Nature Search

pNaktide reverses metabolic reprogramming and disease progression of ATP1A1-deficiency clear cell renal cell carcinoma

Yinghong Zhao
Jialing Lv
Chao Zhang
ResearchOpen Access07 Oct 2025
Cancer Gene Therapy

P: 1-15
Metabolism archetype cancer cells induce protumor TREM2⁺ macrophages via oxLDL-mediated metabolic interplay in hepatocellular carcinoma

Tumour cells can alter the function and metabolism of immune cells to reduce anti-tumour responses. Here the authors use single cell sequencing of HCC and show three tumour archetypes; metabolism, inflammation and stemness and the metabolism archetype are found in association with TREM⁺ macrophages which restrict immune cell infiltration into the tumour microenvironment.

Tianhao Chu
Guiqi Zhu
Yinghong Shi
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-25
Author Correction: Intra-islet α-cell Gs signaling promotes glucagon release

Liu Liu
Kimberley EI
Jürgen Wess
Amendments and CorrectionsOpen Access29 Jul 2024
Nature Communications

Volume: 15, P: 1
Enhanced nanoparticle delivery across vascular basement membranes of tumours using nitric oxide

Nitric oxide reversibly breaches vascular basement membrane barriers, facilitating nanoparticle penetration into the tumour interstitium through explosive eruptions.

Wei Jiang
Zixuan Guo
Yucai Wang
Research02 May 2025
Nature Biomedical Engineering

Volume: 9, P: 1486-1501
Intra-islet α-cell Gs signaling promotes glucagon release

Glucagon plays a key role in regulating blood glucose levels. Here, Liu et al. show that
activation of α-cell Gs signaling promotes the release of glucagon from pancreatic islets and ensures the synthesis of sufficient amounts of glucagon.

Liu Liu
Kimberley El
Jürgen Wess
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition

Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcus anaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.

Weiwei Cui
Meng Guo
Bo Chu
Research02 Jan 2024
Nature Cell Biology

Volume: 26, P: 124-137
A TRIM insertion in the promoter of Ms2 causes male sterility in wheat

The male-sterilems2 mutant has facilitated commercial production of wheat for over 40 years. Here, Xia et al. map Ms2and describe how a retrotransposon insertion event in the regulatory element of an orphan gene is associated with expression in anthers and development of male sterility.

Chuan Xia
Lichao Zhang
Xiuying Kong
ResearchOpen Access12 May 2017
Nature Communications

Volume: 8, P: 1-9
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

The molecular mechanisms underlying the development of thrombocytopenia in multiple myeloma (MM) remain to be explored. Here, the authors show an association of thrombocytopenia with poor prognosis in MM and identify serine as a key metabolic regulator of thrombocytopenia.

Chunmei Kuang
Meijuan Xia
Wen Zhou
ResearchOpen Access13 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Reference genome assemblies reveal the origin and evolution of allohexaploid oat

A reference-quality genome assembly of hexaploid oat variety ‘Sanfensan’ and genome assemblies of its diploid and tetraploid Avena ancestors provide insights into the evolutionary history of allohexaploid oat.

Yuanying Peng
Honghai Yan
Changzhong Ren
ResearchOpen Access18 Jul 2022
Nature Genetics

Volume: 54, P: 1248-1258
Enabling giant thermopower by heterostructure engineering of hydrated vanadium pentoxide for zinc ion thermal charging cells

The application of zinc ion thermal charging cells has been limited by their low kinetics and rapid energy decay. Here, the authors develop a promising material by heterostructure engineering of hydrated vanadium pentoxide for high-performance harvesting and conversion of low-grade heat.

Zhiwei Li
Yinghong Xu
Xiaogang Zhang
ResearchOpen Access26 Oct 2023
Nature Communications

Volume: 14, P: 1-11
Wind-driven device for cooling permafrost

This work demonstrates a wind-powered device for cooling permafrost in the Qinghai-Tibet Plateau region. Composed of a windmill, mechanical clutch, and a heat exchanger with a phase change material, pilot experiments show soil temperature reduction with superior efficiency compared to traditional thermosyphons.

Yinghong Qin
Tianyu Wang
Weixin Yuan
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-10
Zinc ion thermal charging cell for low-grade heat conversion and energy storage

Low-grade heat conversion has recently emerged and displayed great promise in sustainable electronics and energy areas. Here, the authors propose a new zinc ion thermal charging cell with hybrid behaviours for high value-added conversion from heat to electricity.

