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The integration of two-dimensional semiconductors and arbitrary materials or architectures offers the possibility to enhance the functionality of a material and improve device performance. Now, a general synthesis route is reported for heteroepitaxial growth of semiconducting 2H-MoTe₂ films on arbitrary single-crystal substrates and three-dimensional architectures without the limitation of lattice matching and a planar surface.

Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.

The bulk photovoltaic effect (BPVE) is a nonlinear optical effect offering a promising approach to overcome the limitations of conventional photovoltaics. Here, the authors report the observation of BPVE-induced photocurrents at the edges of 2D semiconductors embedded in various van der Waals heterostructures.

Esophageal squamous cell carcinoma (ESCC) is highly prevalent in China. Here, the authors carry out multi-region sampling of Chinese ESCC samples, and find recurrent ERBB4 mutations, BRCA1/2 variants, and amplification of CD274; together with high levels of genomic and T-cell receptor heterogeneity.

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

This study finds that projections of future extreme precipitation can be made more reliable using a constraint from observed present-day precipitation variability, which reduces projection uncertainty by 20–40% over the extra-tropics.

A family of single-atom catalysts synthesized by intercalating metal single atoms into the van der Waals gap of two-dimensional SnS₂ is reported. The materials are applied as hydrogen evolving catalysts with good durability and overpotential.

The kagome superconductor CsV₃Sb₅ exhibits a charge density wave (CDW) as well as superconductivity (SC). Here, the authors find that the CDW transition temperature decreases with decreasing sample thickness to 72 K at 27 atomic layers, but then unexpectedly increases to 120 K at 5 layers, an opposite trend to SC.

Mutations in the ZmDMP gene induce maternal haploids and facilitate breeding in maize. Now, a study extends this system of maize to dicots, showing that loss-of-function mutations in the Arabidopsis ZmDMP-like genes also induce maternal haploids.

Wiring photosynthetic biomachineries to electrodes is promising for sustainable bio-electricity and fuel generation, but designing such interfaces is challenging. Aerosol jet printing is now used to generate hierarchical pillar array electrodes using indium tin oxide nanoparticles for high-performance semi-artificial photosynthesis.

Tumor recurrence after surgical resection is associated with a poor clinical outcome. Here the authors design a manganese dioxide-based nanosystem to increase response to radio-immunotherapy by relieving tumor hypoxia and targeting myeloid cells, showing reduced post-surgical cancer recurrence and metastasis.

Van der Waals materials exhibit unique thermomechanical properties, but interlayer deformations are usually challenging to measure. Here, the authors exploit the strain-dependent optical properties of monolayer WSe₂ to quantitatively probe the interlayer shear thermal deformations and interlayer coupling in phosphorene and hexagonal boron nitride.

New data reveal a sequential mode of alternative polyadenylation. Distal polyA sites are processed first and the resultant transcripts are retained in the nuclear-chromatin matrix for subsequent cleavage and polyadenylation at proximal polyA sites.

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

How the Pacific Walker circulation (PWC) changes under climate change is not well understood. Here, the authors show that the strengthening of the PWC since 1979 is related to internal variability of the Pacific and use this as a constraint to show that it is likely to weaken in the next decades.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

Signal loss in blood oxygen level‐dependent (BOLD) fMRI can lead to misinterpretation of findings. The authors trained a deep learning model to reconstruct compromised BOLD signal in datasets from healthy participants and in patients whose scans suffered signal loss due to intracortical electrodes.

Genomic analysis of neuroblastoma has revealed important disease etiology. In this study, the authors assembled whole genome, exome and transcriptome data from over 700 neuroblastomas and identified molecular signatures correlated with age, and rare, potentially targetable variants overlooked in smaller cohorts.

One consistent challenge in spintronics is electrical control of the magnetisation. Here, You et al demonstrate switching of magnetisation in a heterostucture composed of Mn3SnN and Permalloy, making use of the out-of-plane spin polarization induced by currents in the antiferromagnetic Mn3SnN.

A DNA polymerase editing system offers advantages over prime editing.

A new computational method integrates whole-genome sequencing and transcriptomic data to identify regulatory noncoding variants in an individual cancer genome.

Unique electronmagnetic response of Weyl semimetals have only been reported in static field regime. Here, the authors report evidence of a dynamical chiral anomaly response realized by internal collective lattice deformation with an external static magnetic field in a Weyl semimetal NbAs.

The bandgap of 2D molybdenum disulfide can be tuned uniformly, reproducibly and precisely over a large range by using a glass sphere support and changing the diameter of the spheres.

Pu-erh tea displays cholesterol-lowering properties. Here, Huang et al. show that this is mostly due to the action of a pigment in Pu-erh tea that induces changes in certain gut microbiota and bile acid levels, thus modulating the gut-liver metabolic axis.

Sun et al. demonstrate that the development of bona fide liver cancer can be modelled at structural and molecular levels by introducing c-Myc into directly reprogrammed human hepatocytes with inactivated p53 and RB.

Model biases and internal variability are a cause for uncertainties in climate projections. Here, the authors show that 45% of projected uncertainty in the western Pacific Subtropical High can be reduced by correcting sea surface temperature biases in the equatorial Pacific and beneath marine stratocumulus clouds.

The bandgap of ultrathin black phosphorus can be tuned by a vertical electric field. Here, the authors leverage such electric field to extend the photoresponse of a black phosphorus photodetector to 7.7 μm, opening the doors to various mid-infrared applications.

A major cause of transplanted organ failure is graft arteriosclerosis. Qiuet al. show that a key protease of post-translational SUMO modification, SENP1, is crucial for graft arteriosclerosis by regulating the activity of GATA2 transcription factor in the endothelium, and promoting endothelial inflammation and alloimmunity.