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Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are uncommon mesenchymal neoplasms with limited treatment options. Here, the authors perform a multi-omics analysis of 189 cases of CNS SFTs to identify potential clinical biomarkers and therapeutic targets.

A self-floating photocatalytic film enables rapid bacterial inactivation under weak natural sunlight.

Employing appropriate catalysts in room-temperature sodium-sulfur batteries can significantly enhance performance. Here, authors utilize natural language processing techniques in conjunction with a binary descriptor to screen preferrable single-atom catalysts to achieve high specific capacity.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Polycystic ovary syndrome is a common cause of female infertility linked to metabolic and hormonal imbalances. Here, the authors show that androgen driven SLC1A5 upregulation increases glutamine uptake, leading to abnormal follicular development in PCOS via histone deacetylation.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Quantum memories usually suffer from a trade-off between efficiency and excess noise. Here, by exploiting the time-reversal approach for improving modes matching, the authors show a warm-atomic-cell-based cavity-enhanced memory with 67% efficiency and noise level close to quantum noise limit.

Minimizing the non-radiative energy loss without sacrificing the charge collection efficiency is the key to improve the performance of organic solar cells. Here, the authors develop hybrid side chain-based asymmetric small molecule acceptors and achieve maximum power conversion efficiency of 19.76%.

The Pacific white shrimp Litopenaeus vannamei is an important aquaculture species and a promising model for crustacean biology. Here, the authors provide a reference genome assembly, and show that gene expansion is involved in the regulation of frequent molting as well as benthic adaptation of the shrimp.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

This study of Chinese endometrioid endometrial carcinomas describes the proteogenomic differences between early-onset and late-onset tumors, finding that SIGLEC10 mutation may contribute to tumorigenesis and progestin resistance in early cases.

The interactions between tertiary lymphoid structures (TLS) and tumor cell aggregates remain to be investigated. Here, single-cell and spatial transcriptomics reveal the cellular composition, formation, and function of TLS during tumour progression and immunotherapy response in nasopharyngeal carcinoma.

Solitary fibrous tumours are mesenchymal tumours with an unpredictable progression and current medical treatments for relapsed SFTs remain ineffective. Here, the authors identified potential therapeutic targets and risk factors for SFTs and created an integrated risk model using 101 patients, and validated in 3 independent cohorts to successfully predict tumour progression.

Lin et al. show that MCM8 protects vascular health by mediating nitric-oxide-dependent mitophagy. The common East-Asian MCM8-P276 variant is ineffective in mitophagy, which potentiates cGAS-STING and type I interferon signaling in a mouse model of Kawasaki disease.

The genome of the tropical blue-petal water lily Nymphaea colorata and the transcriptomes from 19 other Nymphaeales species provide insights into the early evolution of angiosperms.

Zhou and colleagues find that GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity.

The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.

Brachyurans, or crabs, are of commercial and ecological importance, but limited genomic resources exist. Here the authors present a chromosome-level genome and expression data for the Chinese mitten crab, to shed light on the biology of this group.

Ytterbium oxide buffer layer for use in perovskite solar cells yields a certified power conversion efficiency of more than 25%, which enhances stability across a wide variety of perovskite compositions.

Manufacturing of perovskite solar cells under ambient conditions is desirable. Meng et al. show that dimethylammonium formate suppresses halide oxidation and deprotonation of organic cations, enabling air-processed inverted solar cells with 24.7% efficiency.

Solar-powered, untethered, sustained flight of an ultralight micro aerial vehicle under natural sunlight conditions is achieved using an electrostatic-driven propulsion system with a high lift-to-power efficiency.

The increase in detoxification gene expression is a common transcriptome marker for longevity interventions. Here, the authors show that nomilin extends lifespan and healthspan in animals through activation of PXR regulated detoxification functions.

Zero thermal expansion (ZTE) alloys with multi-properties are important for high-precision applications, but scarce. Here the authors incorporate a boron-migration-mediated solid-state reaction to construct a dual-phase ZTE alloy with enhanced mechanical properties and cyclic thermal stabilities.

Shigella flexneri IcsB encodes a fatty acyltransferase that targets membrane-associated proteins during infection.

The BHMbot provides an efficient running gait and a novel actuation mechanism for insect scale legged microrobots to solve the bottleneck problem of the severe running speed degradation after carrying essential payloads for untethered locomotion.

Realizing robust ferromagnetic order in two dimensions is challenging as an underlying crystalline framework is normally required. Now room-temperature ferromagnetism is demonstrated in a two-dimensional honeycomb self-assembly of confined molecules.

Zero thermal expansion materials play an increasingly important role in modern high-precision applications, but they are relatively scarce. Here, the authors achieve an isotropic zero thermal expansion with a very high toughness by manipulating chemical partitioning in chemically complex alloys.

The molecular mechanisms of lung cancer metastasis remain incompletely understood. Here the authors show that the transcription factor ZBTB11 drives metastasis in preclinical models of lung cancer both through SE translocation (SET)-dependent and independent manner.

Zwitterionic hydrogels are nonfouling and hemocompatibility but several key challenges such as weak mechanical strength and low adhesion hamper their application as coating materials for devices. Here, the authors report a microgel reinforced zwitterionic hydrogel with excellent mechanical robustness and anti-swelling properties.

Bacteria have evolved proteinaceous microcompartments (BMCs) to control the passage of metabolites and facilitate catabolism in a micro-environment. Here, Yang et al. apply fluorescence microscopy to characterize the protein-protein interaction and assembly involved in the de novo biogenesis of propanediol-utilization (Pdu) metabolosomes and show that Pdu BMCs undergo a combination of ‘Shell first’ and ‘Cargo first’ assembly.

Whole-genome resequencing of 418 diverse rapeseed accessions and genome-wide association analyses for 56 agronomic traits provide insights into the genetic architecture and artificial selection or adaptation during modern rapeseed breeding.

While the prognostic role of immunoglobulin heavy chain locus (IGH) rearrangement in minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has been reported, the contribution of light chain loci (IGK/IGL) remains elusive. Here, the authors investigate it using a next generation sequencing approach.

SOX2 amplification and overexpression represents a hallmark of squamous cancers with distinct distribution of chromatin accessible regions depending on cancer type. Here, the authors identify a single enhancer e1 that predominantly drives SOX2 expression in squamous cancer.

Non-fullerene organic molecule acceptors have been the hot research subject to drive the efficiency of the organic solar cells higher, but their synthetic costs are high. Here Li et al. design a simplified synthetic route for the state-of-the-art acceptors and bring down their cost by more than 15%.

Angiogenesis has been implicated in fibrotic diseases of the liver. Here, the authors developed microniches that mimic angiogenesis during different stages of liver fibrosis, and demonstrate the role of mechanotransduction in fibrogenesis.