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Showing 1–4 of 4 results
Advanced filters: Author: Yingxiao Gao Clear advanced filters

  • Tryptophan plays important biological roles in aromatic cages, such as methyllysine recognition, but the development of site-selective crosslinking to tryptophan is challenging. Now sulfonium can be used as a methyllysine mimic that binds to reader proteins and crosslinks tryptophan inside a pocket through single-electron transfer. This strategy enables the identification of methyllysine readers from the proteome.

    • Feng Feng
    • Yingxiao Gao
    • Mingxuan Wu
    Research
    Nature Chemistry
    Volume: 16, P: 1267-1277

  • Two protein circuit systems, split-protease-cleavable orthogonal coiled-coil logic (SPOC logic) and circuits of hacked orthogonal modular proteases (CHOMP), have been developed to permit rapid and logic function-based control of mammalian cellular signaling.

    • Yiqian Wu
    • Yingxiao Wang
    News & Views
    Nature Chemical Biology
    Volume: 15, P: 96-97

  • There remains a critical need for precise control of CRISPR-based technologies. Here, the authors develop a focused ultrasound (FUS)-controllable CRISPR toolbox, allowing the noninvasive and spatiotemporal control of genomic/epigenomic reprogramming for cancer treatment combined with CAR-T therapy.

    • Yiqian Wu
    • Ziliang Huang
    • Yingxiao Wang
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The drug AT-527 targets the SARS-CoV-2 replication machinery. Here the authors use Cryo-EM to show how AT-527 inhibits SARS-CoV-2 polymerase by acting as an immediate RNA chain terminator and stably binding in a NiRAN active-site pocket; impeding an essential nucleotide-transfer activity.

    • Ashleigh Shannon
    • Véronique Fattorini
    • Bruno Canard
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9