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Showing 1–50 of 54 results

Advanced filters: Author: Yoshimasa Takahashi Clear advanced filters

MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

Lipids are complex molecules crucial for life. The authors developed MS-DIAL 5, a tool that enhances in-depth structure elucidations and the spatial mapping of lipidome. Using advanced techniques, they uncovered new insights into the biosynthetic pathway of eye-specific phosphatidylcholines.

Hiroaki Takeda
Yuki Matsuzawa
Hiroshi Tsugawa
ResearchOpen Access28 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors show that sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice.

Yuhsuke Ohmi
Wataru Ise
Koichi Furukawa
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-12
Evasion of antiviral bacterial immunity by phage tRNAs

Retrons are bacterial genetic elements that, in combination with toxic effector proteins, can serve as antiphage defense systems. Here, the authors show that some phages can evade retrons and other defense systems by expressing specific tRNAs.

Aa Haeruman Azam
Kohei Kondo
Kotaro Kiga
ResearchOpen Access11 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Shape of the first mitotic spindles impacts multinucleation in human embryos

Defects in cell division occur often in early embryos, though the mechanisms underlying these errors and their correction remain unclear. Here they develop a method for imaging zygotic chromosomes during human zygotic cleavage and find that the spindle shape influences formation of micronuclei.

Yuki Ono
Hiromitsu Shirasawa
Yukihiro Terada
ResearchOpen Access25 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Isolation and characterization of novel bacteriophages targeting Stenotrophomonas maltophilia

Wakana Yamashita
Yuta Sato
Kotaro Kiga
ResearchOpen Access13 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Prevalence of common aneuploidy in twin pregnancies

Akiko Konishi
Osamu Samura
Haruhiko Sago
ResearchOpen Access01 Jan 2022
Journal of Human Genetics

Volume: 67, P: 261-265
Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

In this study, the authors isolated SARS-CoV-2 receptor binding site monoclonal antibodies resistant to Omicron mutations. An amino acid in the receptor binding domain, tyrosine-489, is a virus-vulnerable site and a common footprint of broadly neutralizing antibodies.

Saya Moriyama
Yuki Anraku
Yoshimasa Takahashi
ResearchOpen Access14 Jul 2023
Nature Communications

Volume: 14, P: 1-17
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

Antibody cross-reactivity can help to prevent escape mutations from enabling viral escape, but underlying mechanisms are unclear. Here the authors identify influenza hemagglutinin epitopes that are exposed during viral replication and which result in the generation of a class of protective cross-reactive antibodies.

Yu Adachi
Keisuke Tonouchi
Yoshimasa Takahashi
ResearchOpen Access28 Aug 2019
Nature Communications

Volume: 10, P: 1-13
Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain

Takano et al. show that heterologous booster by SARS-CoV-2 recombinant spike protein vaccine recalls a more sustained and broader anti-spike receptor-binding domain antibody response compared to homologous booster by mRNA vaccine.

Tomohiro Takano
Takashi Sato
Yoshimasa Takahashi
ResearchOpen Access15 Mar 2023
Nature Communications

Volume: 14, P: 1-13
Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

The hepatitis B vaccine is recognised as the most effective approach in reducing hepatitis-B-related morbidity; vaccine-escape mutations are however capable of infecting vaccinated individuals. In this work, authors aim to establish a hepatitis B vaccine candidate, which they assess in rhesus macaques in terms of efficacy and safety.

Ayaka Washizaki
Asako Murayama
Takanobu Kato
ResearchOpen Access05 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Novobiocin primarily targets ParE in Neisseria gonorrhoeae

Yoshimasa Ishizaki
Chigusa Hayashi
Masayuki Igarashi
Research16 Dec 2024
The Journal of Antibiotics

Volume: 78, P: 159-165
Synergistic activation of bat SARS-like coronaviruses spike protein by elastase and TMPRSS2

Yuichiro Yamamoto
Tetsuya Inoue
Kohji Noguchi
ResearchOpen Access21 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen

This study demonstrates that multimerization of single-domain antibodies (VHHs) targeting MPXV M1R significantly enhances neutralizing activity. the approach offers a modular platform for engineering next-generation antivirals against orthopoxviruses.

Daisuke Akazawa
Masayuki Shimojima
Koichi Watashi
ResearchOpen Access18 Jul 2025
Communications Biology

Volume: 8, P: 1-11
Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells

The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.

