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The Antarctic Circumpolar Current (ACC) since the Last Interglacial is reconstructed, showing orbital-scale shifts in ACC position driven by eccentricity and precession, possibly counteracting the predicted southward shift due to global warming.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

A microchip-based DNA synthesis method enables scalable production of complex DNA constructs.

Multiple resonance (MR) emitters with narrowband luminescence typically suffer from inadequate frontier molecular orbital levels. Here, authors incorporate cyano motifs at peripheral sites of the MR backbone to adjust the energy levels, realizing device efficiency of over 23% for stable devices.

This research highlights the role of a KNOX1 transcription factor in stalling receptacle growth in cucumber, leading to bisexual flowers with superior ovaries like those in tomatoes. These insights enhance our understanding of ovary formation and sex in cucurbits.

Methods for constructing targeted synthetic communities using existing microbial resources remain limited. Here, the authors report a genome-scale metabolic model-integrated strategy for bottom-up construction of synthetic microbial communities in the plant rhizosphere.

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driving excitatory–inhibitory imbalance and neuronal hyperexcitability in epilepsy.

Brassica oleracea is plant species comprising economically important vegetable crops. Here, the authors report the draft genome sequence of B. oleracea and, through a comparative analysis with the closely related B. rapa, reveal insights into Brassicaevolution and divergence of interspecific genomes and intraspecific subgenomes.

Seawater electrolysis at ampere-level current densities demands durable anodes for practical hydrogen production. Here, the authors report that a single non-oxygen anion enables dual modulation of surface and interlayer structures, stabilizing layered double hydroxide anodes for over 5,000 hours.

Ruddlesden popper layered perovskites can be used in optoelectronic devices, but the understanding of their lattice strain as well as ferroelasticity is still lacking. Here, the authors find ferroelasticity in layered perovskites with layer number more than one and reveal its mechanism.

The adaptation to atomically thin 2D semiconductors and van der Waals layered ferroelectrics can enable negative capacitance transistors with superior performance and bendability. Here, the authors report flexible negative capacitance transistors based on MoS2 and a ferroelectric dielectric CIPS with a minimum sub-threshold slope of 28 mV/dec and high gain logic invertors.

Although most patients achieve complete response after standard-of-care treatment, residual disease in patients with nasopharyngeal carcinoma is associated with poor prognosis. Here the authors report the results of a phase 2 trial of toripalimab (anti-PD1) plus capecitabine for patients with residual nasopharyngeal carcinoma.

Thin films of halide perovskites are promising for solar cell technology but they do not perform well at the band edge due to the low optical absorption. Herein, Chen et al. fabricate a high efficiency single crystal perovskite solar cell with thicker single crystals to harvest the below-bandgap photons.

A biosafety time bomb may be looming as unapproved varieties of pest-resistant transgenic rice have edged beyond the remit of field trials.

Conductive organic fibres can be tethered to biological surfaces without impeding biological features.

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

Utilizing the immense osmotic energy in membrane separation processes enables spontaneous lithium extraction while generating net energy, offering a promising method for carbon-negative resource recovery.

A Stereo-seq and scRNA-seq atlas of mouse liver in homeostasis and regeneration after partial hepatectomy identifies zonated genes, pathways, cell–cell interactions and gene regulatory networks. Functional validation finds that cooperation between TBL1XR1 and β-catenin activates hepatocyte proliferation.

China’s low-altitude aviation economy is poised to become a trillion-yuan industry in 2025 — if safety and security challenges can be overcome.

Radiative cooling is a sustainable subambient cooling technology. Here, authors show a scalable and practical design of a dual-selective thermal emitter that is shown to have enhanced radiative cooling potential over existing typical designs.

Ultrathin films of gallium oxide with a dielectric constant of around 30 can be formed on the surface of molybdenum disulfide using a liquid metal-based approach and used as the gate insulator in transistors.

Adipose tissue fibrosis is connected to obesity-related metabolic dysfunction. Qiu and colleagues discover that the Hippo pathway acts as a molecular switch in the initiation and development of adipose tissue fibrosis upon TGFβ stimulation.

The study assembled a chromosome-level genome of Cycas panzhihuaensis, the last major lineage of seed plants for which a high-quality genome assembly was lacking. The study closes an important gap in our understanding of genome structure and evolution in seed plants.

Here the authors characterize a monoclonal antibody from a COVID-19 convalescent patient that interferes with SARS-CoV-2 spike binding to ACE2 and has prophylactic and therapeutic activity in non-human primates. Antibody-dependent enhancement of infection is prevented by mutating the Fc region of the antibody.

Ulcerative colitis is associated with increased infiltration and cellularity, yet the precise tissue topology remains poorly understood. Here the authors employ imaging mass cytometry and single-cell RNA sequencing to characterise intestinal lesions in patients with ulcerative colitis, and show the architecture at the individual cell level which includes a decrease in the resident macrophage population.

Buildings account for a large proportion of the global energy consumption. Here the electrochromic smart window realizes year-round energy savings by managing visible, near-infrared and mid-infrared light.

Neovaginas are surgically constructed to correct uterovaginal agenesis in women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Here, in a longitudinal study, the authors characterize the dynamics of neovaginal microbiota assembly, showing resemblance to normal vaginal flora at 6-12 months post-surgery, albeit with a bacterial vaginosis-like structure, and further developed into a structure resembling that of the homeostatic pre-surgery dimple microbiota by 2-4 years post-surgery.

Pei et al. show that rhythmic redox signalling controls CLOCK through endogenous H₂O₂ oscillations via reversible oxidative modifications, and that p66^Shc modulates the rhythm of H₂O₂ levels.

The molecular mechanisms determining the response to radiotherapy remain incompletely understood. Here, the authors demonstrate that the E3 ubiquitin ligase and intracellular Fc receptor, TRIM21, impairs CD8⁺ T cell responses in nasopharyngeal carcinoma tumour models following ionizing radiation.

Despite advances in cancer therapy, the persistent challenge of treatment resistance and particularly multidrug resistance remains a substantial barrier to further improvements in patient outcomes. In this Review, the authors discuss preclinical and clinical advances in understanding multidrug resistance, with an emphasis on resistance to chemotherapies and targeted therapies, as well as the progress made in translating these findings into novel strategies to overcome this challenge and thus improve patient outcomes.

Legumes develop root nodules to access nitrogen. A spatial transcriptomic analysis of Lotus japonicus uncovered key molecular mechanisms and genes involved in nodule development, promoting the creation of novel nitrogen-fixing crops.

The early signalling events following ethylene perception by plants remain incompletely understood. Here the authors show that in the absence of ethylene, rice MHZ3, a known stabilizer of OsEIN2, promotes phosphorylation of OsCTR2 to suppress ethylene signalling.