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Showing 1–2 of 2 results
Advanced filters: Author: Xing-da Li Clear advanced filters

  • Take home Figure. IL-17 promotes the development of heart failure. Upregulation of IL-17 activates NF-κB, which in turn suppresses the expression of CACNA1C encoding the pore-forming subunit of voltage gated Ltype calcium channel Cav1.2 and ATP2A2 encoding SERCA2a. Decreased expression of Cav1.2 and SERCA2a reduced cardiac contractility due to impaired calcium handling and promoted cardiac hypertrophic growth through the activation of calcium related signaling pathway, which eventually led to heart failure. PLN, phospholamban; SERCA2a, sarcoplasmic reticulum Ca2+-ATPase2a; RYR2, ryanodine receptor 2; CAMKII, calcium/calmodulin-dependent kinase II

    • Gen-long Xue
    • De-sheng Li
    • Zhen-wei Pan
    Research
    Acta Pharmacologica Sinica
    Volume: 42, P: 1780-1789

  • An efficient cytosine base editor was developed in cyanobacteria, which allows rapid and precise C → T point mutation and gene inactivation. This genome editing tool will accelerate the metabolic engineering and fundamental researches in cyanobacteria.

    • Xing-Da Li
    • Ling-Mei Liu
    • Weizhong Chen
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-11