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Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation

Youn Jung Choi
Stephanie Kim
Jae U. Jung
Amendments and Corrections07 Mar 2019
Nature Immunology

Volume: 20, P: 664
Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

Here, Kim et al. characterize SARS-CoV-2 infection in juvenile, young, and old aged ferrets to provide a further understanding of differences in COVID-19 severity in humans at different ages. Aged ferrets have higher viral loads, shed virus longer, and mimic the transcriptomic profile of severely infected patients.

Young-Il Kim
Kwang-Min Yu
Young Ki Choi
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation

Mast cells are activated and proliferate during allergic reactions which can involve mast cell specific proteins. Here the authors show that mast cell-expressed membrane protein1 (MCEMP1) is an adaptor for KIT to promote SCF mediated mast cell proliferation and lack of MCEMP1 reduces inflammation in mouse asthma models.

Youn Jung Choi
Ji-Seung Yoo
Jae U. Jung
ResearchOpen Access11 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

An age-dependent immunocompetent ferret model for severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) infection and pathogenesis recapitulates the clinical manifestations of human infections, including severe thrombocytopenia, reduced white blood cell counts and high fever with 93% mortality rate.

Su-Jin Park
Young-Il Kim
Young Ki Choi
Research10 Dec 2018
Nature Microbiology

Volume: 4, P: 438-446
SERPINB1-mediated checkpoint of inflammatory caspase activation

Serpins are a large family of serine protease inhibitors. Jae Jung and colleagues show that SERPINB1 serves an endogenous regulatory role for pro-inflammatory caspases by preventing CARD–CARD polymerization and, hence, inflammasome activation.

Youn Jung Choi
Stephanie Kim
Jae U. Jung
Research28 Jan 2019
Nature Immunology

Volume: 20, P: 276-287
Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase

Soluble fumarate reductases are essential for eukaryotic cell survival under anaerobic conditions but their mechanism is not fully understood. Here, the authors present structural and enzymatic analyses of yeast fumarate reductase Osm1, elucidating the molecular basis of maintaining redox balance during anaerobiosis.

Sunghwan Kim
Chang Min Kim
Hyun Ho Park
ResearchOpen Access19 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

The non-structural protein NSs of the severe fever with thrombocytopenia syndrome virus interacts with ABIN2 and promotes formation and signalling of the TPL2–ABIN2–p105 kinase complex to induce expression of the immune-suppressive cytokine IL-10 and enhance viral pathogenesis.

Younho Choi
Su-Jin Park
Jae U. Jung
Research07 Jan 2019
Nature Microbiology

Volume: 4, P: 429-437
Asian Zika virus strains target CD14⁺ blood monocytes and induce M2-skewed immunosuppression during pregnancy

Both African and epidemic strains of Zika virus are shown to target CD14⁺ monocytes, which are more susceptible in pregnant women, but African strains are associated with inflammatory responses, and epidemic strains with immunotolerance.

Suan-Sin Foo
Weiqiang Chen
Jae U. Jung
Research21 Aug 2017
Nature Microbiology

Volume: 2, P: 1558-1570
Autophagy during viral infection — a double-edged sword

Autophagy is crucial for innate and adaptive antiviral immunity; in turn, viruses evade and subvert autophagy to support their replication and pathogenesis. In this Review, Choi, Bowman and Jung discuss the molecular mechanisms that govern autophagy during host–virus interactions.

Younho Choi
James W. Bowman
Jae U. Jung
Reviews19 Mar 2018
Nature Reviews Microbiology

Volume: 16, P: 341-354
Deep-learning-based blood pressure estimation using multi channel photoplethysmogram and finger pressure with attention mechanism

Jehyun Kyung
Joon-Young Yang
Younho Kim
ResearchOpen Access08 Jun 2023
Scientific Reports

Volume: 13, P: 1-12

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