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Scientific Reports (24)
Acta Pharmacologica Sinica (17)
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Showing 1–50 of 83 results

Advanced filters: Author: Yi-Ping Li Clear advanced filters

Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

Yi-ping Zhu
Kun Xiao
Jing-kang Shen
Research26 Jan 2009
Acta Pharmacologica Sinica

Volume: 30, P: 259-269
Analysis of the temperature evolution of the canned motor with spiral tube heat exchanger in secondary water supply blackout fault

Li-Kun Ai
Yi-Ping Lu
ResearchOpen Access07 Oct 2025
Scientific Reports

Volume: 15, P: 1-11
Spindle oscillations are generated in the dorsal thalamus and modulated by the thalamic reticular nucleus

Chun-Hua Liu
Yi Ping Guo
Jufang He
ResearchOpen Access19 Sept 2008
Nature Precedings

P: 1
B cells induced regulatory T cells attenuated the classical M1 polarization of mouse bone marrow-derived macrophages

Yi-Ping Huang
Chien-Hui Chien
Bor-Luen Chiang
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-12
Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent

Dong-lu Bai
Wei-zhou Chen
Yi-ping Wang
Research27 Aug 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1176-1186
Towards a holistic framework for multimodal LLM in 3D brain CT radiology report generation

Multimodal large language models (MLLMs) hold promise for a range of medical applications. Here, the authors use MLLMs for 3D brain CT radiology report generation, demonstrating that combining anatomy-aware model fine-tuning with robust evaluation metrics establishes a comprehensive and effective framework.

Cheng-Yi Li
Kao-Jung Chang
Shih-Hwa Chiou
ResearchOpen Access06 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Doppler flowmetry

Xiao-fen Li
Yi-ping Wang
Research01 Jun 2007
Acta Pharmacologica Sinica

Volume: 28, P: 789-795
Prevention of lipopolysaccharide-induced injury by 3,5-dicaffeoylquinic acid in endothelial cells

Ruo-peng Zha
Wei Xu
Yi-ping Wang
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1143-1148
Magnesium lithospermate B ameliorates renal cortical microperfusion in rats

Chun-guang Chen
Yi-ping Wang
Research01 Feb 2006
Acta Pharmacologica Sinica

Volume: 27, P: 217-222
Inhibitory effects of lithospermic acid on proliferation and migration of rat vascular smooth muscle cells

Li Chen
Wen-yi Wang
Yi-ping Wang
Research24 Aug 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1245-1252
Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy

Combining expansion microscopy (ExM) with lightsheet imaging can enable fast 3D visualisation of biological structures at high-resolution, but such approaches can be hindered by several limitations. By using potassium acrylate-based hydrogels, the authors perform large-volume ExM with Bessel lightsheet microscopy, achieving high-resolution imaging of cellular structures within the fly brain.

Xuejiao Tian
Tzu-Yang Lin
Bi-Chang Chen
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that the galectin-3 NTD undergoes liquid-liquid phase separation (LLPS) and agglutinates other molecules through this process.

Yi-Ping Chiu
Yung-Chen Sun
Jie-rong Huang
ResearchOpen Access06 Mar 2020
Nature Communications

Volume: 11, P: 1-12
Rewired m⁶A epitranscriptomic networks link mutant p53 to neoplastic transformation

The dysregulation of the m⁶A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upregulates the m⁶A reader YTHDF2, resulting in the initiation of gliomas.

An Xu
Mo Liu
Dung-Fang Lee
ResearchOpen Access27 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Expression and purification of lipoprotein-associated phospholipase A₂, a key enzyme involved in atherosclerosis

Fu-jun Zhang
Mao-jun Cai
Yi-ping Wang
Research01 Jun 2006
Acta Pharmacologica Sinica

Volume: 27, P: 679-684
Effects of scutellarin on PKCγ in PC12 cell injury induced by oxygen and glucose deprivation

Wei Xu
Ruo-peng Zha
Yi-ping Wang
Research01 Oct 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1573-1579
Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease

Aging increases the risk for Alzheimer’s disease (AD). Here, the authors present a spatial transcriptome atlas of the human prefrontal cortex in AD, revealing distinct transcriptional alterations.

Yun Gong
Mohammad Haeri
Hong-Wen Deng
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth

Antibiotics reduce the fraction of active ribosomes rather than slow translational elongation, a process also observed during E. coli adaptation to slow-growth conditions.

