Nature Search

Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography

Antimicrobial peptide mechanism of membrane disruption have not been fully characterized at the cellular level. Here, authors use cryo-electron tomography and AFM to directly visualize the disruption of the outer and inner membranes of Escherichia coli by a de novo-designed peptide.

Eric H.-L. Chen
Chun-Hsiung Wang
Rita P.-Y. Chen
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-12
N-Cadherin promotes cardiac regeneration by potentiating pro-mitotic β-Catenin signaling in cardiomyocytes

Adult human hearts exhibit restricted regenerative ability, where cardiomyocyte loss leads to dysfunction, while neonatal hearts can regenerate, though the molecular mechanisms remain poorly understood. Here, the authors show that N-cadherin plays a crucial role in driving cardiomyocyte self-renewal by stabilizing β-catenin, representing a unique opportunity to promote cardiac regeneration and restore contractile function in the injured adult heart

Yi-Wei Tsai
Yi-Shuan Tseng
Kai-Chien Yang
ResearchOpen Access21 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Atomic layer-deposited tunnel oxide stabilizes silicon photoanodes for water oxidation

Electrochemical energy can be produced by using solar energy to oxidize water, providing an abundant source of electrons, which are needed in fuel synthesis. The operation of an efficient and stable semiconductor nanocomposite anode, made of a protective TiO₂ layer that protects a silicon substrate during photoelectrochemical water oxidation in both dark and light conditions, is now reported.

Yi Wei Chen
Jonathan D. Prange
Paul C. McIntyre
Research19 Jun 2011
Nature Materials

Volume: 10, P: 539-544
Author Correction: In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems

Shrawan Kumar Mageswaran
Amandine Guérin
Yi-Wei Chang
Amendments and CorrectionsOpen Access21 Oct 2021
Nature Communications

Volume: 12, P: 1
NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia

NME3 is a member of NDPK family. Here, Chen et. al., discover that histidine phosphorylatable NME3 is required for hypoxia-induced mitophagy via PA-dependent interaction with Drp1, which is protected from MUL1-mediated ubiquitination for mitophagy.

Chih-Wei Chen
Chi Su
Zee-Fen Chang
ResearchOpen Access13 Mar 2024
Nature Communications

Volume: 15, P: 1-20
In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems

The rhoptry is an apical secretory organelle of apicomplexan parasites that is essential for host cell invasion. Here, Mageswaran et al. provide in situ ultrastructures of rhoptries from two pathogens, revealing a conserved architecture including luminal filaments and a distinct docking mechanism.

Shrawan Kumar Mageswaran
Amandine Guérin
Yi-Wei Chang
ResearchOpen Access17 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Microbes translocation from oral cavity to nasopharyngeal carcinoma in patients

Oral microbes in non-oral locations are noted across various cancers. This study highlights the abnormal translocation of oral microbes to the nasopharynx, raising the risk of nasopharyngeal cancer by remodeling the tumor microenvironment and potentially influencing EBV infection.

Ying Liao
Yan-Xia Wu
Wei-Hua Jia
ResearchOpen Access22 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Negative birefraction of acoustic waves in a sonic crystal

Ming-Hui Lu
Chao Zhang
Nai-Ben Ming
Research26 Aug 2007
Nature Materials

Volume: 6, P: 744-748
Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

Endothelial cells (ECs) and bone marrow stromal cells (BMSCs) support hematopoiesis and hematopoietic regeneration. Whether ECs are a source of BMSCs remains unclear. Here, using lineage tracing models the authors show that ECs are not a source of BMSCs during homeostasis and regeneration.

Jia Cao
Ling Jin
Hui Xie
ResearchOpen Access20 Dec 2023
Nature Communications

Volume: 14, P: 1-15
The impact of ZTE-based MR attenuation correction compared to CT-AC in ¹⁸F-FBPA PET before boron neutron capture therapy

Yi-Wen Lo
Ko-Han Lin
Wen-sheng Huang
ResearchOpen Access17 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
A nationwide study on new onset atrial fibrillation risk factors and its association with hospital mortality in sepsis patients

Yi-wei Liu
Yi-fan Wang
Bin Du
ResearchOpen Access28 May 2024
Scientific Reports

Volume: 14, P: 1-7
Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.

Zhen-Xing Wang
Zhong-Wei Luo
Hui Xie
ResearchOpen Access18 Mar 2022
Nature Communications

Volume: 13, P: 1-20
Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography

Cryo-electron tomography reveals the ultrastructure of the rhoptry secretory apparatus in Plasmodium falciparum.

