Nature Search

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
A mutation of mitochondrial DNA in Japanese families with Leber's hereditary optic neuropathy

Keiko Fujiki
Yoshihiro Hotta
Akira Nakajima
Research08 Jun 2005
Japanese journal of human genetics

Volume: 36, P: 143-147
Reply to “Normal brain development in importin-α5 deficient-mice”

Noriko Yasuhara
Yoshihiro Yoneda
Correspondence01 Dec 2007
Nature Cell Biology

Volume: 9, P: 1339
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis

Yongke Zhang
Naoya Fujita
Takashi Tsuruo
Research18 Feb 1998
Oncogene

Volume: 16, P: 693-703
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Infrared laser–mediated gene induction in targeted single cells in vivo

An infrared laser is used to activate gene expression from a heat shock promoter in single cells in Caenorhabditis elegans, and is shown to be more effective and less detrimental to cells than a visible laser used for this purpose.

Yasuhiro Kamei
Motoshi Suzuki
Shunsuke Yuba
Research14 Dec 2008
Nature Methods

Volume: 6, P: 79-81
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

Setsuko Sahara
Mamoru Aoto
Yoshihide Tsujimoto
Research09 Sept 1999
Nature

Volume: 401, P: 168-173
Triggering neural differentiation of ES cells by subtype switching of importin-α

Noriko Yasuhara
Noriko Shibazaki
Yoshihiro Yoneda
Research10 Dec 2006
Nature Cell Biology

Volume: 9, P: 72-79
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Discrimination of the oral microbiota associated with high hydrogen sulfide and methyl mercaptan production

Toru Takeshita
Nao Suzuki
Yoshihisa Yamashita
ResearchOpen Access09 Jan 2012
Scientific Reports

Volume: 2, P: 1-8
Prevalence of unilateral hyperaldosteronism in primary aldosteronism: impact of a novel chemiluminescent immunoassay for measuring plasma aldosterone in Japan

Hiroki Kobayashi
Yoshihiro Nakamura
Michio Otsuki
Research29 Jul 2024
Hypertension Research

Volume: 47, P: 3035-3044
A hyperaldosteronism subtypes predictive model using ensemble learning

Shigehiro Karashima
Masaki Kawakami
Shozo Miyauchi
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
A toxic monomeric conformer of the polyglutamine protein

Yoshitaka Nagai
Takashi Inui
Tatsushi Toda
Research18 Mar 2007
Nature Structural & Molecular Biology

Volume: 14, P: 332-340
PGC7/Stella protects against DNA demethylation in early embryogenesis

Toshinobu Nakamura
Yoshikazu Arai
Toru Nakano
Research03 Dec 2006
Nature Cell Biology

Volume: 9, P: 64-71
Degradation of stable thermosetting epoxy resins mediated by bases in amide solvents

The degradation of various thermosetting epoxy resins prepared from bisphenol A diglycidyl ether as a typical epoxy agent and various curing agents, such as diamino arenes, dithiols, and acid anhydrides proceeded smoothly with sodium tert-butoxide in 1,3-dimethyl-2-imidazolidinone (DMI) solvent at 150 °C to form bisphenol A in high yields. Amide solvents effectively promoted depolymerization and allowed insoluble cross-linked thermosetting epoxy resins to undergo the reaction.

Yasunori Minami
Tomoo Tsuyuki
Masaru Yoshida
Research18 Nov 2024
Polymer Journal

Volume: 57, P: 149-162
Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism

Naoki Fujiwara
Tatsuya Haze
Michio Otsuki
Research15 Oct 2024
Hypertension Research

Volume: 48, P: 540-552
Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice

Koki Sakurai
Makiko Morita
Yoichi Miyamoto
ResearchOpen Access08 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-10
Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling

Kohji Yamada
Yoichi Miyamoto
Masahiro Oka
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network

Tetsuji Moriyama
Shu Tanaka
Masahiro Oka
ResearchOpen Access05 Oct 2016
Scientific Reports

Volume: 6, P: 1-11
A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene–environment interactions

Hirotaka Nomiya
Koki Sakurai
Masami Yamada
ResearchOpen Access09 Feb 2024
Scientific Reports

Volume: 14, P: 1-18
Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism

Regarding Japanese primary aldosteronism, the low, intermediate, and high renin change groups (classified based on the response of renin to mineralocorticoid antagonist treatment) had CVD incidence of 2.1%, 0.5%, and 3.7%, respectively, during the 5-year study period.

Motoko Nomura
Isao Kurihara
Chiba Yoshiro
Research28 Jun 2022
Hypertension Research

Volume: 45, P: 1476-1485
SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication

The SARS-CoV-2 ORF6, an antagonist of interferon-mediated antiviral signaling, directly binds to STAT1 and prevents its nuclear localization.

Yoichi Miyamoto
Yumi Itoh
Masahiro Oka
ResearchOpen Access19 May 2022
Communications Biology

Volume: 5, P: 1-15
Transportin-2 plays a critical role in nucleocytoplasmic shuttling of oestrogen receptor-α

Tetsuji Moriyama
Yoshihiro Yoneda
Masami Yamada
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-17
Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism

Ryo Nakamaru
Koichi Yamamoto
Daisuke Yabe
ResearchOpen Access25 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD

Takumi Kawaguchi
Katsutoshi Tokushige
Takuji Torimura
ResearchOpen Access11 Jul 2018
Scientific Reports

Volume: 8, P: 1-13
Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan

Yuichi Fujii
Yoshiyu Takeda
Takahisa Kawaguchi
Research28 Aug 2019
Journal of Human Hypertension

Volume: 34, P: 34-42
Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism

Shintaro Sakaguchi
Ryuji Okamoto
Mitsuhide Naruse
Research24 Sept 2022
Journal of Human Hypertension

Volume: 37, P: 757-766
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

Tomoyasu Sugiyama
Shigeomi Shimizu
Yoshihide Tsujimoto
Research16 Jul 2002
Oncogene

Volume: 21, P: 4944-4956

Search

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A mutation of mitochondrial DNA in Japanese families with Leber's hereditary optic neuropathy

Reply to “Normal brain development in importin-α5 deficient-mice”

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Production of interleukin-11 in bone-derived endothelial cells and its role in the formation of osteolytic bone metastasis

Blood DNA virome associates with autoimmune diseases and COVID-19

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Infrared laser–mediated gene induction in targeted single cells in vivo

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

Triggering neural differentiation of ES cells by subtype switching of importin-α

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Discrimination of the oral microbiota associated with high hydrogen sulfide and methyl mercaptan production

Prevalence of unilateral hyperaldosteronism in primary aldosteronism: impact of a novel chemiluminescent immunoassay for measuring plasma aldosterone in Japan

A hyperaldosteronism subtypes predictive model using ensemble learning

A toxic monomeric conformer of the polyglutamine protein

PGC7/Stella protects against DNA demethylation in early embryogenesis

Degradation of stable thermosetting epoxy resins mediated by bases in amide solvents

Differences in target organ damage between captopril challenge test-defined definitive-positive and borderline-range groups among patients with primary aldosteronism

Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice

Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling

Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network

A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene–environment interactions

Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism

SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication

Transportin-2 plays a critical role in nucleocytoplasmic shuttling of oestrogen receptor-α

Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism

A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD

Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan

Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

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