Xiongfeng Dai
Manlu Zhu
Terence Hwa
Research12 Dec 2016
Nature Microbiology

Volume: 2, P: 1-9
Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats

Cheng-haung Wang
Wen-ying Chou
Tsung-hsing Lee
Research01 Jan 2005
Acta Pharmacologica Sinica

Volume: 26, P: 46-50
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.

Jin-Yu Yang
Xiang-Yu Deng
Song Gao
ResearchOpen Access21 Mar 2018
Nature Communications

Volume: 9, P: 1-13
Involvement of estrogen receptor-β in farrerol inhibition of rat thoracic aorta vascular smooth muscle cell proliferation

Qun-yi Li
Li Chen
Ming-wei Wang
Research14 Mar 2011
Acta Pharmacologica Sinica

Volume: 32, P: 433-440
Author Correction: Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway

Mengrui Wu
Wei Chen
Yi-Ping Li
Amendments and CorrectionsOpen Access25 Nov 2019
Nature Communications

Volume: 10, P: 1-5
Magnesium lithospermate B dilates mesenteric arteries by activating BK_Ca currents and contracts arteries by inhibiting K_V currents

Hai-fei Zhang
Xue-qing Chen
Yi-ping Wang
Research10 May 2010
Acta Pharmacologica Sinica

Volume: 31, P: 665-670
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification

Yi-Ping Li
Wei Chen
Philip Stashenko
Research01 Dec 1999
Nature Genetics

Volume: 23, P: 447-451
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

Cachexia affects many cancer patients causing weight loss and increasing mortality. Here, the authors identify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor cells, to be responsible for tumor induction of cachexia.

Guohua Zhang
Zhelong Liu
Yi-Ping Li
ResearchOpen Access19 Sept 2017
Nature Communications

Volume: 8, P: 1-16
Betulin attenuates atherosclerosis in apoE^−/− mice by up-regulating ABCA1 and ABCG1

Yu-zhou Gui
Hong Yan
Yi-ping Wang
Research04 Jul 2016
Acta Pharmacologica Sinica

Volume: 37, P: 1337-1348
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation

Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons.

Yu-Tzu Shih
Yi-Ping Hsueh
ResearchOpen Access17 Mar 2016
Nature Communications

Volume: 7, P: 1-16
Responses of soil microbial activity to cadmium pollution and elevated CO₂

Yi Ping Chen
Qiang Liu
Xin Hua He
ResearchOpen Access06 Mar 2014
Scientific Reports

Volume: 4, P: 1-6
Nerve Growth Factor and Vascular Endothelial Growth Factor: Retrospective Analysis of 63 Patients with Salivary Adenoid Cystic Carcinoma

Hao Li
Xiao‐lin Nong
Yan‐ning Li
Research01 Mar 2010
International Journal of Oral Science

Volume: 2, P: 35-44
Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

Zinc is a nutritional factor implicated in autism spectrum disorders (ASDs), but evidence for a strong association and linking mechanism is largely lacking. Here, the authors report that trans-synaptic zinc mobilization rapidly rescues social interaction in two independent mouse models of ASD.

Eun-Jae Lee
Hyejin Lee
Eunjoon Kim
ResearchOpen Access18 May 2015
Nature Communications

Volume: 6, P: 1-13
Phosphodiesterase 4D polymorphisms associate with the short-term outcome in ischemic stroke

Yan-li Song
Chun-juan Wang
Gai-fen Liu
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-6
Room temperature multiferroicity in Bi_4.2K_0.8Fe₂O_9+δ

Si-Ning Dong
Yi-Ping Yao
Xiao-Guang Li
ResearchOpen Access13 Feb 2013
Scientific Reports

Volume: 3, P: 1-6
Low-intensity extracorporeal shock wave therapy for erectile dysfunction after radical prostatectomy: a review of preclinical studies

Zi-jun Zou
Jia-yu Liang
Yi-ping Lu
Reviews27 Nov 2017
International Journal of Impotence Research

Volume: 30, P: 1-7
Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway

Osteoclasts are bone resorptive cells and an attractive target to treat diseases characterized by excessive bone loss, but little is known about osteoclast inhibition. Here the authors identify Gα13 as an intracellular inhibitor of osteoclastogenesis that can prevent bone loss in mice via Akt activation and inhibition of RhoA signalling.

