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The streamlined dual-functional group transfer strategy represents an efficient and sustainable approach for difunctionalization reactions, where all atoms or functional groups from the starting materials are fully incorporated into the final products. Herein, the authors report a regioselective pyridylcyanation of internal alkynes enabled by an oxalate-based photocatalytic system, employing cyanopyridine as a streamlined dual-functional group transfer reagent.

The Antarctic Circumpolar Current (ACC) since the Last Interglacial is reconstructed, showing orbital-scale shifts in ACC position driven by eccentricity and precession, possibly counteracting the predicted southward shift due to global warming.

The precise synthesis of enantiomerically enriched helicenes has attracted considerable interest in material science and chiral catalysis, but synthetic strategies for helical chirality remain relatively limited. Here, the authors report a chiral scandium(III)-catalyzed ring-expansion and kinetic resolution of racemic helical fluorenones with α-diazo esters.

Radiative cooling is an emerging technology for cooling with reduced energy consumption. Here the authors present photoluminescent composites that combine subambient cooling with aesthetic colour, hydrophobicity and durability.

Myasthenia gravis (MG) is an autoimmune condition leading to extreme muscle weakness due to autoantibodies targeting the neuromuscular junctions. Here authors assign a critical role for platelets in amplifying the pro-inflammatory response in AChR+ immunotherapy-naïve MG (nMG) patients and thus contributing to disease pathology.

In this clinical trial, the authors demonstrate that recombinant gE-Fc Fusion Protein Vaccine LZ901 for herpes zoster induces superior cellular immunogenicity and exhibits a better safety profile than HZ/su in adults ≥50 years, supporting its potential as vaccine candidate.

Above-bandgap femtosecond laser pulses generate a coherent phonon flatband in a GaAs/AlAs superlattice captured using ultrafast X-ray diffraction, providing a way to control atomic vibrations for future electronic and quantum technologies.

Monocytes derived from bone marrow leucocytes are chemically conjugated with a Tau-specific aptamer via bioorthogonal chemistry, enabling systemic delivery across the blood–brain barrier and targeted clearance of extracellular Tau in Alzheimer’s disease mouse models.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

SARST2 enables rapid exploration of protein structure space. In minutes, it scans the 214-million-entry AlphaFold Database on a personal computer, revealing homologs with higher accuracy and lower memory/disk usage than leading methods.

Autonomous artificial intelligence (AI) models to replace human decision-making in medical intervention need thorough testing. Here authors present the results of a clinical trial, NCT05600855, in which daGOAT, a conditional autonomous artificial intelligence agent successfully makes the decision whether to prescribe an immune suppressive drug to prevent severe acute graft-versus-host disease following HLA-mismatched haematopoietic cell transplantation.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Mechanical cues are critical regulators of cell fate and behavior. Here, the authors present a magneto-responsive nanomesh that mechanically stimulates cells and simultaneously detects the triggered biomolecules

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

An in-built fluoropolyether-based quasi-solid-state polymer electrolyte enables high-capacity lithium-rich manganese-based layered oxide cathodes with stable interfaces, achieving 604 Wh kg⁻¹ pouch-cell energy density.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

This study identifies TriDTCs as a family of terpene cyclases responsible for harzianol I and wickerol A biosynthesis in Trichoderma fungi and are found to regulate Trichoderma’s chlamydospore and Aspergillus oryzae’s sclerotia formation through producing harzianol I.

Vascular calcification, a key risk factor of cardiovascular diseases, involves smooth muscle cells shifting to osteogenic phenotype. Here, the authors show that NEXN inhibits this process and protects against calcification by stabilizing SERCA2.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Few studies have evaluated how climate change may affect dietary habits and nutritional health. Here, using transaction data in the USA, the authors show that added sugar consumption increases with temperature, especially between 12 °C and 30 °C, with stronger effects among lower-income and lower-education groups.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Here the authors report a retrospective analysis showing lower risk of composite outcomes of all-cause hospitalization, all-cause mortality, major adverse cardiovascular events, major adverse kidney events and major adverse liver outcomes for patients with MASLD treated with combination therapy with GLP-1 receptor agonists and SGLT2 inhibitors versus SGLT2 inhibitor monotherapy. However, a sensitivity analyses suggests that these effects may be driven by the GLP-1 receptor agonist treatment.

Intracellular α-ketoglutarate availability dictates energy sensing through regulation of TET–YBX1-dependent AMP-activated protein kinase synthesis, which prevents disulfide stress accumulation and cell death in cancer cells.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Staple crop production in China involves high levels of synthetic fertilizer use and losses to the environment. Using a localized nitrogen management model for wheat, maize and rice, this study estimates the environmental and economic benefits of improving nitrogen use efficiency at the county level.

Chen et al. report a lattice-matched molecule, tris(4-methoxyphenyl) phosphine oxide, to anchor multi-site defects and stabilise the lattice of perovskite quantum dots, enabling deep-red LEDs with efficiency up to 26.91% at 693 nm. The air-processed devices can still maintain an efficiency of 26.28%.

Quantum information cannot be copied, posing challenges for long-distance communication due to signal losses. Here the quantum relay architecture using a single-photon source enhances the signal-to-noise ratio of quantum information transmission.

Methods of damaging cancer cells are of therapeutic interest. Here, the authors report on using gold nanoparticles as electron sinks with electroactive bacterial membranes to disrupt cancer cell redox balance, electron transfer induces oxidative stress and triggers cell death by apoptosis.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Desmocollin 2 (DSC2) binds to the EBV glycoprotein H/glycoprotein L complex and allows for virus entry to epithelial cells, which could be blocked by DSC2-specific antibodies. DSC2 allowed for virus entry independent of Ephrin receptor A2.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

In a multicenter randomized phase 3 trial, stapokibart, a humanized monoclonal antibody that targets IL-4R alpha, significantly improved daily nasal and ocular symptom scores during the pollen phase in patients with moderate-to-severe seasonal allergic rhinitis.

Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce T cell exhaustion and contribute to platelet activation.

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.