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scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data

Here the authors propose a deep learning model that integrates multi-condition, multi-batch single-cell RNA-sequencing datasets. The model disentangles biological variation (condition effect) from technical confounders (batch effect) and overcomes some limitations of existing approaches.

Ziqi Zhang
Xinye Zhao
Xiuwei Zhang
ResearchOpen Access30 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Long-term exposure to ambient PM2.5, particulate constituents and hospital admissions from non-respiratory infection

The study evaluated the impact of PM2.5 and its constituents on hospital admissions from non-respiratory infection. Here, the authors showed that nonrespiratory infections are an under-appreciated health effect of PM2.5 while Sulfates contributed the largest weights in the observed associations

Yijing Feng
Edgar Castro
Joel Schwartz
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-9
The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Jumonji domain-containing histone demethylases regulate flowering in plants. Here Zheng et al. show that Arabidopsis JMJ13 is an H3K27me3 demethylase that recognizes H3K27me3 via hydrogen bonding and hydrophobic interactions and affects both photoperiod and temperature-dependent flowering responses.

Shuzhi Zheng
Hongmiao Hu
Jiamu Du
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-11
Iron-responsive ZNF185 overexpression drives mitochondrial fission and endoplasmic reticulum stress via cytoskeletal remodeling in granulosa cells

Zhaoyue Huang
Yang You
Qingxue Zhang
ResearchOpen Access28 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-11
Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer

Xinye Wang
Ting Qiu
Ceshi Chen
Research10 May 2021
Cell Death & Differentiation

Volume: 28, P: 2931-2945
Multiple objectives escaping bird search optimization and its application in stock market prediction based on transformer model

Dedai Wei
Zimo Wang
Kaichen Ouyang
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-51
Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study

Andrea L. Roberts
Xinye Qiu
Marc G. Weisskopf
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-10

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scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data

Long-term exposure to ambient PM2.5, particulate constituents and hospital admissions from non-respiratory infection

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Iron-responsive ZNF185 overexpression drives mitochondrial fission and endoplasmic reticulum stress via cytoskeletal remodeling in granulosa cells

Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer

Multiple objectives escaping bird search optimization and its application in stock market prediction based on transformer model

Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study

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