Mengrui Wu
Wei Chen
Yi-Ping Li
ResearchOpen Access19 Jan 2017
Nature Communications

Volume: 8, P: 1-13
Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals

COVID-19-convalescent individuals maintain a strong neutralizing antibody response to SARS-CoV-2 that has cross-reactivity to SARS-CoV and MERS-CoV. Neutralizing antibody titres depend on the severity of the disease and are positively correlated with the frequency of CXCR3⁺ T follicular helper cells and lymphocyte counts.

Jian Zhang
Qian Wu
Xiaowang Qu
Research16 Nov 2020
Nature Microbiology

Volume: 6, P: 51-58
Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways

Guohua Zhang
Zhelong Liu
Yi-Ping Li
ResearchOpen Access23 May 2017
Scientific Reports

Volume: 7, P: 1-8
Status of HBsAg seroprevalence in 15 million rural couples in China: a cross-sectional study

Long Zhang
Yuan-Yuan Wang
Xu Ma
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-7
BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Li et al. show that BCAA transaminase 2 enhances uptake and catabolism of branched-chain amino acids, thereby promoting development of pancreatic ductal adenocarcinoma harbouring KRAS mutations.

Jin-Tao Li
Miao Yin
Qun-Ying Lei
Research06 Feb 2020
Nature Cell Biology

Volume: 22, P: 167-174
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

Enhanced glycolysis in cancer cells has been associated with protection from DNA damage. Here the authors show that DNA damaging signals induce acetylation of PFKFB3 at lysine K472 and promote its cytosolic accumulation, which enhances glycolysis, resulting in protection from cisplatin-induced cell death.

Fu-Long Li
Jin-Ping Liu
Hai-Xin Yuan
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-17
Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

High-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and current evidences link E7 to HPV-associated carcinogenesis. Here the authors propose a model in which the infection of epithelial cells with high risk HPV results in a burst of reactive oxygen species, translocation of LDHA to the nucleus and activation of a gene profile that supports the growth of cervical cancer.

Yuan Liu
Ji-Zheng Guo
Qun-Ying Lei
ResearchOpen Access24 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

Yi-ping You
Liang Yan
Xian-hui He
Research02 Sept 2024
Acta Pharmacologica Sinica

Volume: 46, P: 430-447
Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly

Si-yuan Chen
Ya-ping Li
Xian-hui He
Research23 May 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2019-2036
Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

Jue Wang
Abigail McVicar
Yi-Ping Li
ResearchOpen Access21 Aug 2023
International Journal of Oral Science

Volume: 15, P: 1-11
Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway

Fei Gao
Jiao-meng Li
Li-jiang Xuan
Research07 Jan 2019
Acta Pharmacologica Sinica

Volume: 40, P: 867-878
S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway

Yi-Ping Tao
Heng-Yan Zhu
Wei-Wei Pan
ResearchOpen Access12 Oct 2023
Oncogene

Volume: 42, P: 3491-3502
The functional change of the P2X7R containing the Ala³⁴⁸ to Thr polymorphism is associated with the pathogenesis of gout

Man-Yun Li
Xuan Fang
Xiang-Pei Li
ResearchOpen Access05 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

Mengrui Wu
Guiqian Chen
Yi-Ping Li
ReviewsOpen Access26 Apr 2016
Bone Research

Volume: 4, P: 1-21
Identification of a Potent and Broad-Spectrum Hepatitis C Virus Fusion Inhibitory Peptide from the E2 Stem Domain

Xiaojing Chi
Yuqiang Niu
Wei Yang
ResearchOpen Access28 Apr 2016
Scientific Reports

Volume: 6, P: 1-14
Water use efficiency in a primary subtropical evergreen forest in Southwest China

Qing-Hai Song
Xue-Hai Fei
Yu-Hong Liu
ResearchOpen Access20 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Refining the optimal CAF cluster marker for predicting TME-dependent survival expectancy and treatment benefits in NSCLC patients

Kai Li
Rui Wang
Da-Peng Liu
ResearchOpen Access21 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans

Yabin Hu
Qian Wu
Xiaowang Qu
ResearchOpen Access22 Oct 2024
npj Vaccines

Volume: 9, P: 1-11

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