Zhiwei Li
Yinghong Xu
Xiaogang Zhang
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-10
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance

The bone tumour microenvironment plays an essential role in multiple myeloma (MM) development. Here, the authors show that bone collagen degradation provides glycine to support MM progression through glutathione and purine synthesis.

Jiliang Xia
Jingyu Zhang
Wen Zhou
ResearchOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis

Beta3-adrenergic receptor signaling regulates adipose tissue browning. Here, the authors show that barr2 regulates internalization of beta3-adrenergic receptors and that mice lacking barr2 in adipocytes are protected from diet-induced weight gain and metabolic complications.

Sai P. Pydi
Shanu Jain
Jürgen Wess
ResearchOpen Access03 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Adipocyte G_i signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity

Gs-coupled receptor signaling is well known to modulate adipocyte metabolism, but the role of Gi-coupled receptors in adipose tissue is less well understood. Here the authors show that signaling via Gi-type G proteins expressed by adipocytes is essential for maintaining proper blood glucose homeostasis.

Lei Wang
Sai P. Pydi
Jürgen Wess
ResearchOpen Access12 Jun 2020
Nature Communications

Volume: 11, P: 1-17
Adipocyte G_q signaling is a regulator of glucose and lipid homeostasis in mice

Obesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mice, suggesting that agents able to stimulate this pathway may prove useful as antidiabetic drugs.

Takefumi Kimura
Sai P. Pydi
Jürgen Wess
ResearchOpen Access29 Mar 2022
Nature Communications

Volume: 13, P: 1-17
Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells

In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β₂-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.

Jaroslawna Meister
Derek B. J. Bone
Jürgen Wess
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Many tumors evade immunosurveillance by down-modulating expression of antigen-processing machinery and MHC molecules. Yang et al. report triple-negative tumor cell expression of the lncRNA LINK-A enhances degradation of antigen peptide-loading complex molecules and intrinsic tumor suppressors, which contribute to tumor persistence.

Qingsong Hu
Youqiong Ye
Liuqing Yang
Research03 Jun 2019
Nature Immunology

Volume: 20, P: 835-851
Soil seed burial and competition with surrounding plants determine the emergence and development of seedling of an endangered species Horsfieldia hainanensis Merr. in China

Xiongsheng Liu
Yinghui He
Yi Jiang
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study

Zhongni Liu
Hong Li
Yong Zhou
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-7
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis.

Ryan Kolb
Liem Phan
Weizhou Zhang
ResearchOpen Access06 Oct 2016
Nature Communications

Volume: 7, P: 1-12
Methyltransferase like 3 inhibition limits intrahepatic cholangiocarcinoma metabolic reprogramming and potentiates the efficacy of chemotherapy

Jun Gao
Yuan Fang
Yinghong Shi
Research07 Jul 2023
Oncogene

Volume: 42, P: 2507-2520
Different carotenoid conformations have distinct functions in light-harvesting regulation in plants

Carotenoids can dissipate excess energy captured by photosynthetic light-harvesting complexes to prevent photodamage. Here, via spectroscopic and in silico approaches, Liguori et al. resolve different carotenoid dark states and propose conformational changes that permit them to act as either energy donors or quenchers.

Nicoletta Liguori
Pengqi Xu
Roberta Croce
ResearchOpen Access08 Dec 2017
Nature Communications

Volume: 8, P: 1-9
TCP1 promotes the progression of malignant tumours by stabilizing c-Myc through the AKT/GSK-3β and ERK signalling pathways

TCP1 promotes tumour progression by disrupting the degradation of the oncogene c-Myc in the context of hepatocellular carcinoma and pancreatic ductal adenocarcinoma.

Hekun Liu
Linying Chen
Yuanzhong Chen
ResearchOpen Access04 Apr 2025
Communications Biology

Volume: 8, P: 1-13
I prostanoid receptor activation attenuates pressure overload-induced cardiac hypertrophy by enhancing glucose oxidation

Qian Liu
Guizhu Liu
Ying Yu
ResearchOpen Access06 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-4
Limited ability of increased sequencing depth in detecting cases missed by noninvasive prenatal testing: a comparative analysis of 3 clinical cases

Yinghong Lu
Na Zuo
Yunrong Qin
ResearchOpen Access27 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma

Xifei Jiang
Wenjia Deng
Yinghong Shi
ResearchOpen Access17 Jan 2023
Cell Discovery

Volume: 9, P: 1-15
The synergic impacts of salt mixture and frost damage on rock decay: implications for the deterioration of rock-hewn heritages

Yinghong Wang
Hui Zhang
ResearchOpen Access26 Sept 2023
Heritage Science

Volume: 11, P: 1-16
Single-cell low-pass whole genome sequencing accurately detects circulating tumor cells for liquid biopsy-based multi-cancer diagnosis

Xiaohan Shen
Jiao Dai
Qihui Shi
ResearchOpen Access06 Feb 2024
npj Precision Oncology

Volume: 8, P: 1-12
Real-time monitoring of newly acidified organelles during autophagy enabled by reaction-based BODIPY dyes

Hanzhuang Liu et al. present new BODIPY dyes that undergo a reversible pH-dependent switch upon acidification from the colorless leuco-form to red fluorescent BODIPY. They use these probes to directly image organelle acidification associated with autophagy in real time.

