Nature Search

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

Here, the authors employed 19 F NMR and Gaussian accelerated MD simulations to determine the conformational landscape of the adenosine-A2A receptor and mini-Gαsβγ complex, enabling determination of an intermediate structure of the complex with cryoEM.

Maxine Bi
Xudong Wang
Libin Ye
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Cryo-EM reveals an extrahelical allosteric binding site at the M₅ mAChR

The M₅ muscarinic acetylcholine receptor represents a promising therapeutic target for neurological disorders. Here, the authors reveal a 2.1 Å cryo-EM structure of the M₅ bound to a selective positive allosteric modulator site that enables structure-based drug design.

Wessel A. C. Burger
Jesse I. Mobbs
David M. Thal
ResearchOpen Access31 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Architecture and activation of single-pass transmembrane receptor guanylyl cyclase

Here the authors show the structures of single-pass transmembrane receptor guanylyl cyclase in both apo and hormone-bound states, advancing our understanding of cross-membrane signaling by single-pass transmembrane receptors.

Shian Liu
Alexander M. Payne
Xin-Yun Huang
Research14 Nov 2024
Nature Structural & Molecular Biology

Volume: 32, P: 469-478
Structural basis of agonist specificity of α_1A-adrenergic receptor

α1-adrenergic receptors (α1- AR) play critical roles in the cardiovascular and nervous systems. Here, the authors report molecular insights into the mechanisms underlying the discrimination between α1A-AR and α1B-AR by the agonist A61603.

Minfei Su
Jinan Wang
Xin-Yun Huang
ResearchOpen Access10 Aug 2023
Nature Communications

Volume: 14, P: 1-12
Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies

Su et al. report cryo-EM structures of β₁-adrenergic receptor, Gs and ligands of different efficacies. These complexes have similar overall architecture, but with local conformational differences and different stabilities.

Minfei Su
Navid Paknejad
Xin-Yun Huang
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-13
Positive allosteric mechanisms of adenosine A₁ receptor-mediated analgesia

MIPS521, a positive allosteric modulator of the adenosine A₁ receptor, has analgesic properties in a rat model of neuropathic pain through a mechanism by which MIPS521 stabilizes the complex between adenosine, receptor and G protein.

Christopher J. Draper-Joyce
Rebecca Bhola
Arthur Christopoulos
Research08 Sept 2021
Nature

Volume: 597, P: 571-576
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

Gaussian accelerated molecular dynamics (GaMD) simulations and biochemical experiments in E.Coli provide mechanistic insight into how Presenilin-1 familial Alzheimer’s disease mutations affect structural dynamics and enzyme-substrate interactions of γ-secretase and APP

Hung N. Do
Sujan Devkota
Yinglong Miao
ResearchOpen Access14 Feb 2023
Communications Biology

Volume: 6, P: 1-14
Distinct binding conformations of epinephrine with α- and β-adrenergic receptors

Jian-Shu Lou
Minfei Su
Xin-Yun Huang
ResearchOpen Access02 Sept 2024
Experimental & Molecular Medicine

Volume: 56, P: 1952-1966
Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor

Yinglong Miao
Apurba Bhattarai
Lauren T. May
ResearchOpen Access15 Nov 2018
Scientific Reports

Volume: 8, P: 1-13

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