Search

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

This study presents a plausible emissions scenario aligned with China’s net-zero path, with CO₂ peaking in concentration by 2062 and net-zero in emissions by 2072. It projects 2.01 °C warming by 2100, with potential to stabilize below 2 °C after 2100.

C–H bond functionalization has become an important tool for many organic transformations, however such reactions typically require stoichiometric amounts of external oxidants. Here the authors report the photo-driven decarboxylative C–H trifluoromethylation of arenes using only low amounts of oxidant.

Nelson et al. report that the APOE-R136S mutation protects against APOE4-promoted Alzheimer’s disease pathologies, including phosphorylated Tau accumulation, neuroinflammation and neurodegeneration, in mouse and human neuron models.

Egg-laying performance is an important phenotype for breeding chicken. Here, the authors explore the regulatory networks driving phenotypic differences in egg-laying, and identify laying-related variants and endocrine factors.

Selective neurodegeneration is a critical causal factor in Alzheimer’s disease. Zalocusky et al. demonstrate a causal chain linking neuronal ApoE expression to MHC-I expression and, subsequently, to tau pathology and selective neurodegeneration.

Through computational drug repurposing, Taubes et al. identified bumetanide as a potential drug for APOE4-related Alzheimer’s disease (AD). The effectiveness of bumetanide was validated in AD mouse models and via real-world health record databases.

Here, Wang et al. show that heat-inactivated Bifidobacterium adolescentis mediates maintenance of host intestinal barrier through intestinal stem cells activation, which can potentially have translational implications for alleviation of colon senescence and related diseases.

APOE4 is produced by neurons under stress, but the role of neuronal APOE4 in Alzheimer’s disease pathogenesis is still unclear. Here the authors report that selective removal of neuronal APOE4 in tauopathy mice mitigates many prominent Alzheimer’s disease-related pathologies.

The authors study the layered superconductor AuSn₄ (T_c = 2.4 K) and reveal a two-fold symmetric angular dependence, consistent with unconventional pairing. They argue that the two-fold symmetry results from the Rashba-driven mixture of p-wave surface and s-wave bulk contributions.

Human iPSC-derived neurons are generated from individuals with or without Alzheimer's disease carrying different APOE alleles and reveal a toxic, neuron-intrinsic gain of function of the ApoE4 variant that is a strong genetic risk factor for AD.

The inactivation of natural enzymes by radiation hinders their utility for radiotherapy. Here the authors report a single-atom copper nanozyme that can be utilized for enhanced radio-enzymatic therapy to resolve the crucial issues for the applications of natural enzymes.

Researchers demonstrate the high-coherence parallelization in integrated photonics. Their high-coherence, high-power, multiwavelength light source drives a silicon photonic link with a 60 Tbit/s data rate and significantly reduces digital signal processing consumption.

New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development of specialized research strategies, treatment approaches and clinical trials.

Enveloped viruses encased within a lipid bilayer membrane are highly contagious and cause diseases like influenza and COVID-19, so strategies for their prevention and inactivation are needed. Here, the authors develop a diatomic iron nanozyme with lipoxidase-like activity for the inactivation of enveloped viruses, where the diatomic iron sites destroy the viral envelope via lipid peroxidation.

A microglial state, featuring lipid droplets and secretion of neurotoxic factors, is shown to be most prominent in people with Alzheimer’s disease who have the APOE4 genotype.

Sun and colleagues describe that the secretion of interleukin-33 is dependent on a p40 N-terminal fragment of gasdermin D, whose generation is independent of inflammatory caspase-1 and caspase-11.

Designing and enhancing the performance of metal single-atom nanozymes (SAzymes) through atom-pair engineering is important yet difficult. Here the authors develop the atom-pair engineering of Zn-SA/CNCl SAzyme by concurrently creating Zn-N₄ sites as catalytic sites and Zn-N₄Cl₁ sites as catalytic regulators.

The development of a tandem catalyst, consisting of two distinct nanoscale-engineered layers, enables efficient multicarbon production with high CO₂ utilization in an acidic CO₂ electroreduction environment.