Kosuke Miyauchi
Yu Adachi
Masato Kubo
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

EAF2 has been previously known as a transcriptional elongation factor and a proapoptotic gene lost in prostate cancer. Here the authors show that EAF2 is required for apoptosis of germinal centre B cells, and that EAF2-deficient mice develop excessive antibody responses and autoimmunity.

Yingqian Li
Yoshimasa Takahashi
Ji-Yang Wang
ResearchOpen Access03 Mar 2016
Nature Communications

Volume: 7, P: 1-13
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2

Kentaro Uemura
Michihito Sasaki
Akihiko Sato
ResearchOpen Access08 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Functional D-box sequences reset the circadian clock and drive mRNA rhythms

Hikari Yoshitane, Yoshimasa Asano et al. investigate role of the D-box genomic element in the circadian clockwork and identify 1490 D-box-containing regions that are bound by DBP and E4BP4 in the mouse liver. Using mice lacking liver expression of E4bp4, they demonstrate the importance of the D-box element for mediating environmental input response and resetting the circadian clock.

Hikari Yoshitane
Yoshimasa Asano
Yoshitaka Fukada
ResearchOpen Access08 Aug 2019
Communications Biology

Volume: 2, P: 1-10
Synthesis and Characterization of Block Copolymers: Poly(ethylene oxide-b-methacrylonitrile) and Poly(ethylene oxide-b-acrylonitrile)

Toshimitsu Suzuki
Yoshimasa Murakami
Yoshinobu Takegami
Research01 Jun 1982
Polymer Journal

Volume: 14, P: 431-439
Molecular Weight Distribution and Intrinsic Viscosity of Sonicated and Successively Fractionated Double-Stranded Deoxyribonucleic Acid and Polyribonucleotides

Masato Tanigawa
Nobuaki Mukaiyama
Kiwamu Yamaoka
Research01 Mar 1994
Polymer Journal

Volume: 26, P: 291-302
Predictive factors of prognosis after radiation and steroid pulse therapy in thyroid eye disease

Makoto Ito
Yasuhiro Takahashi
Kojiro Suzuki
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-7
A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome

Hironori Bando
Genzo Iguchi
Yutaka Takahashi
ResearchOpen Access20 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1

Midbrain dopaminergic neurons generated from stem cells show promise for the treatment of Parkinson’s disease. Here, the authors use the cell surface marker, LRTM1, to enrich the midbrain dopaminergic progenitors and show improved motor function/cell survival when grafted into rat/monkey brains, respectively.

Bumpei Samata
Daisuke Doi
Jun Takahashi
ResearchOpen Access14 Oct 2016
Nature Communications

Volume: 7, P: 1-11
Regulated selection of germinal-center cells into the memory B cell compartment

T cells provide help to B cells in germinal centers. Kurosaki and colleagues show that B cells of lower affinity receive weaker T cell help. This scenario results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells.

Ryo Shinnakasu
Takeshi Inoue
Tomohiro Kurosaki
Research09 May 2016
Nature Immunology

Volume: 17, P: 861-869
Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice

Fumikiyo Nagawa
Natsuko Kishishita
Hitoshi Sakano
Research24 Dec 2006
Nature Immunology

Volume: 8, P: 206-213
Protective neutralizing influenza antibody response in the absence of T follicular helper cells

T follicular helper (T_FH) cells are important for the formation of germinal centers and antibody responses. Kubo and colleagues show that T_H1 cells can induce a protective antibody response in the complete absence of T_FH cells and germinal centers.

Kosuke Miyauchi
Akiko Sugimoto-Ishige
Masato Kubo
Research31 Oct 2016
Nature Immunology

Volume: 17, P: 1447-1458
Cycloimidamicins, Novel natural lead compounds for translation inhibition in Pseudomonas aeruginosa

Yoshimasa Ishizaki
Maya Umekita
Masayuki Igarashi
Research27 Sept 2023
The Journal of Antibiotics

Volume: 76, P: 691-698
Prolonged effects of adenoviral vector priming on T-cell cytokine production in heterologous adenoviral vector/mRNA COVID-19 vaccination regimens

Masanori Isogawa
Taishi Onodera
Tomomi Tsuru
ResearchOpen Access28 May 2025
Scientific Reports

Volume: 15, P: 1-11
Microfluidic nanobubbles produced using a micromixer for ultrasound imaging and gene delivery

Taiki Yamaguchi
Yoko Endo-Takahashi
Yoichi Negishi
ResearchOpen Access28 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
Phage engineering to overcome bacterial Tmn immunity in Dhillonvirus

Two distinct phage engineering strategies—mutating phage genes targeted by bacterial anti-phage systems and arming phages with genes that counteract these systems—have enabled the circumvention of bacterial anti-phage defenses.

