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Ion association in electrolytes enables a robust protective layer on battery electrodes but compromises thermal stability. Here Yi-Chun Lu and colleagues develop an electrolyte-based strategy that preserves this benefit while enabling safer lithium-ion batteries.

FADD binds Casp-8 and then cFLIP to form the FADD-Casp8-cFLIP complex. The authors found that the DED complex could assemble in reverse order, where cFLIP oligomerizes to bind Casp-8. The resultant complex could bind FADD, generating the cFLIP-Casp-8-FADD complex by a different mechanism.

Dong et al. demonstrate that targeting arginine N-methyltransferase 9 (PRMT9) inhibits cancer stem cells in the context of acute myeloid leukemia via type I interferon-associated immunity. Furthermore, they show that PRMT9 inhibition synergizes with anti-programmed cell death protein 1.

How Draper activates phagocytosis is not well understood. Here, the authors show that two Drosophila galectins, Hdg and Ctg, are secreted from hemocytes after dendrite injury and bridge phosphatidylserine and Draper to active phagocytosis.

The authors deploy a hydrotropic solubilization strategy turning an otherwise poorly water-soluble acetate into a salt for a high-concentration aqueous electrolyte that features low cost and environmental sustainability and enables good performance of zinc batteries.

Analyses of whole-exome sequencing data identify rare loss-of-function variants in BSN associated with adult-onset obesity, type 2 diabetes and fatty liver disease, with stronger effect sizes than those observed for variants in known obesity risk genes such as MC4R.

Coordination chemistry has a pivotal role in advancing redox-active electrolytes for energy technologies. This Review examines how ligand properties and coordination effects shape electrolyte thermodynamics, kinetics and electrochemical performance, guiding the rational design of next-generation aqueous redox flow batteries.

Genome-wide siRNA screens identify an essential function for sorting nexin 5 in virus-induced autophagy and immunity mediated via class III phosphatidylinositol-3-kinase complex 1.

Self-assembled nanocomposites present opportunities for a range of phase morphologies and desirable properties. Here authors present tuneable self-assembled nanostructures in the SnO2:NiO system; the double-percolated system expands the design of self-assembled oxides for practical applications, e.g. in optoelectronics.

Tumor-associated macrophages can restrict antitumor responses. Barreira da Silva and colleagues demonstrate that the intracellular enzyme QPCTL supports recruitment of immunomodulatory macrophages to the tumor microenvironment and its targeting can enhance tumor control.

Interim analysis from the randomized phase 3 JUPITER-02 trial shows that the addition of anti-PD-1 toripalimab to standard gemcitabine/cisplatin as a first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma has manageable toxicity and improves progression-free survival, suggesting a potential new treatment standard in this setting.

Wu et al. show that prosurvival BCL-2 proteins disrupt SUFU repression of GLI activity, leading to GLI target gene expression. BH3 mimetics disable GLI transcriptional activity driven by HH pathway mutations.

The development of aqueous redox flow batteries (ARFBs) has been plagued by high material costs and poor operating stability. Here the authors report a membrane design to enable polysulfide-based ARFBs with minimal capacity decay over long cycles and durations as well as competitive cost-effectiveness.

Stable and high-power operation of aqueous redox flow batteries (ARFBs) is desirable for grid storage in cold climate regions. Here the authors report a heteropoly acid electrolyte with an exceptionally low freezing point and high conductivity that enables high-performance ARFBs at low temperatures.

Hedgehog signalling gradients are required for proper wing formation inDrosophila, and Hedgehog is known to regulate the cubitus interruptus transcription factor. Here, the authors show that the COP9 signalosome has a critical role in translating a Hedgehog gradient into a cubitus interruptus gradient.

Developing cheap and sustainable aqueous electrolytes with a wide voltage window is key to achieving safe and high-energy Li-ion batteries. An electrolyte using the polymer poly(ethylene glycol) as a crowding agent to decrease water activity achieves a wide operation window at low salt concentration.

Microbial sulfur oxidation in the stream channel during periods of high flow, along with erosion, modulates carbonate weathering and carbon dioxide cycling in a rapidly uplifting catchment in Taiwan, according to combined analyses of riverine geochemistry and microbial communities.

By implementing the conditions for orthotopic implantation of different types of human breast tumors, the authors have created a publicly available bank of new mouse models that more faithfully recreate individual tumor properties and provide individualized information about tumor behavior and prognosis.

Two specific inhibitors for emerging cancer therapy target malic enzyme 2 (ME2) are identified and are shown to bind to one of ME2 allosteric sites, resulting in inactive open conformation, inhibiting ME2-mediated cellular respiration and ATP production in the cell

In this work we report the electrical polarization can be induced by composition-graded LaAlO₃-SrTiO₃ solid solution. The analysis indicates that the induced polarization is attributed to the flexoelectric effect in the compositional gradient system. By a suitable combination of compositional gradient in geometry, a local conduction can be created and manipulated, delivering a new approach to obtain unveiled properties. delivering a new pathway to acquire material genome based on material inhomogeneity.

Developing green-emitting InP quantum dot light-emitting diodes (QLED) is lagging behind their red and green counterparts. Here, green InP quantum dots are prepared and incorporated into a QLED so to promote hole transport and reduce electron mobility, resulting in a maximum quantum efficiency of 16.3 %.