Nature Search

NAT10-mediated mRNA N⁴-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Subo Zhang
Feng Huang
Huilin Huang
ResearchOpen Access06 Nov 2024
Nature Cell Biology

Volume: 26, P: 2168-2182
Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity

Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activating this pathway rescues CREB-dependent memory in aged worms.

Shiyi Zhou
Katherine E. Novak
Coleen T. Murphy
ResearchOpen Access27 May 2025
Nature Aging

Volume: 5, P: 1232-1248
m⁶A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

Feng Huang
Yushuai Wang
Hengyou Weng
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-18
A clean transfer approach to prepare centimetre-scale black phosphorus crystalline multilayers on silicon substrates for field-effect transistors

Black phosphorus (BP) is a 2D semiconductor with potential for (opto-)electronic applications, but its large-scale integration with Si substrates is challenging. Here, the authors report a method to transfer cm-scale BP films onto SiO₂/Si substrates retaining their uniformity and electrical properties.

Yuqian Zhao
Jianfeng Mao
Jianhua Hao
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-8
Transfer learning guided discovery of efficient perovskite oxide for alkaline water oxidation

Discovering new active catalysts for water splitting is of high interest. Here the authors develop a generalizable transfer learning approach to accelerate the prediction of perovskite electrocatalysts, and report Pr_0.1Sr_0.9Co_0.5Fe_0.5O₃ and Pr_0.1Sr_0.9Co_0.5Fe_0.3Mn_0.2O₃ as active catalysts for water oxidation.

Chang Jiang
Hongyuan He
Yifei Sun
ResearchOpen Access26 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids

Coptis chinensis represents an early-diverging eudicot lineage with diverse medicinal applications. Here, the authors report its chromosome-scale genome assembly, infer a single ancient whole-genome duplication, and characterize the function of CYP719 in diversification of protoberberine-type alkaloids.

Yifei Liu
Bo Wang
Jing Nie
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Hydrogen spillover in complex oxide multifunctional sites improves acidic hydrogen evolution electrocatalysis

While renewable H₂ production offers a promising route for clean energy production, there is an urgent need to improve catalyst performances. Here, authors design a Pt-containing complex oxide that utilizes atomic-scale hydrogen spillover to promote H₂ evolution electrocatalysis in acidic media.

Jie Dai
Yinlong Zhu
Zongping Shao
ResearchOpen Access04 Mar 2022
Nature Communications

Volume: 13, P: 1-10
Direct observation of intrinsic room-temperature ferroelectricity in 2D layered CuCrP₂S₆

CuCrP₂S₆ is a potential candidate for realizing low-dimensional multiferroicity. Here, authors report direct observation of robust out-of-plane ferroelectricity in the two-dimensional van der Waals layered CuCrP₂S₆ at room temperature down to 2.6 nm and study its origin from an atomic perspective. (299 in total)

Weng Fu Io
Sin -Yi Pang
Jianhua Hao
ResearchOpen Access11 Nov 2023
Nature Communications

Volume: 14, P: 1-10
Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty

A study using single-cell RNA sequencing to map transcriptomic landscapes across Bama pig testes development reveals early onset meiosis, a unique spermatogonia subtype, and persistent myoid progenitors.

Xiaoyan Wang
Yang Wang
Jianguo Zhao
ResearchOpen Access09 Nov 2024
Communications Biology

Volume: 7, P: 1-14
FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

Aberrant activation of TGF-β signalling promotes cancer metastasis but the initial steps of this activation are unclear. Here Xieet al. show that FAF1 regulates the surface levels of TGF-β type II receptor thus influencing the persistence of the signalling and breast cancer metastasis.

Feng Xie
Ke Jin
Long Zhang
ResearchOpen Access26 Apr 2017
Nature Communications

Volume: 8, P: 1-16
Macroscale and microcircuit dissociation of focal and generalized human epilepsies

Weng et al. harness multimodal neuroimaging and computational modeling to examine whole-brain dysfunction in patients with generalized (GE) and temporal lobe epilepsy (TLE) as well as healthy controls. They find more severe microcircuit and macroscale imbalances in TLE than GE, illustrating the power of this integrated approach.

Yifei Weng
Sara Larivière
Boris C. Bernhardt
ResearchOpen Access18 May 2020
Communications Biology

Volume: 3, P: 1-11
Physiology and proteomic analysis reveals root, stem and leaf responses to potassium deficiency stress in alligator weed

Liqin Li
Chengcheng Lyu
Liming Lu
ResearchOpen Access22 Nov 2019
Scientific Reports

Volume: 9, P: 1-13
LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis

Yifei Shen
Jingwen Xu
Shisheng He
ResearchOpen Access24 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-14
FKBP5 haplotypes and PTSD modulate the resting-state brain activity in Han Chinese adults who lost their only child

Rongfeng Qi
Yifeng Luo
Guang Ming Lu
ResearchOpen Access13 Mar 2020
Translational Psychiatry

Volume: 10, P: 1-10
Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child

Rongfeng Qi
Yifeng Luo
Guang Ming Lu
ResearchOpen Access30 Jan 2020
Translational Psychiatry

Volume: 10, P: 1-12
Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

Mingxue Di
Lin Wang
Mei Zhang
ResearchOpen Access13 Jul 2017
Cell Death & Disease

Volume: 8, P: e2917

Search

NAT10-mediated mRNA N⁴-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity

m⁶A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability

A clean transfer approach to prepare centimetre-scale black phosphorus crystalline multilayers on silicon substrates for field-effect transistors

Transfer learning guided discovery of efficient perovskite oxide for alkaline water oxidation

Analysis of the Coptis chinensis genome reveals the diversification of protoberberine-type alkaloids

Hydrogen spillover in complex oxide multifunctional sites improves acidic hydrogen evolution electrocatalysis

Direct observation of intrinsic room-temperature ferroelectricity in 2D layered CuCrP₂S₆

Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis

Macroscale and microcircuit dissociation of focal and generalized human epilepsies

Physiology and proteomic analysis reveals root, stem and leaf responses to potassium deficiency stress in alligator weed

LncRNA KCNQ1OT1 sponges miR-34c-5p to promote osteosarcoma growth via ALDOA enhanced aerobic glycolysis

FKBP5 haplotypes and PTSD modulate the resting-state brain activity in Han Chinese adults who lost their only child

Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child

Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress

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