Nature Search

Mechanism of capsaicin entry into buried vanilloid sites in TRPV1

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

Meng-Yang Sun
Yu-Jing Bian
Ye Yu
Research23 Jul 2025
Nature Chemical Biology

P: 1-13
CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

Only a limited proportion of patients with non-small cell lung cancer respond to anti-PD-1/PD-L1 immunotherapy. Here, the authors show that in autochthonous models of KRAS-mutated lung cancer, CCL7 promotes cDC1 infiltration into the lungs, sustaining antitumor immune responses and potentiating anti-PD1 treatment efficacy.

Man Zhang
Wei Yang
Bo Zhong
ResearchOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1-17
Autophagosomes coated in situ with nanodots act as personalized cancer vaccines

Cancer vaccine is a powerful cancer immunotherapy strategy. Here autophagosomes coated with nanodots in situ in tumours serve as personalized cancer vaccines, effectively activating anti-cancer immune responses in vivo.

Wei-Qiang Huang
Wei You
Ye-Zi You
Research03 Jan 2025
Nature Nanotechnology

Volume: 20, P: 451-462
Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction

Ya-Qi Zhang
Qing Zhang
Shi-Wu Li
ResearchOpen Access17 May 2025
Molecular Psychiatry

Volume: 30, P: 4627-4640
Tuning the Chern number in quantum anomalous Hall insulators

The number of edge channels in quantum anomalous Hall insulators is controlled by varying either the magnetic dopant concentration or the interior spacer layer thickness, yielding Chern numbers up to 5.

Yi-Fan Zhao
Ruoxi Zhang
Cui-Zu Chang
Research16 Dec 2020
Nature

Volume: 588, P: 419-423
Atoh1 mediated disturbance of neuronal maturation by perinatal hypoxia induces cognitive deficits

Atoh1 hinders neuronal dendritic branching, cell migration and long-term cognitive functions by modulating Kif21b to disrupt microtubule’s dynamic stability under perinatal chronic hypoxia.

Xin-yu Cai
Si-yu Ma
Xu-ming Mo
ResearchOpen Access11 Sept 2024
Communications Biology

Volume: 7, P: 1-14
WSTF acetylation by MOF promotes WSTF activities and oncogenic functions

Yan Liu
Yuan-Yue Zhang
Xiao-Jun Zhang
Research09 Jun 2020
Oncogene

Volume: 39, P: 5056-5067
Small extracellular vesicles derived from human MSCs prevent allergic airway inflammation via immunomodulation on pulmonary macrophages

Shu-Bin Fang
Hong-Yu Zhang
Qing-Ling Fu
ResearchOpen Access01 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-15
Mandarin fish (Sinipercidae) genomes provide insights into innate predatory feeding

He, Li, and Lv et al. took a genomics approach to study innate feeding behavior in mandarin fish. They identify genes related to predatory feeding that underwent rapid adaptive evolution. They also functionally validate the role of bmp4-edar pathway in inducing predatory feeding in zebrafish.

Shan He
Ling Li
Xu-Fang Liang
ResearchOpen Access09 Jul 2020
Communications Biology

Volume: 3, P: 1-13
Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice

Cui-Zhu Yang
Shu-Han Wang
Yu-Xin Ma
ResearchOpen Access21 Jan 2023
Cell Death Discovery

Volume: 9, P: 1-13
Quantitative analysis, pharmacokinetics and metabolomics study for the comprehensive characterization of the salt-processing mechanism of Psoraleae Fructus

Kai Li
Ning Zhou
Ya-Qi Lu
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-10
Construction of China national newborn growth standards based on a large low-risk sample

Xin-Nan Zong
Hui Li
Shao-Jie Yue
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

Jin-Feng Xiang
Wen-Quan Wang
Xian-Jun Yu
ResearchOpen Access12 Jan 2016
Scientific Reports

Volume: 6, P: 1-13
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy

Qing Li
Shan Geng
Bo Xu
ReviewsOpen Access07 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-48

Search

Mechanism of capsaicin entry into buried vanilloid sites in TRPV1

CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

Autophagosomes coated in situ with nanodots act as personalized cancer vaccines

Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction

Tuning the Chern number in quantum anomalous Hall insulators

Atoh1 mediated disturbance of neuronal maturation by perinatal hypoxia induces cognitive deficits

WSTF acetylation by MOF promotes WSTF activities and oncogenic functions

Small extracellular vesicles derived from human MSCs prevent allergic airway inflammation via immunomodulation on pulmonary macrophages

Mandarin fish (Sinipercidae) genomes provide insights into innate predatory feeding

Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice

Quantitative analysis, pharmacokinetics and metabolomics study for the comprehensive characterization of the salt-processing mechanism of Psoraleae Fructus

Construction of China national newborn growth standards based on a large low-risk sample

Mutant p53 determines pancreatic cancer poor prognosis to pancreatectomy through upregulation of cavin-1 in patients with preoperative serum CA19-9 ≥ 1,000 U/mL

Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy

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