Chiral amides are common and effective structural motifs found in many pharmaceuticals and biologically active molecules but existing synthetic methods are predominantly employed for the synthesis of α-amides and β-amides. Here, the authors present a general procedure for the copper-catalyzed enantioselective synthesis of γ-chiral amides, employing a reductive relay hydroaminocarbonylation strategy with trisubstituted allylic benzoates and hydroxylamine electrophiles.
- Yang Yuan
- Youcan Zhang
- Xiao-Feng Wu
