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While they resemble antiferromagnets in terms of vanishing magnetization, altermagnets also have a nonrelativistic spin-splitting bandstructure arising from the combination of crystal symmetry and magnetic ordering. Here, Zhang et al demonstrate the effective manipulation of spin-splitting torque based on the control of Néel vector in altermagnets.

AI scientists powered by large language models and AI agents present both opportunities and risks in automatic scientific discovery. Here, the authors examine the vulnerabilities of AI scientists, propose a risk taxonomy based on user intent and impact domains, and develop a triadic safeguarding framework emphasizing human regulation, agent alignment, and environmental feedback understanding.

The sign of the Casimir force depends on the electric permittivities and the magnetic permeabilities of the materials involved. For a gold sphere immersed in a ferrofluid, tuneability of the Casimir force by means of a magnetic field is now shown.

The realization and control many-body quantum states in perovskites would extend their application to ultrafast quantum operation. Here, the authors generate a cooperative quantum state of excitons in a lead halide perovskite quantum dot ensemble and control the ultrafast radiation through optical microcavites.

An atomically thin high-κ gate dielectric of Bi₂SeO₅ can be formed via layer-by-layer oxidization of an underlying two-dimensional semiconductor, allowing high-performance field-effect transistors and inverters to be fabricated.

Measuring pharmacodynamics (PD) is vital for drug development but traditional PD studies are labor and resource intensive. Wu et al. introduce a kinase-modulated bioluminescent indicator for noninvasive visualization of Akt-related drug PD in living animals.

The authors solved the cryo-EM structure of Myomaker, essential for myoblast fusion, and showed that it adopts a GPCR-like fold. They pinpointed the role of the dimeric interface and lipid-binding sites for fusion, and proposed a mechanism that may be conserved between species.

The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy.

The receptor-interacting protein (RIPK1) promotes cell death and contributes to nonalcoholic steatohepatitis pathogenesis. Here the authors report that a SUMO-specific protease, SENP1, deSUMOylates RIPK1 and inhibits cell death in a mouse model of non-alcoholic fatty liver disease.

An on-chip, high-bandwidth-density non-Hermitian hybrid switching network based on the integration of III–V and silicon materials is demonstrated, paving the way for compact and ultrafast monolithic integrated silicon photonics for large-scale and high-dimensional information processing.

Prodrug photolysis enables spatiotemporal control of drug release at the desired lesions, but most of the photocleavable groups cannot be directly activated by near-infrared (NIR) light that features deep penetration and low phototoxicity. Here, the authors report an upconversion-like process via only one step of energy transfer for NIR light-triggered prodrug photolysis.

Schizophrenia is a severe psychiatric disorder and the pathogenesis remains unclear. Here, the authors show a potential role for synaptotagmin-11 in schizophrenia-related behavior through dopamine over-transmission.

NanoLuc substrates with improved solubility and bioavailability, hydrofurimazine and fluorofurimazine, strongly enhance bioluminescence signals in vivo and enable bright dual-color bioluminescent imaging with AkaLuc and AkaLumine.

Kondo physics has been observed in moiré bilayers, but the expected magnetic transitions have not been reported. Now, a metal–insulator transition with ferromagnetic order that develops at nearly the same time is reported in a moiré bilayer.

Lattice shrinkage is a dominating factor for the strain-induced change of the electronic properties in vdW layered materials. Here, the authors discover a piezoresistivity in pressurized β′-In2Se3, which originates from the intralayer atomic motions.

The Haldane model is a paradigmatic example of topological behaviour but has not previously been implemented in condensed-matter experiments. Now a moiré bilayer is shown to realize this model with the accompanying quantized transport response.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

The epitaxial synthesis of high-density, vertically aligned arrays of two-dimensional (2D) fin-oxide heterostructures is described, enabling the fabrication of 2D fin field-effect transistors with high electron mobility and desirable low-power specifications.

The ultraviolet-assisted intercalative oxidation of high-mobility two-dimensional semiconductor Bi₂O₂Se can be used to create a single-crystalline native oxide dielectric—β-Bi₂SeO₅—that can yield top-gated transistors with an equivalent oxide thickness of 0.41 nm.

Morphology, composition, and uniformity of highly entropic nanoalloys are critical to their properties and applications. Here, the authors develop a DNA origami-based metallization reaction concept for the precise synthesis of multimetallic nanopatterns.

The synthesis of optically enriched atropisomers has so far been limited to molecules containing aryl groups. Now a variant of non-aryl atropisomerism has been identified in vinyl sulfoxonium ylides, and an organocatalytic method has been developed to produce these molecules. This type of axial chirality is characterized by restricted rotation of the central C(sp²)–C(sp²) bond.

Xu et al. provide a single-cell transcriptomic atlas of 4–6 week human embryos, thereby profiling early human organogenesis.

Acheiropodia is associated with homozygous deletions in the LMBR1 gene around ZRS, an enhancer regulating SHH during limb development, but how these deletions lead to this phenotype is unknown. Here the authors use whole-genome sequencing, ChIP-seq, 4C-seq and DNA FISH to show that alterations in CTCF motifs are responsible via altered enhancer–promoter interactions.

Researchers used single-nucleus RNA and ATAC sequencing to create an atlas of skeletal muscle development. They identified the gene programs and transcription factors that control muscle fiber development and maturation.

Kim et al. demonstrate neutrophil- and macrophage-enriched subtypes in triple-negative breast cancer and how these immune profiles affect therapeutic responses to immune checkpoint blockade.

MATQ-seq is a highly sensitive single-cell RNA-seq protocol that enables the detection of true subtle biological variations among single cells as well as the capture of nonpolyadenylated RNA.

Large-size single-crystal van der Waals layered Bi₂SeO₅ has been synthesized with a high dielectric constant and high breakdown field strength for two-dimensional electronics applications.

PheCAP takes structured data and narrative notes from electronic medical records and enables patients with a particular clinical phenotype to be identified.

The three core problems of CQD laser research and the corresponding solutions for achieving high-temperature CQD lasers.