Wei et al. show that the chromatin regulator MRG15 interacts with the nuclear receptor LRH-1 and is rhythmically recruited to lipid- and cholesterol-biosynthetic genes. In a nutrient-rich state, MRG15 alters histone acetylation status to activate gene transcription and lipid synthesis, whereas in a nutrient-scarce state, MRG15 genomic recruitment and lipid synthesis are reduced.
- Yuda Wei
- Cheng Tian
- Qiurong Ding
