Nature Search

Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

The efficient construction of trifluoromethylated alkanes bearing a CF₃ chiral center is of great importance in organic synthesis. Here, the authors disclose the enantioselective syntheses of α-trifluoromethylated allylic alkanes via reductive trifluoroalkylation.

Ruo-Xing Jin
Bing-Bing Wu
Xi-Sheng Wang
ResearchOpen Access17 Nov 2022
Nature Communications

Volume: 13, P: 1-8
Tunning valence state of cobalt centers in Cu/Co-CoO_1-x for significantly boosting water-gas shift reaction

Constructing catalysts with dual active sites is crucial for optimizing adsorption sites and enhancing catalytic performance. Here, uniformly dispersed CuCo alloy and CoO nanosheet composite catalysts with dual active sites were developed, significantly boosting activity in the water-gas shift reaction.

Xing-Chi Li
Jun-Hao Wang
Ya-Wen Zhang
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Integrated transcriptional and biochemical profiling suggests mechanisms associated with rapid cold hardening in adult Liriomyza trifolii (Burgess)

Xiao-Xiang Zhang
Junaid Iqbal
Yu-Zhou Du
ResearchOpen Access14 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Publisher Correction: Promoting nitrogen electroreduction to ammonia with bismuth nanocrystals and potassium cations in water

Yu-Chen Hao
Yu Guo
Chun-Hua Yan
Amendments and Corrections08 Mar 2019
Nature Catalysis

Volume: 2, P: 467
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

Model systems to study SARS-CoV-2 infection are required to better understand the immune response. Here the authors use a lung and macrophage co-culture system by differentiation of human pluripotent stem cells to better understand the phenotype and gene expression changes in host lung cells and macrophages after SARS-CoV-2 infection in vitro.

Qizhou Lian
Kui Zhang
Huanhuan Joyce Chen
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-14
Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate

Nucleotide second messengers are employed by many bacterial species to regulate various cellular processes. Here, the authors demonstrate that 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) controls the important biological functions and virulence in Ralstonia solanacearum by abolishing the interaction between a transcriptional regulator and the promoters of target genes.

Xia Li
Wenfang Yin
Yinyue Deng
ResearchOpen Access23 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Probing the atomically diffuse interfaces in Pd@Pt core-shell nanoparticles in three dimensions

Deciphering the structure and composition of bimetallic nanomaterial interfaces is key to understanding their properties. Here, the authors investigate the diffuse interfaces in Pd@Pt core-shell nanoparticles in 3D using electron tomography with atomic resolution.

Zezhou Li
Zhiheng Xie
Jihan Zhou
ResearchOpen Access22 May 2023
Nature Communications

Volume: 14, P: 1-10
Rewired m⁶A epitranscriptomic networks link mutant p53 to neoplastic transformation

The dysregulation of the m⁶A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upregulates the m⁶A reader YTHDF2, resulting in the initiation of gliomas.

An Xu
Mo Liu
Dung-Fang Lee
ResearchOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Self-similar fragmentation regulated by magnetic fields in a region forming massive stars

Polarimetric observations of magnetic-field orientations in a filamentary molecular cloud forming massive stars shows that the magnetic field strongly affects fragmentation in the region.

Hua-bai Li
Ka Ho Yuen
Keping Qiu
Research30 Mar 2015
Nature

Volume: 520, P: 518-521
Promoting nitrogen electroreduction to ammonia with bismuth nanocrystals and potassium cations in water

The electrochemical reduction of nitrogen to ammonia represents a challenge of major interest that would substantially decrease the burden of the energy-consuming Haber–Bosch process. Now, Yin, Yan, Zhang, Si and colleagues achieve high ammonia yield and Faradaic efficiency over 66% using bismuth nanocatalysts promoted by alkali cations.

