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Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp³)–H bonds with dihaloarenes using palladium catalysis

The synthesis of benzocyclobutenes is reported through Pd(II)-catalysed γ,δ-methylene C(sp³)–H bond activation and [2 + 2] annulation between aliphatic carboxylic acids and dihaloarenes, using bidentate carboxyl-pyridone ligands. Regiocontrol is achieved in benzocyclobutene formation through the differentiation of reactivity between the aryl iodide and bromide sites.

Liang Hu
Jie-Lun Yan
Jin-Quan Yu
Research16 Sept 2025
Nature Synthesis

P: 1-9
Safety and effectiveness of catheter ablation of atrial fibrillation in patients with mitral valve replacement mechanical versus bioprosthetic valves

Xiao-Ying Liu
De-Yong Long
Chang-Sheng Ma
ResearchOpen Access01 Oct 2025
Scientific Reports

Volume: 15, P: 1-8
A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

Yi-Chang Zhao
Yu-kun Zhang
Miao Yan
ResearchOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
Benefit of standard versus low-dose tirofiban for percutaneous coronary intervention in very elderly patients with high-risk acute coronary syndrome

Yun-ling Lin
Liang-long Chen
Wei-wei Li
Research05 May 2009
Acta Pharmacologica Sinica

Volume: 30, P: 553-558
On the mechanisms of the recurvature of super typhoon Megi

Shiqiu Peng
Yu-Kun Qian
Duanling Liu
ResearchOpen Access25 Mar 2014
Scientific Reports

Volume: 4, P: 1-9
Intraspecific N and P stoichiometry of Phragmites australis: geographic patterns and variation among climatic regions

Yu-Kun Hu
Ya-Lin Zhang
Ming Dong
ResearchOpen Access24 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Reconfigurable symmetry-broken laser in a symmetric microcavity

The directional lasing emission in whispering gallery microcavities typically resorts to breaking the structure symmetry. Here the authors demonstrate a reconfigurable symmetry-broken microlaser in a symmetric ultrahigh-Q whispering gallery microcavity, in which a chirality of lasing fields is empowered spontaneously by nonlinear effects.

Qi-Tao Cao
Ruishan Liu
Yun-Feng Xiao
ResearchOpen Access28 Feb 2020
Nature Communications

Volume: 11, P: 1-7
Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

Wen-Xin Yu
Yu-Kun Li
Zhen-Yu She
ResearchOpen Access13 Dec 2022
Cell Death Discovery

Volume: 8, P: 1-14
Two-stage deep neural network for diagnosing fungal keratitis via in vivo confocal microscopy images

Chun-Peng Li
Weiwei Dai
Yiqiang Chen
ResearchOpen Access08 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer

Miao-Zhen Qiu
Yuxian Bai
Hui-Yan Luo
ResearchOpen Access16 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-10
Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry

Isocitrate dehydrogenase (IDH) mutations can be identified by gas chromatography mass spectrometry (GC/MS). The sensitivity and specificity are 100% in gliomas for the accumulation of 2-hydroxyglutarate (2-HG), whereas the ratio of 2-HG/glutamic acid also serves as a reliable index. The modified mini-column GC/MS method could shorten the procedure to 40 min for rapid diagnosis.

Hao Xu
Yu-Kun Xia
Ying Mao
Research20 Dec 2018
Laboratory Investigation

Volume: 99, P: 588-598
The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

Xiao-min Ran
Hui Xiao
Zhen-zi Tang
ResearchOpen Access09 Nov 2023
Scientific Reports

Volume: 13, P: 1-13
Prevalence, outcomes and associated factors of SARS-CoV-2 infection in psoriasis patients of Southwest China: a cross-sectional survey

Yang Zou
Jing Xu
Ping Wang
ResearchOpen Access15 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Prevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention

Zheng-Kai Xue
Xin-Ya Dai
Kang-Yin Chen
ResearchOpen Access27 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Correction: Corrigendum: On the mechanisms of the recurvature of super typhoon Megi

Shiqiu Peng
Yu-Kun Qian
Duanling Liu
Amendments and Corrections15 Jul 2014
Scientific Reports

Volume: 4, P: 1
Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery

Si Gao
Xue-ping Liu
Xu-dong Jiang
Reviews29 Aug 2023
Acta Pharmacologica Sinica

Volume: 45, P: 23-35
China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna

Gravitational wave astronomy has opened the door to test general relativity and the effect of gravity in the Universe. The authors present the capabilities of an overlap between space gravitational wave detectors LISA and Taiji to constrain the Hubble constant to 0.5%, in 10 years, and what can be learned from the satellite pilot Taiji-1 launched in 2019.

Yue-Liang Wu
Zi-Ren Luo
Zi-Ming Zou
ReviewsOpen Access24 Feb 2021
Communications Physics

Volume: 4, P: 1-7

Search

Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp³)–H bonds with dihaloarenes using palladium catalysis

Safety and effectiveness of catheter ablation of atrial fibrillation in patients with mitral valve replacement mechanical versus bioprosthetic valves

A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

Benefit of standard versus low-dose tirofiban for percutaneous coronary intervention in very elderly patients with high-risk acute coronary syndrome

On the mechanisms of the recurvature of super typhoon Megi

Intraspecific N and P stoichiometry of Phragmites australis: geographic patterns and variation among climatic regions

Reconfigurable symmetry-broken laser in a symmetric microcavity

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development

Two-stage deep neural network for diagnosing fungal keratitis via in vivo confocal microscopy images

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer

Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry

The effect of cuproptosis-relevant genes on the immune infiltration and metabolism of gynecological oncology by multiply analysis and experiments validation

Prevalence, outcomes and associated factors of SARS-CoV-2 infection in psoriasis patients of Southwest China: a cross-sectional survey

Prevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention

Correction: Corrigendum: On the mechanisms of the recurvature of super typhoon Megi

Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery

China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna

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