Wakana Yamashita
Kotaro Chihara
Kotaro Kiga
ResearchOpen Access22 Feb 2025
Communications Biology

Volume: 8, P: 1-9
Synthetic phage-based approach for sensitive and specific detection of Escherichia coli O157

Efficient phage synthesis yields O157 antigen-specific phages with the detection tag at optimal sites, enabling specific detection of diverse E. coli O157 clinical isolates and suggesting broad applications in bacterial detection and phage therapy.

Azumi Tamura
Aa Haeruman Azam
Kotaro Kiga
ResearchOpen Access06 May 2024
Communications Biology

Volume: 7, P: 1-13
Instability of the 16S rRNA methyltransferase-encoding npmA gene: why have bacterial cells possessing npmA not spread despite their high and broad resistance to aminoglycosides?

Yoshimasa Ishizaki
Yuko Shibuya
Masayuki Igarashi
Research08 Jun 2018
The Journal of Antibiotics

Volume: 71, P: 798-807
Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants

A SARS-CoV-2 antibody, NT-108, exhibits potent therapeutic effects in vivo. Cryo-EM structure of the spike complexed with single-chain Fv of NT108 reveals its neutralizing mechanism, providing insight into antibody therapeutic design.

Yuki Anraku
Shunsuke Kita
Katsumi Maenaka
ResearchOpen Access22 Mar 2025
Communications Biology

Volume: 8, P: 1-12
Molecular convergence of neutralizing antibodies in human revealed by repeated rabies vaccination

Mizuki Fujisawa
Taishi Onodera
Yoshimasa Takahashi
ResearchOpen Access23 Feb 2025
npj Vaccines

Volume: 10, P: 1-14
Calboxyvinyl polymer adjuvant enhances respiratory IgA responses through mucosal and systemic administration

Eita Sasaki
Hideki Asanuma
Yoshimasa Takahashi
ResearchOpen Access11 Feb 2025
npj Vaccines

Volume: 10, P: 1-19
Synthesis and Characterization of Block Copolymers of Poly(ethylene oxide) and Poly(methyl methacrylate)

Toshimitsu Suzuki
Yoshimasa Murakami
Yoshinobu Takegami
Research01 Mar 1980
Polymer Journal

Volume: 12, P: 183-192
Studies on Interaction between Inorganic Material and Polymer by Inverse Gas Chromatography

Yoshimasa Murakami
Research01 May 1994
Polymer Journal

Volume: 26, P: 607-612
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Publisher Correction: A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

Yamato Wada
Arnone Nithichanon
Yoshimasa Takahashi
Amendments and CorrectionsOpen Access08 Oct 2019
Scientific Reports

Volume: 9, P: 1
Depolarization time and extracellular glutamate levels aggravate ultraearly brain injury after subarachnoid hemorrhage

Satoshi Murai
Tomohito Hishikawa
Isao Date
ResearchOpen Access17 Jun 2022
Scientific Reports

Volume: 12, P: 1-11
Multimodal single-cell analyses of peripheral blood mononuclear cells of COVID-19 patients in Japan

Yukie Kashima
Taketoshi Mizutani
Yutaka Suzuki
ResearchOpen Access02 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4⁺ T cells

Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interaction between fatty acid metabolism and the acquired immune response.

Toshio Kanno
Takahiro Nakajima
Yusuke Endo
ResearchOpen Access29 Jun 2021
Communications Biology

Volume: 4, P: 1-14
Hop bitter acids containing a β-carbonyl moiety prevent inflammation-induced cognitive decline via the vagus nerve and noradrenergic system

Yasuhisa Ano
Rena Ohya
Hiroyuki Nakayama
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

Wipawee Saenwongsa
Arnone Nithichanon
Ganjana Lertmemongkolchai
ResearchOpen Access24 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Diagnosis of NTM active infection in lymphadenopathy patients with anti-interferon-gamma auto-antibody using inhibitory ELISA vs. indirect ELISA

Arnone Nithichanon
Ploenchan Chetchotisakd
Ganjana Lertmemongkolchai
ResearchOpen Access02 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

Yamato Wada
Arnone Nithichanon
Yoshimasa Takahashi
ResearchOpen Access28 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2

Masayuki Igarashi
Ryuichi Sawa
Chiaki Kato
Research03 Feb 2021
The Journal of Antibiotics

Volume: 74, P: 291-299
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13

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