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Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis

Human and mouse experimental models integrated with targeted bile acid metabolomics demonstrate that ursodeoxycholic acid inhibits the occurrence of aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis.

Zhaofeng Zhang
Linfeng Xie
Liangwan Chen
ResearchOpen Access05 Jul 2025
Communications Biology

Volume: 8, P: 1-15

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Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis

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