Tryptophan is often found on the surface of membrane-associated proteins that interact with the lipid membrane, however, the exact role of each tryptophan residue remains unknown. Here, the authors use racemic protein crystallography to probe dedicated tryptophan interactions of a model bacteriocin aureocin A53 with tetrahedral anions mimicking the head group of phospholipids.
- Alexander J. Lander
- Laura Domínguez Mercado
- Louis Y. P. Luk
