Nature Search

Photocatalytic site-selective radical C(sp³)–H aminoalkylation, alkylation and arylation of silanes

Site-selective C–H functionalization of silanes is challenging because of the presence of multiple C–H bonds in the same molecule. Now a general photocatalytic site-selective radical functionalization of organosilicon compounds is reported, enabled by the β-silicon effect, which activates β-C(sp³)–H bonds. These reactions are applicable to linear and complex cyclic silanes.

Xingyi He
Yizhi Zhang
Xiao Shen
Research10 Oct 2024
Nature Synthesis

Volume: 4, P: 188-195
Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers

Transcriptome-wide association studies can uncover genes involved in disease. Here, the authors extend the framework with a transcriptome-wide association study approach which incorporates transcription factor occupancy, adding tissue-specific mechanistic support to associations.

Jingni He
Wanqing Wen
Xingyi Guo
ResearchOpen Access19 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Ladderphane copolymers for high-temperature capacitive energy storage

A class of dielectric copolymers called ladderphanes is shown to outperform existing dielectric polymers and composites, with high discharged energy density and charge–discharge efficiency even at temperatures up to 200 °C.

Jie Chen
Yao Zhou
Qing Wang
Research01 Mar 2023
Nature

Volume: 615, P: 62-66
Large-scale foundation model on single-cell transcriptomics

scFoundation, with 100 million parameters covering about 20,000 genes, pretrained on over 50 million single-cell transcriptomics profiles, is a foundation model for diverse tasks of single-cell analysis.

Minsheng Hao
Jing Gong
Le Song
Research06 Jun 2024
Nature Methods

Volume: 21, P: 1481-1491
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

Lang Wu
Wei Shi
Wei Zheng
Research18 Jun 2018
Nature Genetics

Volume: 50, P: 968-978
Gold nanocrystals with DNA-directed morphologies

Bottom-up synthesis of colloidal metallic nanomaterials with a designable structure is challenging. Here, the authors report the directed crystallisation of gold by a single DNA molecular regulator, using it to synthesise gold nanocrystals with defined complex morphologies.

Xingyi Ma
June Huh
Sang Jun Sim
ResearchOpen Access16 Sept 2016
Nature Communications

Volume: 7, P: 1-8
Complex Network Clustering by a Multi-objective Evolutionary Algorithm Based on Decomposition and Membrane Structure

Ying Ju
Songming Zhang
Xingyi Zhang
ResearchOpen Access27 Sept 2016
Scientific Reports

Volume: 6, P: 1-13
Single-neuron representation of learned complex sounds in the auditory cortex

Using a combination of two-photon imaging and single-cell electrophysiology, the authors discover that associative learning induces the emergence of a unique subset of neurons in the auditory cortex, exhibiting high-rate bursting responses to the learned complex sounds but not to any of the constituents.

Meng Wang
Xiang Liao
Xiaowei Chen
ResearchOpen Access31 Aug 2020
Nature Communications

Volume: 11, P: 1-14
Probing of the internal damage morphology in multilayered high-temperature superconducting wires

Damage that occurs in second generation high-temperature-superconducting wires is problematic. Here, the authors present real-time magnetic flux behaviour in these wires under tensile strain and reveal damage evolution, including the amorphous phase in the superconducting layer acting in crack blunting during tension

You-He Zhou
Cong Liu
Xingyi Zhang
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-8
Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004–2014

Li Zhang
Na Zhao
Shelan Liu
ResearchOpen Access23 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
Genetic analysis of 19 X chromosome STR loci for forensic purposes in four Chinese ethnic groups

Xingyi Yang
Xiaofang Zhang
Chao Liu
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Wanqing Wen
Norihiro Kato
Xiao-Ou Shu
ResearchOpen Access20 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism

Mengwen Zhang
Xingyi Pan
Lei Zheng
ResearchOpen Access29 Oct 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-18
Comprehensive analysis of lipid metabolic signatures identified CEBPD promotes breast cancer cell proliferation

Yu Zhao
Huan He
Linna Yu
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes

Xingyi Li
Wei Wang
Xiulan Zhang
ResearchOpen Access01 Mar 2018
Eye

Volume: 32, P: 1174-1182
Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

Fei Li
Diping Song
Daniel S. W. Ting
ResearchOpen Access22 Sept 2020
npj Digital Medicine

Volume: 3, P: 1-8
Long intergenic non-coding RNA expression signature in human breast cancer

Yanfeng Zhang
Erin K. Wagner
Jirong Long
ResearchOpen Access29 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Fruit economic characteristics and yields of 40 superior Camellia oleifera Abel plants in the low-hot valley area of Guizhou Province, China

Lu Yang
Chao Gao
Chaoyi Deng
ResearchOpen Access29 Apr 2022
Scientific Reports

Volume: 12, P: 1-16
Study on roof movement law of local filling mining under peak cluster landform

Hengyu Su
Chang Luo
Ziyi Wang
ResearchOpen Access07 Sept 2023
Scientific Reports

Volume: 13, P: 1-15
Comparative genomics reveals insights into genetic variability and molecular evolution among sugarcane yellow leaf virus populations

Jia-Ju Lu
Er-Qi He
San-Ji Gao
ResearchOpen Access30 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Author Correction: Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

Fei Li
Diping Song
Daniel S. W. Ting
Amendments and CorrectionsOpen Access22 Mar 2022
npj Digital Medicine

Volume: 5, P: 1
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

Xingyi Chen
Chaoran Shi
Xiaobo Xia
ReviewsOpen Access15 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-40

Search

Photocatalytic site-selective radical C(sp³)–H aminoalkylation, alkylation and arylation of silanes

Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers

Ladderphane copolymers for high-temperature capacitive energy storage

Large-scale foundation model on single-cell transcriptomics

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Gold nanocrystals with DNA-directed morphologies

Complex Network Clustering by a Multi-objective Evolutionary Algorithm Based on Decomposition and Membrane Structure

Single-neuron representation of learned complex sounds in the auditory cortex

Probing of the internal damage morphology in multilayered high-temperature superconducting wires

Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004–2014

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Genetic analysis of 19 X chromosome STR loci for forensic purposes in four Chinese ethnic groups

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism

Comprehensive analysis of lipid metabolic signatures identified CEBPD promotes breast cancer cell proliferation

Difference of uveal parameters between the acute primary angle closure eyes and the fellow eyes

Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

Long intergenic non-coding RNA expression signature in human breast cancer

Fruit economic characteristics and yields of 40 superior Camellia oleifera Abel plants in the low-hot valley area of Guizhou Province, China

Study on roof movement law of local filling mining under peak cluster landform

Comparative genomics reveals insights into genetic variability and molecular evolution among sugarcane yellow leaf virus populations

Author Correction: Development and clinical deployment of a smartphone-based visual field deep learning system for glaucoma detection

Endoplasmic reticulum stress: molecular mechanism and therapeutic targets

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