Nature Search

Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues

This work presents MAPIT-seq, an antibody-guided RNA editing method that enables co-profiling of RBP-RNA interactions and gene expression at single-cell resolution and in tissue contexts.

Qi-Xuan Cheng
Gang Xie
Yangming Wang
ResearchOpen Access11 Aug 2025
Nature Methods

Volume: 22, P: 1824-1835
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human

A new computational method coupled with a CRISPR–Cas12a screen identifies human long noncoding RNAs (lncRNAs) that lead to cell proliferation defects, which can be rescued by zebrafish homologs. Knockdown of four zebrafish lncRNAs that perturb embryonic development can be rescued by human homologs.

Wenze Huang
Tuanlin Xiong
Qiangfeng Cliff Zhang
ResearchOpen Access09 Jan 2024
Nature Genetics

Volume: 56, P: 124-135
DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing

There is a need to improve and expand mitochondrial base editing tools. Here the authors identify a DddA homolog from Simiaoa sunii (Ddd_Ss) which can efficiently deaminate cytosine in dsDNA; they develop cytosine base editors and introduce mutations at multiple mitochondrial DNA loci.

Li Mi
Ming Shi
Yangming Wang
ResearchOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1-9
Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Xinyu Qi
Chuyu Yun
Jie Qiao
Amendments and Corrections30 Aug 2019
Nature Medicine

Volume: 25, P: 1459
Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan

Wedemeyer et al. find that age-associated waning of T-cell responses to infection and tolerance to self are regulated by a dynamic paracrine FGF21 signaling axis modulating mTORC1 and mTORC2 activity in thymic epithelial cells in mice.

Sarah A. Wedemeyer
Nicholas E. Jones
Ann V. Griffith
Research19 Feb 2025
Nature Aging

Volume: 5, P: 588-606
Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

The authors develop a metabolic engineering strategy for improving polyketide production of industrial interest and discovering new natural products in bacteria.

Xinran Wang
Ningxin Chen
Xiaozhou Luo
Research12 Apr 2024
Nature Metabolism

Volume: 6, P: 933-946
A deep learning based prediction model for effective elastic properties of porous materials

Chang Liu
Ran Guo
Yangming Su
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-14
Association between probiotics and bronchopulmonary dysplasia in preterm infants

Yangming Qu
Shijie Guo
Hui Wu
ResearchOpen Access23 Aug 2021
Scientific Reports

Volume: 11, P: 1-6
Analysis of Dose-response Relationship between BMI and Hypertension in Northeastern China Using Restricted Cubic Spline Functions

Yangming Qu
Niu HuiKun
Hui Wu
ResearchOpen Access03 Dec 2019
Scientific Reports

Volume: 9, P: 1-7
NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

The lncRNA NEAT1, a key component of paraspeckles, interacts with RNA-binding proteins, including NONO and PSF, and affects global pri-miRNA processing by recruiting the Drosha–DGCR8 Microprocessor.

Li Jiang
Changwei Shao
Xiang-Dong Fu
Research28 Aug 2017
Nature Structural & Molecular Biology

Volume: 24, P: 816-824
Mantle-driven plate convergence due to slab detachment

Mantle flow induced by slab detachment plays a key role in regulating plate convergence, with spreading ridges and continent-trench collisions causing significant tectonic uplift and acceleration of plate motion, according to numerical modelling of lithosphere-mantle dynamics.

Yangming Wu
Manuele Faccenda
Zhongping Lai
ResearchOpen Access22 Jun 2025
Communications Earth & Environment

Volume: 6, P: 1-12
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Modifying the gut microbiota, bile acid, or IL-22 may offer an alternative approach for the treatment of polycystic ovary syndrome.

Xinyu Qi
Chuyu Yun
Jie Qiao
Research22 Jul 2019
Nature Medicine

Volume: 25, P: 1225-1233
A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study

Shi-wei Hu
Xiu-di Yang
Jian Huang
ResearchOpen Access18 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Influence of concurrent chemotherapy on locoregionally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy plus intensity-modulated radiotherapy: A retrospective matched analysis

Fangzheng Wang
Chuner Jiang
Yangming Jiang
ResearchOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2

Pan Wang
Sheng Gong
Bin Liao
ResearchOpen Access13 May 2021
Cell Death Discovery

Volume: 7, P: 1-14
ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer

Yangming Hou
Yingjuan Xu
Dequan Wu
ResearchOpen Access26 May 2021
Scientific Reports

Volume: 11, P: 1-16
Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency

Kai-Li Gu
Qiang Zhang
Yangming Wang
ResearchOpen Access08 Jan 2016
Cell Research

Volume: 26, P: 350-366
A cross-sectional study about the relationship between physical activity and sarcopenia in Taiwanese older adults

Yun-Chen Ko
Wei-Chu Chie
Wen-Ruey Yu
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Downregulation of testosterone production through luteinizing hormone receptor regulation in male rats exposed to 17α-ethynylestradiol

Po-Han Lin
Tsung-Hsien Kuo
Shyi-Wu Wang
ResearchOpen Access31 Jan 2020
Scientific Reports

Volume: 10, P: 1-13
Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women

W H Wu
S C Lu
T A Wang
Research09 Nov 2005
European Journal of Clinical Nutrition

Volume: 60, P: 386-392

Search

Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues

Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human

DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing

Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Paracrine FGF21 dynamically modulates mTOR signaling to regulate thymus function across the lifespan

Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

A deep learning based prediction model for effective elastic properties of porous materials

Association between probiotics and bronchopulmonary dysplasia in preterm infants

Analysis of Dose-response Relationship between BMI and Hypertension in Northeastern China Using Restricted Cubic Spline Functions

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

Mantle-driven plate convergence due to slab detachment

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

A nomogram for predicting T315I-free survival in chronic phase chronic myeloid leukemia patients: a multicenter retrospective study

Influence of concurrent chemotherapy on locoregionally advanced nasopharyngeal carcinoma treated with neoadjuvant chemotherapy plus intensity-modulated radiotherapy: A retrospective matched analysis

Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2

ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer

Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency

A cross-sectional study about the relationship between physical activity and sarcopenia in Taiwanese older adults

Downregulation of testosterone production through luteinizing hormone receptor regulation in male rats exposed to 17α-ethynylestradiol

Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women

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