Nature Search

Electrostatic-repulsion-based transfer of van der Waals materials

An electrostatic-repulsion-enabled advanced transfer technique based on ammonia solution is introduced for separating van der Waals thin-film materials from their substrates, demonstrating suitability for its use in the complementary metal–oxide–semiconductor (CMOS) industry.

Xudong Zheng
Jiangtao Wang
Jing Kong
Research24 Sept 2025
Nature

Volume: 645, P: 906-914
Bi-terminal fusion of intrinsically-disordered mussel foot protein fragments boosts mechanical strength for protein fibers

High-yield production of well-performing protein materials is challenging due to their high molecular weights and repetitive sequences. Here the authors develop a method to boost the strength of low molecular-weight protein materials by bi-terminal fusion of intrinsically-disordered mussel foot protein fragments, while achieving high yield.

Jingyao Li
Bojing Jiang
Fuzhong Zhang
ResearchOpen Access14 Apr 2023
Nature Communications

Volume: 14, P: 1-12
Digitally enhanced Raman spectroscopy

In this Tools of the Trade article, Xinyuan Bi describes the development of digital colloid-enhanced Raman spectroscopy (dCERS), a method that addresses the reproducibility issues of surface-enhanced Raman spectroscopy (SERS) at ultra-low concentrations by using single-molecule counting.

Xinyuan Bi
Research Highlights12 May 2025
Nature Reviews Cancer

Volume: 25, P: 569
The FTR dual-loop architecture based on SID–NLMS can achieve a threshold of 0.0001°/s and an ARW of 0.006°/√h for MEMS QMG

Zhuolin Yu
Tong Zhou
Yan Su
ResearchOpen Access19 Aug 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-10
Photocatalytic labelling-enabled subcellular-resolved RNA profiling and synchronous multi-omics investigation

Profiling subcellular multi-omics with spatiotemporal resolution remains a key challenge in cell biology. Now an orthogonal photocatalytic labelling strategy has been developed that enables simultaneous, non-genetic profiling of mitochondrial RNA and proteins within the same sample, providing a chemical approach for transcriptomic and proteomic analyses with spatial and temporal precision.

Yunpeng Bi
Lishan Yu
Xinyuan Fan
Research16 Sept 2025
Nature Chemistry

P: 1-12
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Deep spectral component filtering as a foundation model for spectral analysis demonstrated in metabolic profiling

Xue et al. develop a foundation model for spectral analysis. It excels in multiple tasks, such as denoising spectra and quantifying trace molecules, and is especially promising in identifying metabolic biomarkers of diseases such as stroke, Alzheimer’s disease and prostate cancer.

Bingsen Xue
Xinyuan Bi
Cheng Jin
Research23 May 2025
Nature Machine Intelligence

Volume: 7, P: 743-757
Digital colloid-enhanced Raman spectroscopy by single-molecule counting

Research published in Nature shows that surface-enhanced Raman spectroscopy carried out with colloids can quantify a range of molecules down to concentrations at the femtomolar level.

Xinyuan Bi
Daniel M. Czajkowsky
Jian Ye
Research17 Apr 2024
Nature

Volume: 628, P: 771-775
Heteroepitaxial passivation of Cs₂AgBiBr₆ wafers with suppressed ionic migration for X-ray imaging

Ionic migration degrades not only the characteristics of halide perovskite solar cells, but also those of perovskite X-ray detectors. Here Yang et al. employ heteroepitaxial BiOBr to passivate Cs₂AgBiBr₆ double perovskite, which suppresses ionic migration and obtain high performance X-ray detectors.

Bo Yang
Weicheng Pan
Jiang Tang
ResearchOpen Access30 Apr 2019
Nature Communications

Volume: 10, P: 1-10
Circular polarized light-dependent anomalous photovoltaic effect from achiral hybrid perovskites

The manipulation of anomalous photovoltaic current by changing the light helicity has attracted an increasing interest in the field. Here, the authors realize circular polarized light-dependent anomalous bulk photovoltaic effect in achiral hybrid perovskites with a large asymmetry factor of 0.24.

Tingting Zhu
Jie Bie
Junhua Luo
ResearchOpen Access13 Dec 2022
Nature Communications

Volume: 13, P: 1-8
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Genomic variation in 3,010 diverse accessions of Asian cultivated rice

Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic location and patterns of introgression consistent with multiple rice domestication events.

Wensheng Wang
Ramil Mauleon
Hei Leung
ResearchOpen Access25 Apr 2018
Nature

Volume: 557, P: 43-49
A multicenter, hospital-based and non-inferiority study for diagnostic efficacy of automated whole breast ultrasound for breast cancer in China

Yujing Xin
Xinyuan Zhang
Youlin Qiao
ResearchOpen Access06 Jul 2021
Scientific Reports

Volume: 11, P: 1-9
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Serine hydroxymethyltransferase 2 (SHMT2) converts serine to glycine in mitochondria and is upregulated in a variety of cancers. Here the authors show that acetylation of the lysine-95 (K95) residue negatively regulates SHMT2 expression and activity and is deacetylated by SIRT3 in colorectal cancer.