Yu-Chen Hao
Yu Guo
Chun-Hua Yan
Research04 Mar 2019
Nature Catalysis

Volume: 2, P: 448-456
Metal-organic framework membranes with single-atomic centers for photocatalytic CO₂ and O₂ reduction

Photoreduction of permanent gas faces challenges in reactant diffusion and activation at the three-phase interface. Here the authors showed porous metal-organic framework membranes decorated by metal single atoms can boost the photoreduction of CO₂ and O₂ at the high-throughput gas-solid interface.

Yu-Chen Hao
Li-Wei Chen
Chun-Hua Yan
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-11
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice

Hyperglycemia induces endoplasmic reticulum stress and increases expression of MAPK10, and 4-phenylbutyric treatment and the knockdown of MAPK10 both alleviate hyperglycaemia-induced myocardial dysfunction, respectively. Therefore, the present study sheds new light on the novel role of MAPK10 in hyperglycemia-induced myocardial dysfunction in db/db mice.

Ya-Wen Deng
Fei Liu
Yun-Long Xia
ResearchOpen Access08 Aug 2022
Laboratory Investigation

Volume: 102, P: 1192-1202
Contributions of distinct gold species to catalytic reactivity for carbon monoxide oxidation

Nanoscale supported gold clusters are common redox catalysts but in many cases the nature of the active sites remains unclear. Here, the authors use X-ray absorption to determine the contribution of single gold atoms, clusters and particles on the reactivity of room-temperature carbon monoxide oxidation.

Li-Wen Guo
Pei-Pei Du
Chun-Hua Yan
ResearchOpen Access16 Nov 2016
Nature Communications

Volume: 7, P: 1-8
Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation

Bo Yuan
Han-Qing Liu
Shuo Song
ResearchOpen Access17 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
Polyhedral Palladium–Silver Alloy Nanocrystals as Highly Active and Stable Electrocatalysts for the Formic Acid Oxidation Reaction

Geng-Tao Fu
Chang Liu
Ya-Wen Tang
ResearchOpen Access02 Sept 2015
Scientific Reports

Volume: 5, P: 1-9
Prognostic Value of microRNA Signature in Patients with Gastric Cancers

Hai-Ting Liu
Ya-Wen Wang
Peng Gao
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
CD200R blockade enhances anti-tumor immunity by unleashing NK and CD8⁺ T cells in tumor

Zheng-feng Zhang
Yu Zhang
Hao-yu Sun
Research06 May 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2835-2848
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming

Ssu-Han Wang
Yu-Lin Chen
Ya-Wen Chen
ResearchOpen Access11 Mar 2025
Oncogenesis

Volume: 14, P: 1-13
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

Zi-yang Liu
Ya-wen Zhang
Xin-liang Mao
Research28 Aug 2024
Acta Pharmacologica Sinica

Volume: 46, P: 184-195
OliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets

OliTag-seq, a specific and reproducible in-cellulo assay for CRISPR/Cas9 off-target analysis, can improve site cleavage efficiency and the identification of off-target sites.

Zhi-Xue Yang
Dong-Hao Deng
Xiao-Bing Zhang
ResearchOpen Access06 Jun 2024
Communications Biology

Volume: 7, P: 1-15
Kondo scenario of the γ–α phase transition in single crystalline cerium thin films

Xie-Gang Zhu
Yu Liu
Xin-Chun Lai
ResearchOpen Access10 Jul 2020
npj Quantum Materials

Volume: 5, P: 1-9
Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications

Optimized lentiviral transduction enhances gene delivery in human iPSC-derived lung organoids, enabling advanced mechanistic studies in development and disease through improved protocols validated by scRNA-seq and molecular assays.

