Nature Search

Drug-related retinal detachment pharmacovigilance signals in the real world: evidence from the FDA Adverse Event Reporting System

Xiao-Dong Chen
Kun-Hong Xiao
Qian Chen
Research10 Oct 2025
Eye

P: 1-10
The digitally accountable public representation database: online communication by U.S. officials

Yuehong Cassandra Tai
Nitheesha Nakka
Bruce A. Desmarais
ResearchOpen Access25 Sept 2025
Scientific Data

Volume: 12, P: 1-8
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Author Correction: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Xiangling Xiao
Jie Shi
Jinfang Zhang
Amendments and CorrectionsOpen Access20 Jun 2025
Nature Communications

Volume: 16, P: 1
Mechanical stretch induces hair regeneration through the alternative activation of macrophages

Mechanical stimulation is known to affect cell proliferation, differentiation, and regeneration. Here, the authors demonstrate that stretching mouse skin recruits macrophages and polarizes them into M2 cells that facilitate hair regeneration through the release of growth factors, including HGF and IGF-1

Szu-Ying Chu
Chih-Hung Chou
Oscar K. Lee
ResearchOpen Access03 Apr 2019
Nature Communications

Volume: 10, P: 1-11
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Research20 Dec 2022
Nature Genetics

Volume: 55, P: 89-99
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Most genetic studies have been done on European cohorts, which affects the efficacy of polygenic risk scores in non-European populations. Here, the authors demonstrate that a colorectal cancer PRS including Asian and European ancestries has improved performance over the European-centric PRS across racial and ethnic groups.

Minta Thomas
Yu-Ru Su
Li Hsu
ResearchOpen Access02 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Perceived urban environment elements associated with momentary and long-term well-being: An experience sampling method approach

Yu-Ru Chen
Atsushi Nakagomi
Katsunori Kondo
ResearchOpen Access05 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Ubiquitination and deubiquitination processes regulate the stability of PD-1, affecting T cell biology. Here the authors identify the ubiquitin-specific protease 5 (USP5) as a deubiquitinase for PD-1 and show that USP5 inhibition in combination with a MEK inhibitor or anti-CTLA-4 could promote anti-tumor immune responses in preclinical models.

Xiangling Xiao
Jie Shi
Jinfang Zhang
ResearchOpen Access19 May 2023
Nature Communications

Volume: 14, P: 1-19
Probing Hydrophilic Interface of Solid/Liquid-Water by Nanoultrasonics

Pierre-Adrien Mante
Chien-Cheng Chen
Chi-Kuang Sun
ResearchOpen Access01 Sept 2014
Scientific Reports

Volume: 4, P: 1-6
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila

Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.

Liang Li
Zhan Ding
Yong-Zhen Xu
ResearchOpen Access05 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Discovery of common and rare genetic risk variants for colorectal cancer

Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

Jeroen R. Huyghe
Stephanie A. Bien
Ulrike Peters
Research03 Dec 2018
Nature Genetics

Volume: 51, P: 76-87
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

This study shows that inactivation of Pml in the mouse prostate turns indolent Pten-null tumors into lethal metastatic disease. The authors identify an aberrant SREBP prometastatic lipogenic program and show that a high-fat diet induces lipid accumulation in prostate tumors and is sufficient to drive metastasis.

Ming Chen
Jiangwen Zhang
Pier Paolo Pandolfi
Research15 Jan 2018
Nature Genetics

Volume: 50, P: 206-218
Inflammation-triggered Gli1⁺ stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology

Xin-Yue Cai
Chen-Xi Zheng
Yan Jin
Research27 Feb 2025
Cellular & Molecular Immunology

Volume: 22, P: 371-389
In vivo RNA editing of point mutations via RNA-guided adenosine deaminases

RNA-guided adenosine deaminases edit point mutations in in vivo mouse models for Duchenne muscular dystrophy and ornithine transcarbamylase deficiency.

Dhruva Katrekar
Genghao Chen
Prashant Mali
Research08 Feb 2019
Nature Methods

Volume: 16, P: 239-242
The functions and regulation of the PTEN tumour suppressor: new modes and prospects

The tumour suppressor PTEN regulates various cellular processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. Recent studies into the regulation of PTEN levels and activity provide new insights into its anti-oncogenic functions and offer novel opportunities for cancer treatment.

Yu-Ru Lee
Ming Chen
Pier Paolo Pandolfi
Reviews01 Jun 2018
Nature Reviews Molecular Cell Biology

Volume: 19, P: 547-562
Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Amendments and Corrections13 Feb 2023
Nature Genetics

Volume: 55, P: 519-520
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

Yu Tian
Yi Lin
Jenny Chang-Claude
ResearchOpen Access01 Apr 2024
British Journal of Cancer

Volume: 130, P: 1687-1696
Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Niki Dimou
Andre E. Kim
Ulrike Peters
ResearchOpen Access26 Jun 2023
British Journal of Cancer

Volume: 129, P: 511-520
Development of monocyte Toll-like receptor 2 and Toll-like receptor 4 in preterm newborns during the first few months of life

Chung-Min Shen
Shih-Chang Lin
Yu Ru Kou
Research15 Feb 2013
Pediatric Research

Volume: 73, P: 685-691
The association between street connectivity and depression among older Japanese adults: the JAGES longitudinal study

Yu-Ru Chen
Masamichi Hanazato
Katsunori Kondo
ResearchOpen Access08 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Yi-Fan Chen
I-Hsuan Lin
Yun Yen
ResearchOpen Access13 Sept 2019
Scientific Reports

Volume: 9, P: 1-12
Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses

Szu-Chi Yang
Huan-Chun Lin
Chi-Kuang Sun
ResearchOpen Access09 Dec 2015
Scientific Reports

Volume: 5, P: 1-10

Search

Drug-related retinal detachment pharmacovigilance signals in the real world: evidence from the FDA Adverse Event Reporting System

The digitally accountable public representation database: online communication by U.S. officials

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Author Correction: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Mechanical stretch induces hair regeneration through the alternative activation of macrophages

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Perceived urban environment elements associated with momentary and long-term well-being: An experience sampling method approach

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Probing Hydrophilic Interface of Solid/Liquid-Water by Nanoultrasonics

Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila

Discovery of common and rare genetic risk variants for colorectal cancer

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

Inflammation-triggered Gli1⁺ stem cells engage with extracellular vesicles to prime aberrant neutrophils to exacerbate periodontal immunopathology

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

Development of monocyte Toll-like receptor 2 and Toll-like receptor 4 in preterm newborns during the first few months of life

The association between street connectivity and depression among older Japanese adults: the JAGES longitudinal study

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses

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