Atomically dispersed Rh on N-doped carbon exhibits 28- and 67-fold enhancements compared with state-of-the-art Pd/C and Pt/C, despite the low activity of Rh/C. The Rh single atoms exhibit high tolerance to CO poisoning compared to Rh nanoparticles.

The tailored synthesis of heterostructured intermetallic nanomaterials (iNMs) is challenging. Now, a galvanic replacement strategy is reported for the construction of a library of iNMs. Layered interfacial growth produces intermetallic heterostructures with controllable compositions, structures and interfaces.

Incorporating oxophilic metals into noble metal catalysts can improve electrocatalytic performance; however, the influence of the distance between noble metal and oxophilic metal active site is not well understood. Here the authors make Pd–Ni–P nanocatalysts for ethanol oxidation, with improved performance achieved by shortening the Pd–Ni distance.

Catalysts with improved hydrogen activation and substrate adsorption are required for advanced hydrogenation applications. Here, the authors fabricate metal organic framework coated platinum–nickel catalyst exhibiting enhanced hydrogenation activity and substrate selectivity due to molecular sieving effects.

Atom trapping is a well-established route to prepare single-atom catalysts. Here the authors propose a reverse atom-trapping strategy in which surface strontium atoms of LSCF fuel cell cathodes are extracted by MoO₃, forming single strontium vacancies on LSCF in a controllable manner and tuning its performance for the oxygen reduction reaction.

Within the CNS, APOE4 — a risk factor for late-onset Alzheimer disease — is produced by a variety of cell types. Blumenfeld, Yip, Kim and Huang discuss recent scientific advances that have begun to unravel the cell type-specific roles of APOE4 and outline a corresponding cell type-specific APOE4 cascade model of Alzheimer disease.

Welwitschia mirabilis is a unique plant that only has two leaves, but it can survive in hostile conditions of the African desert. Here, the authors report its chromosome-level genome assembly and discuss how gene function and regulation have given rise to its unique morphology and environmental adaptions.

Research on the bulk internal electric field (IEF) regulation is significant for designing high-efficiency photocatalysts. Here, the authors report distinctive bismuth oxyhydroxide nanorods photocatalyst and increase the bulk IEF intensity by halogen ions exchange.

Ensuring robustness of bound states in the continuum usually relies on precise control of geometrical symmetries, which are quite susceptible to fabrication imperfections. Here, the authors propose to exploit physical symmetries instead, as a way to achieve robust BICs in disordered systems.

While Ru-based electrocatalysts are among the most active for acidic water oxidation, they suffer from severe deactivation. Now, Yuen Wu, Wei-Xue Li and co-workers report a core–shell Ru₁–Pt₃Cu catalyst with surface-dispersed Ru atoms for a highly active and stable oxygen evolution reaction in acid electrolyte.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.

Defective oxides are attractive for energy conversion and storage applications, but it remains challenging to implant defects in oxides under mild conditions. Here, the authors develop a versatile lithium reduction strategy to engineer the defects of oxides at room temperature leading to enhanced photocatalytic properties.

Homozygous APOE3-Christchurch (R136S) mutation protects a presenilin 1 (PSEN1) mutation carrier from developing Alzheimer’s disease until her seventies.

Single-atom catalysts are very attractive due to their ability to maintain high activities at the lowest possible precious metal loading. Here, a double transition metal MXene that effectively anchors single Pt atoms is reported, and exhibits superior performance and stability towards the hydrogen evolution reaction.

Atomically dispersed metal catalysts are of increasing importance in many catalytic processes, but clear structural identification is challenging. Here, a general synthesis of metal (nickel, iron and cobalt) single-atom catalysts on nitrogen-doped graphene allows the authors to identify a common structure and furthermore correlate structure with electrocatalytic activity.

Bio-oil is a potential major source of renewable fuels and chemicals. Here, the authors report a palladium-molybdenum mixed catalyst for the selective hydrodeoxygenation of water-insoluble bio-oil to mixtures of alkanes with high carbon yield.