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A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma

The mechanisms involved in the formation of the premetastatic niche in hepatocellular carcinoma (HCC) are not completely elucidated. Here, the authors show that matrix stiffness in HCC induces cancer-exosome release which increases glucose availability in the lung premetastatic niche favouring metastasis formation and growing.

Yingying Zhao
Hongmei Yu
Jiefeng Cui
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-26
The “Vessel through Strait” Sign is a Signature Radiological Sign for the Diagnosis of Left Hepatic Artery Variation

Guanghua Rong
Zhijun Wang
Yongwu Li
ResearchOpen Access04 Apr 2016
Scientific Reports

Volume: 6, P: 1-5
Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway

Ruimei Ren
Shan Zhang
Yinying Dong
ResearchOpen Access20 Jul 2025
Cell Death & Disease

Volume: 16, P: 1-12
Necrolytic migratory erythema is an important visual cutaneous clue of glucagonoma

Wei Li
Xue Yang
Zheng Wang
ResearchOpen Access31 May 2022
Scientific Reports

Volume: 12, P: 1-7
Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence

The efficacy of tumour starvation therapy is limited by lack of persistent tumour suppression, tumour metastasis and recurrence. Here, the authors report biocompatible gold nanorods and thermal-sensitive hydrogel to promote narrowing of blood vessels and show this to reduce tumour growth and metastasis.

Kun Zhang
Yan Fang
Huixiong Xu
ResearchOpen Access26 Nov 2019
Nature Communications

Volume: 10, P: 1-17
Self-assembled nanostructures in ionic liquids facilitate charge storage at electrified interfaces

Understanding molecular interactions between ionic liquids and interfaces is crucial for electrochemical device applications. Self-assembled amphiphilic nanostructures in surface-active ionic liquids are shown to exhibit enhanced charge storage at electrified surfaces.

Xianwen Mao
Paul Brown
T. Alan Hatton
Research12 Aug 2019
Nature Materials

Volume: 18, P: 1350-1357
In vivo capture and label-free detection of early metastatic cells

Tumour metastasis is a significant source of mortality, often because it is detected at an advanced stage. In this study, in an effort to identify metastasis at an early stage, Azarin et. al. capture and image metastasizing cells in mice in vivousing a biomaterial scaffold.

Samira M. Azarin
Ji Yi
Lonnie D Shea
Research08 Sept 2015
Nature Communications

Volume: 6, P: 1-9
Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma

Shuheng Bai
YinYing Wu
Juan Ren
ResearchOpen Access12 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

Chao Hu
Hualan Yang
Jican Dai
ResearchOpen Access23 Jun 2016
Scientific Reports

Volume: 6, P: 1-12

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A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma

The “Vessel through Strait” Sign is a Signature Radiological Sign for the Diagnosis of Left Hepatic Artery Variation

Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway

Necrolytic migratory erythema is an important visual cutaneous clue of glucagonoma

Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence

Self-assembled nanostructures in ionic liquids facilitate charge storage at electrified interfaces

In vivo capture and label-free detection of early metastatic cells

Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma

The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

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