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In liver metastasis of cancer, the inflammatory macrophage niche is dominated by both circulating monocytes and local expansion, but the nature and dynamic of this niche is still unclear. Here the authors use mouse genetic models and lineage-tracing tools to show that, under the condition of monocyte depletion, Kupffer cells pursue epigenetic reprogramming to contribute to this niche.

This study presents the development of nanodrugs based on bacterial-derived outer membrane vesicles for targeted intervention in nerve–cancer crosstalk, which efficiently enhances pancreatic cancer chemotherapy.

RNA methylation has recently identified as an important regulatory mechanism governing functional cellular states, but its effect on the antitumour activity of CD8 ⁺ T cells is not fully explored. Here authors assign an essential nuclear, m⁶A-recognition-dependent function to YTHDF2, which, in conjunction with its regulatory role in IKZF1/3-mediated gene transcription, governs anti-tumor activity in CD8 ⁺ T cells.

In this large-scale exome-wide association study, Deng, Wu, Yang, He et al. report genetic associations of protein-coding variants with neurodegenerative diseases and mental disorders, including for 50 new genes.

Gao et al. identify a piRNA, CHAPIR, that targets the m⁶A methylation of PARP10 and promotes the GSK3β-induced accumulation of nuclear NFATC4, thereby modulating cardiac hypertrophy and heart function upon pressure overload.

Transition metal dichalcogenides represent an exciting class of earth-abundant hydrogen-from-water electrocatalysts, although low efficiencies limit commercialization. Here, authors present a doping strategy to induce a phase transition in cobalt selenide and boost H₂-evolution performance.

Elucidating the nature of topological magnets is at quantum frontier. Here the authors report a topological charge-entropy relation in TbMn₆Sn₆ that goes beyond conventional electron behavior and points to a transport visualization of Chern gapped Dirac fermions.

In this study the authors explore the enigma of GTP-triggered microtubule assembly. The proposed flexible model emphasizes longitudinal and lateral contacts, enhancing our understanding of microtubule nucleation and assembly.

The cryo-electron microscopy structure of the GPR101–Gs complex reveals the mechanism for its constitutive activity and facilitates the screening and identification of GPR101 ligands with rejuvenating potential.

PFKFB3 enhances glycolysis to promote cancer cell proliferation. Here, the authors identify a long noncoding RNA in esophageal squamous cell carcinoma, AGPG, which interacts with PFKFB3 and promotes its stability, leading to increased glycolysis and proliferation.

The off-target effects of any CRISPR-based genome editor are identified with Tracking-seq.

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Iron metabolism dysregulation is associated with various diseases including cancer. Here, the authors show that one iron-triggered lncRNA LncRIM regulates cellular iron metabolism effectively by wiring up the Hippo-YAP  signaling pathway and promotes breast cancer development.

A new contrast technique allows semiconducting and metallic single-walled carbon nanotubes to be imaged separately, offering a way to study their interactions in biological environments.

The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resource for the genetic improvement of wheat.

The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ₄₂, humanin, or formyl peptides offer insight into Aβ₄₂ neurotoxicity, humanin neuroprotection, and FPR ligand selectivity

Scanning tunnelling microscopy is used to reveal a new topological kagome magnet with an intrinsic Chern quantum phase, which shows a distinct Landau fan structure with a large Chern gap.

A new type of Hall effect—the layer Hall effect—is produced in a 2D antiferromagnet that does not exhibit any net magnetization.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

Metal halide perovskite is well-known for the high absorption coefficient; however, its Li-ion transport property remains poorly explored. Here the authors coat an ion conducting metal chloride perovskite interfacial layer on the Li metal anode, enabling good battery performance.

Arabinogalactan RN1 displays potent anti-pancreatic-cancer activity; however, the structure–activity relationship of RN1 is unclear. Now the synthesis of RN1 and a library of glycans are reported, using an iterative preactivation-based one-pot glycosylation strategy. Biological analysis reveals that a decasaccharide is the active structural domain of RN1.

The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL.

The transcription factor RUNX3 plays a key role in the restriction point of cell cycle. Here the authors showed that RUNX3 binds and opens chromatin structure of restriction point associated genes, by sequential recruitment of chromatin remodeling complex, transcription complex and cell cycle regulators.

Here the authors report the development of a topological nonlinear parametric amplification in a dimerized, Su-Schrieffer-Heeger waveguide. Kerr-induced chiral symmetry breaking is demonstrated, showcasing how nonlinearities may control transitions of topological modes to bulk states.

Surface coating is a common method to combat the performance degradation of layered oxide cathodes in rechargeable batteries. Here the authors analyse coating design principles and demonstrate that a lanthurizing coating approach—which alters the atomic structure just beneath the cathode surface—leads to exceptionally high-voltage cycling stability.

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

A LaCl₃-based lithium superionic conductor is developed that has excellent interfacial compatibility with lithium metal electrodes, with its optimized Li_0.388Ta_0.238La_0.475Cl₃ electrolyte exhibiting good Li⁺ conductivity and low activation energy.

A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.

Treg cells can be functionally altered by epigenetic modulators. Here the authors show that the histone H3K36 methyltransferase Setd2 is important for the survival of Treg cells and for the regulation of IL-33 mediated Th2 responses in mice and SETD2 expression is increased in Treg cells from human colorectal cancer tissue.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Layered heterostructures are promising photosensitive materials for advanced optoelectronics. Here, the authors introduce an interfacial coassembly method to construct large-scale perylene/grahene oxide (GO) heterobilayer for broadband photoreception and efficient neuromorphics.

The description of the cryo-EM structure of an orphan adhesion GPCR–G_s protein complex in apo state facilitates the screening and identification of potential ligands of ADGRG2.

Type I PRMT inhibition elicits potent antitumor activity associated with increased interferon response and intron-retained dsRNA accumulation, suggesting its potential combination with immune checkpoint inhibitors for cancer treatment.

A peri-arteriolar niche in the bone marrow for osteogenesis and lymphopoiesis is maintained by mechanical stimulation and is depleted during ageing.