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Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice

The biological mechanisms regulating blood-brain barrier integrity remain unclear. Here, the authors identify microglial NLRP3-gasdermin D signaling as a driver of blood-brain barrier disruption during peripheral inflammation in mice, mediated by CXCL-dependent neutrophil recruitment.

Sung-Hyun Yoon
Chae youn Kim
Je-Wook Yu
ResearchOpen Access15 Jan 2025
Nature Communications

Volume: 16, P: 1-21
Biotransformation by beta glucosidase enhances anti inflammatory metabolites in licorice using untargeted metabolomics

Seong-Min Hong
Dae-Eung Kim
Sun Yeou Kim
ResearchOpen Access05 Aug 2025
npj Science of Food

Volume: 9, P: 1-15
Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice

Yun Hye Kim
Ju Hee Lee
Hoon-Ki Sung
ResearchOpen Access21 Feb 2019
Scientific Reports

Volume: 9, P: 1-10

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