Nature Search

Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Experimental evidence for the existence of a second partially-ordered phase of ice VI

Water ice exhibits several hydrogen-ordered and disordered phases and it’s unclear if a disordered phase can transform into only one ordered phase. Here, the authors identify a partially hydrogen-ordered phase at high pressure, ice XIX, as the second hydrogen-ordered phase of ice VI beside ice XV.

Ryo Yamane
Kazuki Komatsu
Hiroyuki Kagi
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-6
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Here, the authors identify six risk SNPs for systemic sclerosis by performing GWAS on Japanese patients and meta-analyzing Japanese and European GWAS datasets. Downstream analyses indicate that B cells contribute to pathogenesis.

Yuki Ishikawa
Nao Tanaka
Chikashi Terao
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Author Correction: Experimental evidence for the existence of a second partially-ordered phase of ice VI

Ryo Yamane
Kazuki Komatsu
Hiroyuki Kagi
Amendments and CorrectionsOpen Access15 Mar 2021
Nature Communications

Volume: 12, P: 1
Effects of Polyelectrolytes on the Complexation between Pyrenesulfonate and Anthraquinonesulfonate Ions

Yoshiya Kawabata
Tomoyuki Itaya
Akira Imamura
Research01 May 1995
Polymer Journal

Volume: 27, P: 542-546
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Multi-ancestry genome-wide association analyses identify 124 risk loci for rheumatoid arthritis, of which 34 are novel. A polygenic risk score based on multi-ancestry data showed comparable performance between populations of European and East Asian ancestries.

Kazuyoshi Ishigaki
Saori Sakaue
Soumya Raychaudhuri
Research04 Nov 2022
Nature Genetics

Volume: 54, P: 1640-1651
Factors in glucocorticoid regimens associated with treatment response and relapses of IgG4-related disease: a multicentre study

Mirei Shirakashi
Hajime Yoshifuji
Tsuneyo Mimori
ResearchOpen Access06 Jul 2018
Scientific Reports

Volume: 8, P: 1-8
Effects of Acceptor Structure on Charge-Transfer Complexation in Aqueous Polyelectrolyte Solution

Yoshiya Kawabata
Tomoyuki Itaya
Akira Imamura
Research01 Mar 1997
Polymer Journal

Volume: 29, P: 211-217
In vivo reprogramming drives Kras-induced cancer development

Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development.

Hirofumi Shibata
Shingo Komura
Yasuhiro Yamada
ResearchOpen Access25 May 2018
Nature Communications

Volume: 9, P: 1-16
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis

Calcitonin gene-related peptide (CGRP) regulates inflammation through receptor activity-modifying protein 1 (RAMP1), a subunit of CGRP receptor. This study reveals that RAMP1 signaling in immune cells enhances lipopolysaccharide-induced lymphangiogenesis in the diaphragm, which contributes to improving lymphatic drainage from peritoneal fluid.

Seri Tsuru
Yoshiya Ito
Masataka Majima
Research07 Jan 2020
Laboratory Investigation

Volume: 100, P: 738-750
VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues

Kazuki Sekiguchi
Yoshiya Ito
Masataka Majima
ResearchOpen Access07 May 2019
Scientific Reports

Volume: 9, P: 1-14
Intestinal Microcirculatory Dysfunction During the Development of Experimental Necrotizing Enterocolitis

Yoshiya Ito
Sarah M Doelle
Bohuslav Dvorak
Research01 Feb 2007
Pediatric Research

Volume: 61, P: 180-184
Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese

Hajime Nawata
Senji Shirasawa
Takehiko Sasazuki
Research01 Nov 2004
Journal of Human Genetics

Volume: 49, P: 629-634
Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage

Eri Manabe
Satoyasu Ito
Takeshi Tsujino
ResearchOpen Access16 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Exploring the role of empathy in prolonged grief reactions to bereavement

Takuya Yoshiike
Francesco Benedetti
Kenichi Kuriyama
ResearchOpen Access10 May 2023
Scientific Reports

Volume: 13, P: 1-11
Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis

Erina Nakahara
Keiko Shimojima Yamamoto
Hitoshi Kanno
ResearchOpen Access02 Mar 2023
Human Genome Variation

Volume: 10, P: 1-6
C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer

Hiroaki Ono
Tomotaka Kato
Minoru Tanabe
ResearchOpen Access12 May 2021
Scientific Reports

Volume: 11, P: 1-14
BLT₁ signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils

Ken Kojo
Yoshiya Ito
Masataka Majima
ResearchOpen Access11 Jul 2016
Scientific Reports

Volume: 6, P: 1-15
Correction: Prenatal metal concentrations and physical abnormalities in the Japan environment and children’s study

Yuichi Nakamura
Sumitaka Kobayashi
Takahiko Katoh
Amendments and Corrections08 Mar 2024
Pediatric Research

Volume: 95, P: 1659-1661
Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children’s Study

Yuichi Nakamura
Sumitaka Kobayashi
Takahiko Katoh
Research19 Oct 2023
Pediatric Research

Volume: 95, P: 1875-1882
Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children’s Study

Kazutoshi Cho
Sumitaka Kobayashi
Takahiko Katoh
Research04 Jun 2021
Pediatric Research

Volume: 92, P: 291-298
The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy

Yoshio Matsui
Hideki Amano
Masataka Majima
Research02 Feb 2015
Laboratory Investigation

Volume: 95, P: 456-468

Search

Blood DNA virome associates with autoimmune diseases and COVID-19

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Experimental evidence for the existence of a second partially-ordered phase of ice VI

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Author Correction: Experimental evidence for the existence of a second partially-ordered phase of ice VI

Effects of Polyelectrolytes on the Complexation between Pyrenesulfonate and Anthraquinonesulfonate Ions

Mapping the human genetic architecture of COVID-19

A second update on mapping the human genetic architecture of COVID-19

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Factors in glucocorticoid regimens associated with treatment response and relapses of IgG4-related disease: a multicentre study

Effects of Acceptor Structure on Charge-Transfer Complexation in Aqueous Polyelectrolyte Solution

In vivo reprogramming drives Kras-induced cancer development

Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis

VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues

Intestinal Microcirculatory Dysfunction During the Development of Experimental Necrotizing Enterocolitis

Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese

Reduced lifespan of erythrocytes in Dahl/Salt sensitive rats is the cause of the renal proximal tubule damage

Exploring the role of empathy in prolonged grief reactions to bereavement

Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis

C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer

BLT₁ signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils

Correction: Prenatal metal concentrations and physical abnormalities in the Japan environment and children’s study

Prenatal metal concentrations and physical abnormalities in the Japan Environment and Children’s Study

Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children’s Study

The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy

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