Hanzhuang Liu
Wenting Song
Zhen Shen
ResearchOpen Access28 Nov 2019
Communications Biology

Volume: 2, P: 1-11
Molecular spectrum of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese colorectal cancer patients: analysis of 1,110 cases

Jing Zhang
Jianming Zheng
Tonghua Liu
ResearchOpen Access22 Dec 2015
Scientific Reports

Volume: 5, P: 1-8
FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

Louise V O'Keefe
Yinghong Liu
Robert I Richards
Research20 Jun 2005
Oncogene

Volume: 24, P: 6590-6596
Diagnostic utility of TP53 and cytokeratin 7 immunohistochemistry in idiopathic inflammatory bowel disease-associated neoplasia

Hao Xie
Shu-Yuan Xiao
Xiuli Liu
Research26 Jul 2013
Modern Pathology

Volume: 27, P: 303-313
Methylenetetrahydrofolate reductase gene polymorphisms and cerebral palsy in Chinese infants

Xiuyong Cheng
Tongchuan Li
Qinghe Xing
Research21 Oct 2010
Journal of Human Genetics

Volume: 56, P: 17-21
Glucocorticoid activates STAT3 and NF-κB synergistically with inflammatory cytokines to enhance the anti-inflammatory factor TSG6 expression in mesenchymal stem/stromal cells

Peiqing Huang
Rongrong Sun
Yufang Shi
ResearchOpen Access18 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-9
CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils

Zheying Mao
Jiahui Zhang
Xu Zhang
ResearchOpen Access06 Jul 2020
Oncogenesis

Volume: 9, P: 1-14
Targeting SRSF1 improves cancer immunotherapy by dually acting on CD8⁺T and tumor cells

Gui-Qi Zhu
Zheng Tang
Jia Fan
ResearchOpen Access22 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-16
Sucrose and ABA regulate starch biosynthesis in maize through a novel transcription factor, ZmEREB156

Huanhuan Huang
Sidi Xie
Yubi Huang
ResearchOpen Access10 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Identification and functional analysis of the ICK gene family in maize

Qianlin Xiao
Chunxia Zhang
Yubi Huang
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Noninvasive prenatal testing for β-thalassemia by targeted nanopore sequencing combined with relative haplotype dosage (RHDO): a feasibility study

Fuman Jiang
Weiqiang Liu
Xiaofang Sun
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s

Meirong Zang
Jiaojiao Guo
Wen Zhou
ResearchOpen Access05 Mar 2020
Oncogenesis

Volume: 9, P: 1-13
Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Meng-Xi Liu
Lei Jin
Yue Xiong
Research16 Jan 2018
Oncogene

Volume: 37, P: 1637-1653
Epigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer

Hanyang Hu
Maoguo Shu
Xiaohua Chen
ResearchOpen Access31 Jan 2017
British Journal of Cancer

Volume: 116, P: 658-668
CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Gui-Qi Zhu
Zheng Tang
Ying-Hong Shi
ResearchOpen Access06 Mar 2023
Cell Discovery

Volume: 9, P: 1-22
Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection

Wei-Ren Liu
Meng-Xin Tian
Ying-Hong Shi
ResearchOpen Access07 May 2020
British Journal of Cancer

Volume: 123, P: 92-100
SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models

Xi-fei Jiang
Yang Dai
Jing Ai
Research14 Sept 2017
Acta Pharmacologica Sinica

Volume: 39, P: 243-250
Upconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation

Xiaobo B Han
Hongxia X Li
Liming M Yang
ResearchOpen Access08 Jun 2017
Cell Death & Disease

Volume: 8, P: e2864
Chemerin has a protective role in hepatocellular carcinoma by inhibiting the expression of IL-6 and GM-CSF and MDSC accumulation

Y Lin
X Yang
R He
Research06 Feb 2017
Oncogene

Volume: 36, P: 3599-3608

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