Matthew Martinez
William David Chen
Yi-Wei Chang
Research11 Jul 2022
Nature Microbiology

Volume: 7, P: 1230-1238
Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography

This paper combines cryo-electron tomography with super-resolution fluorescence microscopy for precise localization of molecular tags on a cellular or macromolecular structure, without fixation.

Yi-Wei Chang
Songye Chen
Grant J Jensen
Research11 May 2014
Nature Methods

Volume: 11, P: 737-739
Predicting the optimal concentration of remifentanil for skull pin fixation with hemodynamic and analgesia nociception index monitoring

Yi-Wei Kuo
Ying-Tzu Chen
Zhi-Fu Wu
ResearchOpen Access18 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography

Apicomplexan parasites utilize a unique actomyosin system to mediate motility and host cell invasion. Here, the authors apply cryo-ET to Cryptosporidium parvum and Toxoplasma gondii to visualize the F-actin architecture in the native cellular context.

Matthew Martinez
Shrawan Kumar Mageswaran
Yi-Wei Chang
ResearchOpen Access09 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Measuring the α-particle charge radius with muonic helium-4 ions

The 2S–2P transitions in muonic helium-4 ions are measured using laser spectroscopy and used to obtain an α-particle charge-radius value five times more precise than that from electron scattering.

Julian J. Krauth
Karsten Schuhmann
Franz Kottmann
ResearchOpen Access27 Jan 2021
Nature

Volume: 589, P: 527-531
Caribbean plate tilted and actively dragged eastwards by low-viscosity asthenospheric flow

Here, the authors follow a new approach using analytic solutions for Poiseuille-Couette channel flow to compute asthenospheric viscosities under the Caribbean. Active asthenospheric flow observed under the Caribbean contradicts the traditional view that the asthenosphere is only a passive lubricating layer for Earth’s tectonic plates.

Yi-Wei Chen
Lorenzo Colli
Hejun Zhu
ResearchOpen Access11 Mar 2021
Nature Communications

Volume: 12, P: 1-9
Macroscopic matter wave quantum tunnelling

Quantum tunnelling as a non-equilibrium process is a problem of quantum physics that has been investigated in several microscopic systems. Motivated by attosecond ionization experiments and the puzzle of tunnelling time, the authors report experimental results on the quantum tunnelling of a Bose–Einstein Condensate out of an optical dipole trap.

Khemendra Shukla
Po-Sung Chen
Yi-Wei Liu
ResearchOpen Access01 Jun 2020
Communications Physics

Volume: 3, P: 1-7
Southward propagation of Nazca subduction along the Andes

The current phase of subduction of the Nazca slab was established in the Peruvian Andes after a plate reorganization around 80 million years ago and then propagated progressively southwards.

Yi-Wei Chen
Jonny Wu
John Suppe
Research23 Jan 2019
Nature

Volume: 565, P: 441-447
Low-photon-number optical switch and AND/OR logic gates based on quantum dot-bimodal cavity coupling system

Shen Ma
Han Ye
Yu-Min Liu
ResearchOpen Access11 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations

Zhi-bin Hu
Wei-tang Liu
Yu-qiang Ding
ResearchOpen Access26 Jun 2025
Acta Pharmacologica Sinica

P: 1-14
Neuroinflammation leads to pharmacoresistance in temporal lobe epilepsy via promoting spermine degradation

Meng-qi Yan
Xiao-yun Qiu
Ceng-lin Xu
Research17 Jun 2025
Acta Pharmacologica Sinica

P: 1-16
A new view into prokaryotic cell biology from electron cryotomography

In this Review, Oikonomou and Jensen discuss how electron cryotomography has provided structural and mechanistic insights into the physiology of bacteria and archaea, from morphogenesis to subcellular compartmentalization and from metabolism to complex interspecies interactions.

Catherine M. Oikonomou
Yi-Wei Chang
Grant J. Jensen
Reviews29 Feb 2016
Nature Reviews Microbiology

Volume: 14, P: 205-220
Publisher Correction: Measuring the α-particle charge radius with muonic helium-4 ions

Julian J. Krauth
Karsten Schuhmann
Franz Kottmann
Amendments and CorrectionsOpen Access27 Feb 2021
Nature

Volume: 591, P: E18
Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

Ni et al. report that Snail1 promotes mammary tumour initiation and maintenance independently of its role in EMT. They show that Snail1 forms a complex with HDAC1 and p53 that results in p53 inactivation and degradation, permitting tumour formation.

