Park et al. assess the therapeutic efficacy of mitochondrial transplantation with or without O-GlcNAc modification of isolated mitochondria. O-GlcNAcylation can prevent glycation while improving both the functional properties of mitochondria and the neuroprotective efficacy of transplantation in a mouse model of focal cerebral ischemia.
- Ji Hyun Park
- Masayoshi Tanaka
- Kazuhide Hayakawa