Using Pd homogeneous catalysts for direct C–H arylation is an attractive approach for synthesizing natural products and organic functional materials, but limitations in terms of cost and catalyst recovery could be alleviated by alternative heterogeneous catalytic processes. Here, the authors report a Pd single-atom/cluster cocatalyst supported on non-enzymatic browning glucose for the direct coupling of inert C-H bonds with aryl iodides that breaks the activity-stability trade-off via a PdII/PdIV catalytic cycle, and demonstrate C(sp3)-H or C(sp2)-H bond activation tunability by tailoring the structure of the catalyst support.
- Xiaojie He
- Wunengerile Zhang
- Yong-Sheng Bao