Ting Ni
Xiao-Yan Li
Stephen J. Weiss
Research17 Oct 2016
Nature Cell Biology

Volume: 18, P: 1221-1232
Oral microbiota signature predicts the prognosis of colorectal carcinoma

Shi-Hao Zhou
Yan Du
Wei-Hua Jia
ResearchOpen Access05 May 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-11
Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy

Fazlul H Sarkar
Yi-wei Li
Reviews01 Sept 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1305-1315
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma

Jun-ying Wang
Meng-ping Chen
Jian Hou
ResearchOpen Access14 Apr 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2496-2508
Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice

Bing-Yao Zhou
Ze-Xuan Li
Yu-Qiang Ding
ResearchOpen Access20 Mar 2025
Neuropsychopharmacology

Volume: 50, P: 1224-1236
A reappraisal of the prevalence of pediatric hypertension through a nationwide database in Taiwan

Wan-Fu Hsu
Yi-Wei Kao
Kai-Sheng Hsieh
ResearchOpen Access24 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Real-time holographic camera for obtaining real 3D scene hologram

A real-time holographic camera for acquiring high-fidelity holograms of real 3D scenes based on a elastic membrane liquid camera and a focal stack network is proposed.

Zhao-Song Li
Chao Liu
Qiong-Hua Wang
ResearchOpen Access08 Feb 2025
Light: Science & Applications

Volume: 14, P: 1-11
Effectiveness of human-origin Lactobacillus plantarum PL-02 in improving muscle mass, exercise performance and anti-fatigue

Mon-Chien Lee
Yi-Ju Hsu
Chi-Chang Huang
ResearchOpen Access30 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
An Automatic Assessment System for Alzheimer’s Disease Based on Speech Using Feature Sequence Generator and Recurrent Neural Network

Yi-Wei Chien
Sheng-Yi Hong
Li-Chen Fu
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice

Yun-Hsiang Chen
Kuo-Jen Wu
Yun Wang
ResearchOpen Access07 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3

Hsiao-Yun Chen
Liang-Ting Lin
Shih-Hwa Chiou
ResearchOpen Access18 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

Chun-Yuan Chen
Shan-Shan Rao
Hui Xie
ResearchOpen Access26 Jun 2019
Bone Research

Volume: 7, P: 1-14
Indolent enhancing spinal lesions mimicking spinal metastasis in pediatric patients with malignant primary brain tumors

Hsin-Wei Wu
Shih-Chieh Lin
Feng-Chi Chang
ResearchOpen Access02 Feb 2022
Scientific Reports

Volume: 12, P: 1-10
Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression

Zhe Ruan
Hao Yin
Hui Xie
ResearchOpen Access16 Aug 2023
Bone Research

Volume: 11, P: 1-13
Liquid lens based holographic camera for real 3D scene hologram acquisition using end-to-end physical model-driven network

A holographic camera for acquiring high-fidelity holograms of real 3D scenes based on a liquid camera and an end-to-end physical model-driven network is proposed.

Di Wang
Zhao-Song Li
Qiong-Hua Wang
ResearchOpen Access29 Feb 2024
Light: Science & Applications

Volume: 13, P: 1-10
Ultrasensitive detection of Cu²⁺ with the naked eye and application in immunoassays

A novel method based on the AuNPs for fast, sensitive and selective detection of Cu²⁺ was developed and applied in immunoassays.

Chun-Hua Lu
Yi-Wei Wang
Huang-Hao Yang
ResearchOpen Access16 Mar 2012
NPG Asia Materials

Volume: 4, P: e10
Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery

Di Sun
Shi-yan Guo
Zheng-tao Wang
Research18 Sept 2019
Acta Pharmacologica Sinica

Volume: 41, P: 119-128
The pursuit of further miniaturization of screen printed micro paper-based analytical devices utilizing controlled penetration towards optimized channel patterning

Hsiu-Yang Tseng
Jose H. Lizama
Chiu-Jen Chen
ResearchOpen Access02 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Employment of a high throughput functional assay to define the critical factors that influence vaccine induced cross-variant neutralizing antibodies for SARS-CoV-2

Yue Gu
Bhuvaneshwari Shunmuganathan
Paul A. MacAry
ResearchOpen Access09 Dec 2023
Scientific Reports

Volume: 13, P: 1-14

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