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Showing 1–9 of 9 results

Advanced filters: Author: Yangxue Li Clear advanced filters

Structural insights into the activation mechanism of the human zinc-activated channel

ZAC is a Zn²⁺ and H⁺-activated cation channel. Here, the authors report the structures of human ZAC and identify an unusual C-tail that functions in auto-inhibition. This work provides insights into the gating and activation mechanisms of ZAC.

Xuhang Lu
Dongmei Li
Yuequan Shen
ResearchOpen Access07 Jan 2025
Nature Communications

Volume: 16, P: 1-12
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3

Two mGlu3–βarr1 cryo-EM structures with 2:1 and 2:2 stoichiometries are reported, revealing that the inactive state involves mGlu3 engagement of βarr1 through phosphorylated C-terminal tail and intracellular loops.

Tianlei Wen
Mei Du
Xue Yang
Research06 Mar 2025
Nature Chemical Biology

Volume: 21, P: 1262-1269
Molecular basis of Mg²⁺ permeation through the human mitochondrial Mrs2 channel

Mrs2 is a mitochondrial Mg2+ channel that is essential for metabolic function. Here, the authors present cryo-EM structures of human Mrs2 revealing symmetrical pentameric assembly and how Mrs2 permeates Mg²⁺.

Ming Li
Yang Li
Yuequan Shen
ResearchOpen Access05 Aug 2023
Nature Communications

Volume: 14, P: 1-11
Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

Store-operated calcium entry (SOCE) is elicited by the interaction of oligomerized STIM1 with plasma membrane Orai channels. Here, the authors show that this process is regulated by calmodulin, which binds STIM1 and disassembles the STIM1-Orai1 complex and STIM1 oligomers.

Xin Li
Guangyan Wu
Yuequan Shen
ResearchOpen Access19 Oct 2017
Nature Communications

Volume: 8, P: 1-14
Anti-liver tumor ingredient exploration and validation of Elephantopus tomentosus Linn. by combining in silico and in vitro experiments

Zhihao Zeng
Canchao Jia
Xiaoli Bi
ResearchOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1-14
Deciphering the mechanisms of Yinlan Tiaozhi capsule in treating hyperlipidemia by combining network pharmacology, molecular docking and experimental verification

Guanlin Xiao
Zixuan Hu
Xiaoli Bi
ResearchOpen Access19 Apr 2023
Scientific Reports

Volume: 13, P: 1-19
Network pharmacology analysis and experimental validation to explore the mechanism of Bushao Tiaozhi capsule (BSTZC) on hyperlipidemia

Guanlin Xiao
Zhihao Zeng
Xiaoli Bi
ResearchOpen Access28 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Minimally invasive techniques for lateral maxillary sinus floor elevation: small lateral window and one-stage surgery—a 2–5-year retrospective study

Shaojingya Gao
Yao Jiang
Xiaoxiao Cai
ResearchOpen Access11 Jul 2023
International Journal of Oral Science

Volume: 15, P: 1-10
CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence

Luhua Li
Yangfei Xing
Yuequan Shen
ResearchOpen Access19 Aug 2016
Scientific Reports

Volume: 6, P: 1-12