Zhen Wei
Jinglue Song
Wei Yu
ResearchOpen Access26 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells

Jiawei Shao
Shichao Li
Mingqi Xie
ResearchOpen Access04 Jan 2024
Cell Research

Volume: 34, P: 31-46
A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent

Weiguo Zou
Chunxia Luo
Xinyuan Liu
Research15 Jan 2004
Oncogene

Volume: 23, P: 457-464
A second generation human haplotype map of over 3.1 million SNPs

A consortium reports the tripling of the number of genetic markers in Phase II of the International HapMap Project. This map of human genetic variation will continue to revolutionize discovery of susceptibility loci in common genetic diseases, and study of genes under selection in humans.

Kelly A. Frazer (Principal Investigator)
Dennis G. Ballinger
John Stewart
Research18 Oct 2007
Nature

Volume: 449, P: 851-861
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

Xingyou Wan
Chao Wang
Wei Yu
ResearchOpen Access06 Aug 2020
Cell Death & Disease

Volume: 11, P: 1-16
Charge order and broken rotational symmetry in magic-angle twisted bilayer graphene

When scanning tunnelling spectroscopy is used to map the electronic structure of magic-angle twisted bilayer graphene, a pseudogap phase is found, accompanied by a global charge-ordered stripe phase.

Yuhang Jiang
Xinyuan Lai
Eva Y. Andrei
Research31 Jul 2019
Nature

Volume: 573, P: 91-95
Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations

Raft-Seq is a generalizable pooled screening platform that combines high-content imaging, machine learning and microraft isolation, and enables efficient screening of genetic perturbations based on their impact on phenotypes.

Alex L. Yenkin
John C. Bramley
William J. Buchser
ResearchOpen Access25 Oct 2022
Communications Biology

Volume: 5, P: 1-14
Purification and characterization of a novel phloretin-2′-O-glycosyltransferase favoring phloridzin biosynthesis

Tingjing Zhang
Jianqiang Liang
Mingtao Fan
ResearchOpen Access12 Oct 2016
Scientific Reports

Volume: 6, P: 1-15
Genome-wide detection and characterization of positive selection in human populations

Sabeti et al. build on their This paper builds on previous work of detecting selection on human genes, using the many more markers available in the Phase II HapMap project. Three examples of apparent population-specific selection based on geographic area are described, and how these may relate to human biology is discussed.

Pardis C. Sabeti
Patrick Varilly
John Stewart
Research18 Oct 2007
Nature

Volume: 449, P: 913-918
LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis

Mo Liu
Qingwen Liu
Jinsong Li
ResearchOpen Access01 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-16
The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation

Honghong Sun
Mei Lin
Youhai H. Chen
ResearchOpen Access20 Apr 2020
Scientific Reports

Volume: 10, P: 1-13
Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma

L Liu
W Li
C Qian
Research09 Feb 2012
Gene Therapy

Volume: 20, P: 84-92
Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma

Zhen-long Ye
Yao Huang
Qi-jun Qian
Research04 May 2015
Acta Pharmacologica Sinica

Volume: 36, P: 1237-1245
Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene

X Cao
M Yang
X-Y Liu
Research17 Mar 2011
Gene Therapy

Volume: 18, P: 765-777
The International HapMap Project

Richard A. Gibbs
John W. Belmont
Toshihiro Tanaka
Special Features18 Dec 2003
Nature

Volume: 426, P: 789-796
Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy

Qi Zhang
Guihua Chen
Qijun Qian
Reviews23 Jan 2007
Cell Research

Volume: 17, P: 89-99
Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression

K-J Zhang
J Zhang
X-Y Liu
Research13 Jul 2012
Cancer Gene Therapy

Volume: 19, P: 619-629

Search

Electrostatic-repulsion-based transfer of van der Waals materials

Bi-terminal fusion of intrinsically-disordered mussel foot protein fragments boosts mechanical strength for protein fibers

Digitally enhanced Raman spectroscopy

The FTR dual-loop architecture based on SID–NLMS can achieve a threshold of 0.0001°/s and an ARW of 0.006°/√h for MEMS QMG

Photocatalytic labelling-enabled subcellular-resolved RNA profiling and synchronous multi-omics investigation

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

Deep spectral component filtering as a foundation model for spectral analysis demonstrated in metabolic profiling

Digital colloid-enhanced Raman spectroscopy by single-molecule counting

Heteroepitaxial passivation of Cs₂AgBiBr₆ wafers with suppressed ionic migration for X-ray imaging

Circular polarized light-dependent anomalous photovoltaic effect from achiral hybrid perovskites

A saturated map of common genetic variants associated with human height

Genomic variation in 3,010 diverse accessions of Asian cultivated rice

A multicenter, hospital-based and non-inferiority study for diagnostic efficacy of automated whole breast ultrasound for breast cancer in China

Human lifespan changes in the brain’s functional connectome

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells

A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent

A second generation human haplotype map of over 3.1 million SNPs

Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

Charge order and broken rotational symmetry in magic-angle twisted bilayer graphene

Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations

Purification and characterization of a novel phloretin-2′-O-glycosyltransferase favoring phloridzin biosynthesis

Genome-wide detection and characterization of positive selection in human populations

LncRNA LTSCCAT promotes tongue squamous cell carcinoma metastasis via targeting the miR-103a-2-5p/SMYD3/TWIST1 axis

The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation

Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma

Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma

Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene

The International HapMap Project

Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy

Complete eradication of hepatomas using an oncolytic adenovirus containing AFP promoter controlling E1A and an E1B deletion to drive IL-24 expression

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