchOpen Access16 Dec 2022
Cell Death & Disease

Volume: 13, P: 1-10
Translational control by DHX36 binding to 5′UTR G-quadruplex is essential for muscle stem-cell regenerative functions

Skeletal muscle stem cells (or satellite cells, SCs) are normally quiescent but activate and expand in response to injury. Here the authors show that induction of DHX36 helicase during SC activation promotes mRNA translation by binding to 5′UTR mRNA G-quadruplexes (rG4) in targets including Gnai2 and unwinding them.

Xiaona Chen
Jie Yuan
Huating Wang
ResearchOpen Access19 Aug 2021
Nature Communications

Volume: 12, P: 1-22
Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

The precise cellular patterning and decisions of early embryogenesis have been hard to mimic in vitro. Here, the authors culture murine embryonic and trophoblast stem cells together with extra-embryonic endoderm stem cells to form embryo-like structures (ETX-embryoids), which can initiate an implantation response.

Shaopeng Zhang
Tianzhi Chen
Jianyong Han
ResearchOpen Access30 Jan 2019
Nature Communications

Volume: 10, P: 1-17
The concerted roles of FANCM and Rad52 in the protection of common fragile sites

Fanconi anemia core proteins have been linked to common fragile site stability. Here the authors shed light into the role of FANCM in common fragile site protection by suppressing double-strand break formation and mitotic recombination.

Hailong Wang
Shibo Li
Xiaohua Wu
ResearchOpen Access18 Jul 2018
Nature Communications

Volume: 9, P: 1-14
A multicenter study of the distribution pattern of posterior corneal astigmatism in Chinese myopic patients having corneal refractive surgery

Yijun Hu
Shanqing Zhu
Zheng Wang
ResearchOpen Access30 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

In previous studies the authors discovered that miR-214 inhibits osteoblastic bone formation. Here they extend on these findings, using ovariectomized mice and samples from patients with bone fractures, to show that miR-214 is a mediator of osteoclast-osteoblast crosstalk.

Defang Li
Jin Liu
Ge Zhang
ResearchOpen Access07 Mar 2016
Nature Communications

Volume: 7, P: 1-16
GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

Huashan Zhao
Jingqiao Qiao
Enkui Duan
ResearchOpen Access21 Jan 2015
Scientific Reports

Volume: 5, P: 1-6
Ultrafast Synaptic Events in a Chalcogenide Memristor

Yi Li
Yingpeng Zhong
Xiangshui Miao
ResearchOpen Access08 Apr 2013
Scientific Reports

Volume: 3, P: 1-7
The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods

Scorpions have maintained the primary anatomical features of their Paleozoic arthropod ancestors. Here, the authors report the genome sequence of Mesobuthus martensiiand highlight evidence of genetic and morphological evolution that represents a unique adaptation model of arthropods.

Zhijian Cao
Yao Yu
Wenxin Li
ResearchOpen Access15 Oct 2013
Nature Communications

Volume: 4, P: 1-10
Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang
Wei Wang
Xiawei Wei
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E23
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

Zhang et al. report that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring.

Yunfang Zhang
Xudong Zhang
Qi Chen
Research25 Apr 2018
Nature Cell Biology

Volume: 20, P: 535-540
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes

Juan Chen
Zhaokui Cai
Yuanchao Xue
ResearchOpen Access24 Aug 2018
Cell Research

Volume: 28, P: 981-995
HRD effects on first-line adjuvant chemotherapy and PARPi maintenance therapy in Chinese ovarian cancer patients

Lei Li
Yu Gu
Han Liang
ResearchOpen Access31 May 2023
npj Precision Oncology

Volume: 7, P: 1-10
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

Chao Liang
Baosheng Guo
Ge Zhang
Research09 Feb 2015
Nature Medicine

Volume: 21, P: 288-294
Effects of variable-temperature heat reservoirs on performance of irreversible Carnot refrigerator with heat recovery

Zhe Zhang
Huan Su
Liping Zeng
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-17
Neurotoxicity induced by zinc oxide nanoparticles: age-related differences and interaction

Lei Tian
Bencheng Lin
Zhuge Xi
ResearchOpen Access03 Nov 2015
Scientific Reports

Volume: 5, P: 1-12
Mindfulness practice for protecting mental health during the COVID-19 pandemic

Julie Lei Zhu
Rasmus Schülke
Shouyan Wang
ResearchOpen Access28 May 2021
Translational Psychiatry

Volume: 11, P: 1-11
SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma

Zhongyi Fan
Jingjing Duan
Xiaojie Xu
ResearchOpen Access11 Apr 2022
Cell Death & Disease

Volume: 13, P: 1-11
CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest

Ze Chen
Xiaohua Xie
Yongjun Zhang
ResearchOpen Access15 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-14
Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells

Kaixin Cheng
Xie’an Feng
Yan Zhang
ResearchOpen Access23 Jan 2023
npj Microgravity

Volume: 9, P: 1-10
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Weiqi Hong
Jingyun Yang
Xiawei Wei
ResearchOpen Access10 Mar 2022
Cellular & Molecular Immunology

Volume: 19, P: 577-587
Intracranial direct electrical mapping reveals the functional architecture of the human basal ganglia

Direct electrical stimulation of the basal ganglia using implanted SEEG electrodes produced a variety of motor and non-motor effects in human participants, providing insight into the functional architecture of this key brain region.

Lei Qi
Cuiping Xu
Liankun Ren
ResearchOpen Access23 Oct 2022
Communications Biology

Volume: 5, P: 1-10
Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Zhihui Dou
Huiwen Lei
Cuixia Di
ResearchOpen Access21 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-11
Comparison of non-invasive biomarkers faecal BAFF, calprotectin and FOBT in discriminating IBS from IBD and evaluation of intestinal inflammation

Yu Fu
Lingli Wang
Xiaohua Hou
ResearchOpen Access01 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

J. Yuyang Lu
Lei Chang
Xiaohua Shen
ResearchOpen Access29 Jan 2021
Cell Research

Volume: 31, P: 613-630
Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer

Jin Liu
Defang Li
Ge Zhang
ResearchOpen Access10 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
QTL meta-analysis of root traits in Brassica napus under contrasting phosphorus supply in two growth systems

Ying Zhang
Catherine L. Thomas
Jinling Meng
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication

Jie Fu
Guoxing Liu
Xundi Xu
Research06 Jan 2023
Cancer Gene Therapy

Volume: 30, P: 738-751
Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

Xiaohua Lei
Qiang Liu
Xundi Xu
Amendments and CorrectionsOpen Access20 Mar 2023
Cell Death & Disease

Volume: 14, P: 1
TRIM32 promotes radioresistance by disrupting TC45-STAT3 interaction in triple-negative breast cancer

Yan Ma
Haibo Zhang
Jianming Tang
Research28 Jan 2022
Oncogene

Volume: 41, P: 1589-1599

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