Nature Search

Exploring new applications of toasted chestnut shells as an oak alternative in distilled spirit aging

Yue Zhao
Xinyi Lu
Lijun Song
ResearchOpen Access16 Jan 2026
npj Science of Food

Volume: 10, P: 1-12
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Author Correction: Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience

Ruikai Chai
Nawen Wang
Weisheng Wang
Amendments and CorrectionsOpen Access18 Sept 2025
Nature Communications

Volume: 16, P: 1
A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

This study reveals that E. coli lipoate-protein ligase A (LplA) exhibits reversible phase separation and forms condensates in cells, which can be specifically regulated by small molecules, offering chemical tools for synthetic biology and biomedicine.

Jinglei Nie
Xinyi Zhang
An-Ping Zeng
ResearchOpen Access12 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Hepatic HMGCS2-derived β-hydroxybutyrate attenuates hippocampal insulin resistance and neuroinflammation to promote MASLD-induced cognitive function

Fatty liver disease may harm the brain by starving it of a protective fuel. This study shows that restoring this fuel, BHB, can rescue memory and brain health, revealing a direct liver-brain link and a promising treatment target.

Lijuan Nie
Jing Sun
Xiqiao Zhou
ResearchOpen Access10 Jan 2026
Communications Biology

Volume: 9, P: 1-13
Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience

Neural mechanisms underlying strengthening of escape behaviors are not fully understood. Here authors show that mPFC (medial prefrontal cortex)/VTg (ventral tegmental nucleus of gudden) to cholecystokinin expressing neurons in PMd (dorsal premammillary nucleus) neural pathway controls the threat memory-driven strengthening of escape. Furthermore, authors demonstrate a heterosynaptic role of eCB (endocannabinoid) signaling as the underlying molecular mechanism.

Ruikai Chai
Nawen Wang
Weisheng Wang
ResearchOpen Access27 May 2025
Nature Communications

Volume: 16, P: 1-16
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
The role of Npt1 in regulating antifungal protein activity in filamentous fungi

Antifungal proteins (AFPs) produced by filamentous ascomycetes are effective against fungal infection e.g., Aspergillus flavus that can cause aspergillosis on corn and peanut and aflatoxin production. Here, the author report two AFPs and their interacting protein Ntp1 in mediating fungal growth, toxin synthesis and pathogenicity.

Yu Wang
Sen Wang
Shihua Wang
ResearchOpen Access23 Mar 2025
Nature Communications

Volume: 16, P: 1-20
Detecting global and local hierarchical structures in cell-cell communication using CrossChat

Cell-cell communication (CCC) plays a critical role in biological processes across different scales. Here, authors develop CrossChat, a computational framework that identifies and analyses hierarchical CCC structures using single-cell RNA-seq and spatial transcriptomics data, offering insights into complex tissue functions.

Xinyi Wang
Axel A. Almet
Qing Nie
ResearchOpen Access03 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury

Renal tubular epithelial cells (TECs) can initiate an adaptive or maladaptive response after injuries of different severity. Here, the authors elucidate a chromatin-mediated mechanism underlying the responses of TECs to varying kidney injuries.

Xinyi Cao
Jiuchen Wang
Lirong Zhang
ResearchOpen Access28 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Cloud behaviour on tidally locked rocky planets from global high-resolution modelling

A high-resolution global climate simulation of tidally locked rocky planets orbiting around M dwarfs with explicit convection resolves the behaviour of their clouds, determining the cloud properties and suggesting the frequent appearance of cloud streets affecting the planetary energy balance.

Jun Yang
Yixiao Zhang
Zhihong Tan
Research19 Jun 2023
Nature Astronomy

Volume: 7, P: 1070-1080
LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation

Meng Li
Xiuying Kui
Xia Cao
ResearchOpen Access06 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-9
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

Bai Cui
Huandong Luo
Fei Peng
ResearchOpen Access05 Mar 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-19
Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

Qian Wang
Lulingxiao Nie
Qi Wang
ResearchOpen Access24 Mar 2021
International Journal of Oral Science

Volume: 13, P: 1-10
Ostarine attenuates pyocyanin in Pseudomonas aeruginosa by interfering with quorum sensing systems

Limin Dong
Lang Sun
Xuefu You
Research03 Sept 2021
The Journal of Antibiotics

Volume: 74, P: 863-873
Integrative analyses reveal transcriptome-proteome correlation in biological pathways and secondary metabolism clusters in A. flavus in response to temperature

Youhuang Bai
Sen Wang
Shihua Wang
ResearchOpen Access29 Sept 2015
Scientific Reports

Volume: 5, P: 1-13
The DmtA methyltransferase contributes to Aspergillus flavus conidiation, sclerotial production, aflatoxin biosynthesis and virulence

Kunlong Yang
Linlin Liang
Shihua Wang
ResearchOpen Access16 Mar 2016
Scientific Reports

Volume: 6, P: 1-13

Search

Exploring new applications of toasted chestnut shells as an oak alternative in distilled spirit aging

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

Author Correction: Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Hepatic HMGCS2-derived β-hydroxybutyrate attenuates hippocampal insulin resistance and neuroinflammation to promote MASLD-induced cognitive function

Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience

Diminishing benefits of urban living for children and adolescents’ growth and development

The role of Npt1 in regulating antifungal protein activity in filamentous fungi

Detecting global and local hierarchical structures in cell-cell communication using CrossChat

Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Cloud behaviour on tidally locked rocky planets from global high-resolution modelling

LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation

Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging

Ostarine attenuates pyocyanin in Pseudomonas aeruginosa by interfering with quorum sensing systems

Integrative analyses reveal transcriptome-proteome correlation in biological pathways and secondary metabolism clusters in A. flavus in response to temperature

The DmtA methyltransferase contributes to Aspergillus flavus conidiation, sclerotial production, aflatoxin biosynthesis and virulence

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