Tumor suppressor PTEN negatively regulates PI3K-AKT signaling by dephosphorylating PIP3. PTEN can also dephosphorylate peptide substrates in vitro, but the physiological relevance of this activity was unclear. Jiang and colleagues show that PTEN is a protein tyrosine phosphatase that selectively dephosphorylates insulin receptor substrate-1 and thus regulates cell metabolism and growth.
- Yuji Shi
- Junru Wang
- Xuejun Jiang