Jasmin Khateeb
Jady Liang
Haibo Zhang
ResearchOpen Access03 Feb 2025
Communications Biology

Volume: 8, P: 1-10
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Zhen Wang
Fan-lian Zeng
Jiong Li
ResearchOpen Access20 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-17
Predictive value of lymphocyte subsets and lymphocyte-to-monocyte ratio in assessing the efficacy of neoadjuvant therapy in breast cancer

Hao Zhang
Yan Li
Xin Chen
ResearchOpen Access04 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

Thitikorn Duangupama
Jaturong Pratuangdejkul
Chitti Thawai
ResearchOpen Access24 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

Sally Yu Shi
Ya-Wen Lu
Yang Li
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-15
Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells

Yu-Lin Chen
Wan-Lin Wu
Ya-Wen Chen
Research14 Feb 2019
Oncogene

Volume: 38, P: 4480-4495
Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma

Shih-Miao Li
Chung-Hsing Chen
Shih Sheng Jiang
ResearchOpen Access19 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids

Min Liu
Yi Liu
Hui Wang
Research25 Oct 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1461-1472
MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells

Shu-Hua Fu
Mei-Chen Lai
Fei Liu
ResearchOpen Access15 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-12
A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity

Jia-Yuan Wang
Lian Zhou
Ya-Wen He
ResearchOpen Access17 Dec 2015
Scientific Reports

Volume: 5, P: 1-13
PdCo/Pd-Hexacyanocobaltate Hybrid Nanoflowers: Cyanogel-Bridged One-Pot Synthesis and Their Enhanced Catalytic Performance

Zhen-Yuan Liu
Geng-Tao Fu
Ya-Wen Tang
ResearchOpen Access30 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201

Shuang Sun
Lian Zhou
Ya-Wen He
ResearchOpen Access26 Jul 2016
Scientific Reports

Volume: 6, P: 1-14
Mass spectrometry imaging: new eyes on natural products for drug research and development

Jin-jun Hou
Zi-jia Zhang
De-an Guo
Reviews13 Oct 2022
Acta Pharmacologica Sinica

Volume: 43, P: 3096-3111

Search

Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

Tunning valence state of cobalt centers in Cu/Co-CoO_1-x for significantly boosting water-gas shift reaction

Integrated transcriptional and biochemical profiling suggests mechanisms associated with rapid cold hardening in adult Liriomyza trifolii (Burgess)

Publisher Correction: Promoting nitrogen electroreduction to ammonia with bismuth nanocrystals and potassium cations in water

Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model

Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate

Probing the atomically diffuse interfaces in Pd@Pt core-shell nanoparticles in three dimensions

Rewired m⁶A epitranscriptomic networks link mutant p53 to neoplastic transformation

Self-similar fragmentation regulated by magnetic fields in a region forming massive stars

Promoting nitrogen electroreduction to ammonia with bismuth nanocrystals and potassium cations in water

Metal-organic framework membranes with single-atomic centers for photocatalytic CO₂ and O₂ reduction

Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice

Contributions of distinct gold species to catalytic reactivity for carbon monoxide oxidation

Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation

Polyhedral Palladium–Silver Alloy Nanocrystals as Highly Active and Stable Electrocatalysts for the Formic Acid Oxidation Reaction

Prognostic Value of microRNA Signature in Patients with Gastric Cancers

CD200R blockade enhances anti-tumor immunity by unleashing NK and CD8⁺ T cells in tumor

A second update on mapping the human genetic architecture of COVID-19

Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming

Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

OliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets

Kondo scenario of the γ–α phase transition in single crystalline cerium thin films

Optimized gene transduction in human lung organoids: A high-efficiency method for advanced research applications

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Predictive value of lymphocyte subsets and lymphocyte-to-monocyte ratio in assessing the efficacy of neoadjuvant therapy in breast cancer

New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells

Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma

Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids

MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells

A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity

PdCo/Pd-Hexacyanocobaltate Hybrid Nanoflowers: Cyanogel-Bridged One-Pot Synthesis and Their Enhanced Catalytic Performance

Quorum sensing systems differentially regulate the production of phenazine-1-carboxylic acid in the rhizobacterium Pseudomonas aeruginosa PA1201

Mass spectrometry imaging: new eyes on natural products for drug research and development

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